Trans Fatty Acids

UNSATURATED FATTY ACIDS that contain at least one double bond in the trans configuration, which results in a greater bond angle than the cis configuration. This results in a more extended fatty acid chain similar to SATURATED FATTY ACIDS, with closer packing and reduced fluidity. HYDROGENATION of unsaturated fatty acids increases the trans content.

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Networked: 637 relevant articles (7 outcomes, 100 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mozaffarian, Dariush: 20 articles (01/2022 - 04/2004)
2.	King, Irena B: 12 articles (01/2016 - 02/2002)
3.	Lemaitre, Rozenn N: 10 articles (01/2022 - 02/2002)
4.	Siscovick, David S: 10 articles (01/2022 - 02/2002)
5.	Willett, Walter C: 9 articles (12/2017 - 04/2004)
6.	Dyerberg, Jørn: 8 articles (01/2018 - 01/2004)
7.	Huybrechts, Inge: 7 articles (04/2021 - 01/2015)
8.	Overvad, Kim: 7 articles (01/2020 - 05/2006)
9.	Ishida, Tatsuro: 7 articles (11/2019 - 01/2015)
10.	Toh, Ryuji: 7 articles (11/2019 - 01/2015)

Related Diseases

1.	Cardiovascular Diseases (Cardiovascular Disease) 01/01/2020 - "Human studies have established a positive association between the intake of industrial trans fatty acids and the development of cardiovascular diseases, leading several countries to enact laws that restrict the presence of industrial trans fatty acids in food products. " 05/01/2013 - "Observational studies do not show higher risks of cardiovascular disease with higher intakes of ruminant trans fatty acids. " 07/01/2011 - "Effect of trans fatty acid isomers from ruminant sources on risk factors of cardiovascular disease: study design and rationale." 01/31/2011 - "Intake of industrially produced trans fatty acids (TFAs) is, according to observational studies, associated with an increased risk of cardiovascular disease, but the causal mechanisms have not been fully elucidated. " 12/01/2023 - "Industry-produced and ruminant-derived trans-fatty acids and subclinical myocardial injury in adults without known cardiovascular disease."
2.	Atherosclerosis 04/01/2015 - "Artificial trans fatty acids promote atherosclerosis by blocking macrophage clearance of cell debris. " 12/01/2005 - "The present studies suggest that trans fatty acids may play a role in damaging and death of vascular endothelial cells in atherosclerosis." 01/01/2017 - "Some factors related to diet, such as trans fatty acids (TFA), are known to be involved in the progression of atherosclerosis in humans. " 07/01/2012 - "Through largely epidemiological evidence, trans fatty acid (TFA) intake has been associated with a variety of cardiovascular complications including atherosclerosis. " 12/01/2009 - "Trans-fatty acids in the diet stimulate atherosclerosis."
3.	Inflammation (Inflammations) 01/01/2016 - "Further in vivo studies are needed to improve understanding of the precise influence of trans fatty acids on production of pro-inflammatory markers under acute inflammation conditions." 10/01/2011 - "Consumption of industrially produced trans fatty acids (IP-TFA) has been positively associated with systemic markers of low-grade inflammation and endothelial dysfunction in cross-sectional studies, but results from intervention studies are inconclusive. " 01/01/2023 - "Plasma Trans Fatty Acids Concentrations Are Inversely Related to Bone Mineral Density and This Appears to Be Independent of Inflammation." 01/01/2022 - "Trans fatty acids (TFA) in food can cause liver inflammation. " 01/01/2021 - "trans-Fatty Acids as an Enhancer of Inflammation and Cell Death: Molecular Basis for Their Pathological Actions."
4.	Type 2 Diabetes Mellitus (MODY) 01/01/2017 - "The aim of this study was to examine the relations between intakes of total, saturated, mono-unsaturated, poly-unsaturated and trans fatty acids (SFA, MUFA, PUFA and TFA), and their dietary sources (dairy, meat and plant) with markers of type 2 diabetes risk. " 06/01/2015 - "Circulating and dietary trans fatty acids and incident type 2 diabetes in older adults: the Cardiovascular Health Study." 07/01/2011 - "Intake of industrially produced trans-fatty acids (TFA) has been linked to increased risk of type 2 diabetes mellitus in observational studies. " 01/01/2023 - "The deleterious effects of trans fatty acids (TFAs) on cardiovascular health are well established; however, their impact on type 2 diabetes remains poorly understood. " 01/01/2023 - "Different Types of Industry-Produced and Ruminant Trans Fatty Acid Intake and Risk of Type 2 Diabetes: Findings From the NutriNet-Santé Prospective Cohort."
5.	Overweight 12/01/2017 - "Increased fibre and reduced trans fatty acid intake are primary predictors of metabolic improvement in overweight polycystic ovary syndrome-Substudy of randomized trial between diet, exercise and diet plus exercise for weight control." 01/01/2019 - "Association between trans fatty acid intake and overweight including obesity in 4 to 5-year-old children from the INMA study." 01/31/2011 - "Effect of trans fatty acid intake on abdominal and liver fat deposition and blood lipids: a randomized trial in overweight postmenopausal women." 07/01/2011 - "Effect of trans-fatty acid intake on insulin sensitivity and intramuscular lipids--a randomized trial in overweight postmenopausal women." 06/29/2018 - "In both fields the goals include halting the increase in overweight and obesity and reducing NCD diet-related risk factors including reducing saturated fatty acids (SFAs) and trans fatty acids (TFAs) intake. "

Related Drugs and Biologics

1.	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)
2.	Lipids
3.	Cholesterol
4.	Lipoproteins (Lipoprotein)
5.	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)
6.	Fatty Acids (Saturated Fatty Acids)
7.	Omega-3 Fatty Acids (Omega 3 Fatty Acids)
8.	Phospholipids (Phosphatides)
9.	Linoleic Acid (Linoleate)
10.	Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1.	Therapeutics
2.	Paleolithic Diet
3.	Carbohydrate-Restricted Diet (Low Carbohydrate Diet)
4.	Caloric Restriction
5.	Fat-Restricted Diet (Diet, Fat Restricted)