Type 1 Galanin Receptor

The most abundant galanin receptor subtype. It displays a high affinity for the full-length form of GALANIN.

Also Known As:

Receptor, Galanin, Type 1; GALR1 Galanin Receptor; Galanin-1 Receptor; Galanin 1 Receptor; Galanin Receptor, GALR1; Receptor 1, Galanin; Receptor, GALR1 Galanin; Receptor, Galanin-1; Galanin Receptor 1

Networked: 26 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - G-Protein-Coupled Receptors: 4701
        Galanin Receptors: 151
        Type 1 Galanin Receptor: 26

Experts

1.	Carey, Thomas E: 4 articles (01/2017 - 06/2005)
2.	Kanazawa, Takeharu: 3 articles (01/2017 - 12/2008)
3.	Misawa, Kiyoshi: 3 articles (01/2017 - 12/2008)
4.	Bo, Ping: 2 articles (01/2018 - 01/2016)
5.	Fang, Penghua: 2 articles (01/2018 - 01/2016)
6.	Shi, Mingyi: 2 articles (01/2018 - 01/2016)
7.	Zhang, Zhenwen: 2 articles (01/2018 - 01/2016)
8.	Zhu, Yan: 2 articles (01/2018 - 01/2016)
9.	Mineta, Hiroyuki: 2 articles (01/2017 - 12/2008)
10.	Misawa, Yuki: 2 articles (01/2017 - 12/2008)

Related Diseases

1.	Insulin Resistance 01/01/2016 - "The aim of the study was further to investigate whether central M617, a galanin receptor 1 agonist, can benefit insulin sensitivity. " 01/01/2016 - "These results suggest that excitation of central galanin receptor 1 facilitates insulin sensitivity via activation of the Akt/AS160 signaling pathway in the fat cells of type 2 diabetic rats." 01/01/2016 - "Central Administration of Galanin Receptor 1 Agonist Boosted Insulin Sensitivity in Adipose Cells of Diabetic Rats." 01/01/2018 - "The results of our and other's studies showed that activation of galanin receptor 1 could mitigate insulin resistance via promoting glucose transporter 4 (GLUT4) expression and translocation in the skeletal muscle of rats. " 10/01/2016 - "This study investigates whether type 1 galanin receptor (GAL1) in the brain mediates the ameliorative effect of galanin on insulin resistance in skeletal muscles of type 2 diabetic rats. "
2.	Neuralgia (Stump Neuralgia) 01/01/2003 - "In the present study, we assessed the nociceptive sensitivity in mice lacking the galanin receptor 1 gene (Galr1) and the development of neuropathic pain-like behaviours after photochemically induced partial sciatic nerve ischaemic injury. " 01/01/2019 - "Galanin receptor 1 plays an antinociceptive effect via inhibiting PKA activation in the nucleus accumbens of rats with neuropathic pain." 10/01/2015 - "Antinociceptive roles of galanin receptor 1 in nucleus accumbens of rats in a model of neuropathic pain." 01/01/2003 - "Hyperalgesia and increased neuropathic pain-like response in mice lacking galanin receptor 1 receptors." 01/01/2019 - "This study investigated the antinociception induced by galanin receptor 1 (GalR1) via protein kinase A (PKA) signaling pathway in the nucleus accumbens (NAc) of rats with neuropathic pain. "
3.	Head and Neck Neoplasms (Head and Neck Cancer) 12/01/2008 - "Epigenetic inactivation of galanin receptor 1 in head and neck cancer." 01/01/2017 - "The aim of this study was to evaluate the prognostic value of the promoter methylation status of galanin (GAL) and galanin receptor 1/2 (GALR1/2) by assessing their association with disease-free survival and known prognostic factors in head and neck cancer. "
4.	Squamous Cell Carcinoma of Head and Neck 12/01/2008 - "One copy of the galanin receptor 1 (GALR1) locus on 18q is often deleted and expression is absent in some head and neck squamous cell carcinoma (HNSCC) cell lines. " 08/23/2007 - "Galanin receptor 1 (GALR1) maps to a common region of 18q loss in head and neck squamous cell carcinomas and is frequently inactivated by methylation. " 06/17/2005 - "Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma." 03/01/2010 - "Our aim is to examine galanin receptor 1 (GALR1) and galanin receptor 2 (GALR2) as HNSCC therapeutic targets and explore opportunities and strategies for making use of GALR1 and GALR2 signaling. "
5.	Hyperalgesia 01/01/2003 - "Hyperalgesia and increased neuropathic pain-like response in mice lacking galanin receptor 1 receptors." 09/01/2004 - "Antinociceptive effects of galanin in the rat tuberomammillary nucleus and the plasticity of galanin receptor 1 during hyperalgesia." 04/05/2012 - "The results showed that (1) the diabetic rats showed a significant mechanical hyperalgesia between 4 and 12weeks; (2) galanin receptor 1 expression decreased in SDH in diabetic rats; (3) galanin receptor 2 expression decreased in DRG and SDH in diabetic rats; (4) intrathecal administration of exogenous galanin attenuated diabetic neuropathic pain, this effect could be blocked by pre-treatment with galanin receptor antagonist M35; and (5) intrathecal administration of galanin receptor 1 agonist M617, but not galanin receptor 2 agonist AR-M1896, attenuated diabetic neuropathic pain. "

Related Drugs and Biologics

1.	Galanin
2.	Facilitative Glucose Transport Proteins (Glucose Transporter)
3.	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)
4.	Neuropeptides
5.	Type 2 Galanin Receptor
6.	NF-kappa B (NF-kB)
7.	Type 1 Angiotensin Receptor
8.	Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)
9.	Galanin Receptors (Galanin Receptor)
10.	Cannabinoid Receptors (Cannabinoid Receptor)