|1.||Deftos, Leonard J: 29 articles (01/2014 - 04/2002)|
|2.||Falzon, Miriam: 24 articles (10/2015 - 02/2002)|
|3.||Burton, Douglas W: 20 articles (10/2012 - 04/2002)|
|4.||Esbrit, Pedro: 18 articles (07/2015 - 06/2002)|
|5.||Rosol, Thomas J: 17 articles (01/2015 - 01/2002)|
|6.||Hastings, Randolph H: 16 articles (01/2015 - 06/2002)|
|7.||Goltzman, David: 14 articles (11/2015 - 05/2002)|
|8.||Stewart, Andrew F: 13 articles (09/2011 - 05/2002)|
|9.||Esbrit, P: 13 articles (04/2008 - 01/2000)|
|10.||Onuma, Etsuro: 12 articles (05/2011 - 10/2003)|
|1.||Hypercalcemia (Milk Alkali Syndrome)
09/01/2005 - "ALL relapsed in the bone marrow 3 months after achieving complete remission, and hypercalcemia and elevation of serum PTHrP were also observed. "
11/01/1992 - "Clinically, selected PTHRP assays can be very helpful in diagnosing PTHRP-mediated hypercalcemia, but are not yet sufficiently sensitive to accurately measure normal concentrations of the protein."
09/01/1997 - "On the other hand, the frequency of patients with abnormally high plasma levels of PTHrP was significantly greater (2/9 for normocalcemia vs 5/6 for hypercalcemia, chi 2 = 5.20, p = 0.02) in patients with hypercalcemia than in normocalcemic patients. "
04/01/1994 - "Our data show that effective treatment of malignancy-associated hypercalcemia is not associated with a consistent change in serum levels of PTHrP. "
09/01/2004 - "Thus, humanized anti-PTHrP may be useful for the treatment of the humoral hypercalcemia of malignancy in humans."
09/15/1999 - "Tumors of the clear cell type expressed PTHrP to a significantly greater extent than tumors of the granular cell type. "
10/01/1993 - "Irrespective of its precise normal role however, PTHRP provides a potential therapeutic target in MAH and, with improved methods of detection, may also be useful as a tumor marker."
02/15/2006 - "Improved survival was observed for the 79% of tumors which stained positively for PTHrP [estimated univariate hazard ratio, 0.43; 95% confidence interval (95% CI), 0.30-0.62; P < 0.001]. "
02/15/2006 - "Parathyroid hormone-related protein localization in breast cancers predict improved prognosis."
11/01/1994 - "Five of seven tumors investigated by immunohistochemical staining for parathyroid hormone-related protein showed positive results. "
|3.||Neoplasm Metastasis (Metastasis)
11/01/2015 - "Additionally, PTHrP, MMP-1, and CTGF are candidate genes related to HCC bone metastasis."
01/01/2015 - "The patients with both positive TGF-β and PTHrP expression were significantly associated with the high risk of metastases. "
01/01/2015 - "Nevertheless, those with higher PTHrP expression tended to show a higher rate of bone metastasis (67.6 % vs. 45.8 %, P = 0.019). "
10/01/2014 - "The number of metastatic lesions and the percentage of animals with metastasis were markedly lower in mice injected with Pthrp-ablated A375, and 45% of these animals survived a 7-week period compared with 15% of mice injected with nonablated WT-A375. "
01/01/2014 - "Patient's parathyroid hormone-related protein levels were normal and a bone scintigram revealed no evidence of skeletal metastasis. "
|4.||Breast Neoplasms (Breast Cancer)
01/01/2015 - "The objective of the current study was to evaluate the association of PTHrP and TGF-β level with the clinicopathological features of the breast cancer patients. "
01/01/2012 - "These studies implicate PTHrP in the development and growth of primary breast tumors and underscore the need for further research."
02/01/2011 - "In this study, we tested the hypothesis that Hh inhibition in bone metastatic breast cancer would decrease PTHrP expression and therefore osteolytic bone destruction. "
09/15/2009 - "To study the role of PTHrP in early breast cancer, the effect of conditional deletion of PTHrP was examined in the context of neu-induced mammary tumorigenesis. "
09/05/2008 - "In this study, we confirmed that the CaR inhibits PTHrP production by MMECs but stimulates PTHrP production by Comma-D cells (immortalized murine mammary cells) and MCF-7 human breast cancer cells. "
|5.||Prostatic Neoplasms (Prostate Cancer)
01/01/2013 - "Our studies show that when compared to LNCaP, NF-κB activity is significantly higher in C4-2B and PC3, and that the activation of NF-κB signaling in prostate cancer cells resulted in the increased expression of the osteoclast inducing genes PTHrP and RANKL. "
07/01/2009 - "In this study, we used the human prostate cancer cell lines C4-2 and PC-3 as model systems to study the effects of PTHrP on these processes. "
09/01/2004 - "In this study, we hypothesized that activation of the CaR transactivates the EGFR or PDGFR, and examined whether transactivation affects PTHrP secretion in PC-3 human prostate cancer cells. "
05/15/2002 - "The human prostate cancer cell line PC-3, which expresses functional PTH/PTHrP receptors, was used as a model to study the effects of PTHrP on prostate cancer cell growth. "
05/01/1998 - "These findings are valuable for designing future research studies to further elucidate the biological functions of PTHrP in normal prostatic glands and prostate cancer."
|2.||Parathyroid Hormone-Related Protein
|3.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|6.||Parathyroid Hormone (Parathormone)
|7.||Messenger RNA (mRNA)
|8.||Interleukin-6 (Interleukin 6)
|9.||Transforming Growth Factor beta (TGF-beta)
|10.||Complementary DNA (cDNA)
|1.||Heterologous Transplantation (Xenotransplantation)
|4.||Drug Therapy (Chemotherapy)
|5.||Prostheses and Implants (Prosthesis)