Tetrahydroisoquinolines

09/01/2009 - "Although the behavioural consequences of systemic or intracerebral SAL administrations have been described, the neurochemical effects of pharmacologically relevant doses of SAL and other tetrahydroisoquinolines (THIQs) in the brain areas involved in alcohol addiction are practically unknown. "
05/01/1996 - "Tetrahydroisoquinolines and alcoholism: where are we today?"
09/01/1995 - "Tetrahydroisoquinolines (TIQs) are thought to play an important role in the process of development of alcohol dependence. "
01/01/1992 - "[Tetrahydroisoquinolines--endogenous products from chronic alcohol abuse]."
05/01/1991 - "This decrease can be cause by the chronic alcohol intake, and can be mediated by the tetrahydroisoquinolines (TIQs) or otherwise be the cause and not the consequence of alcoholism. "

01/01/2015 - "HZ08, a novel tetrahydro-isoquinoline derivate, was discovered to inhibit the MDR in the cancer cell lines of MCF-7/ADM, K562/ADM and KBV in our previous studies. "
01/01/2020 - "Both tetrahydroisoquinolines (THIQs) and oxindoles (OXs) display a broad range of biological activities including anti-cancer activity, and are therefore recognized as two privileged scaffolds in drug discovery. "
01/01/2016 - "Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer."
05/01/2008 - "Tetrahydroisoquinolines (THIs) have demonstrated anti-cancer activity in rodent models of glioma, a form of brain cancer refractory to therapeutic intervention. "

07/01/2003 - "Our data can serve as reference for other studies in humans concerning the etiology of alcoholism or other neurodegenerative diseases with the involvement of tetrahydroisoquinolines."

09/15/2000 - "1,2,3,4-Tetrahydroisoquinolines are considered to play an essential role as neurotoxic compounds in the pathomechanism of Parkinson's disease. "
09/15/2000 - "Development of a method for sample preparation for subsequent identification and measurement of 1,2,3,4-tetrahydroisoquinolines and other potentially neurotoxic compounds by high-performance liquid chromatography with ultraviolet and fluorescence detection in blood plasma of Parkinson's disease patients."
01/01/2000 - "The finding that endogenous tetrahydroisoquinolines may be involved in the etiology of Parkinson's disease suggests that their administration may cause changes resembling those observed in parkinsonian brain. "
12/01/1989 - "[Tetrahydroisoquinolines in connection with Parkinson's disease]."
12/07/2022 - "Quantitative Determination of Endogenous Tetrahydroisoquinolines, Potential Parkinson's Disease Biomarkers, in Mammals."

01/01/2017 - "Synthesis and Biological Evaluations of Ring Substituted Tetrahydroisoquinolines (THIQs) as Anti-Breast Cancer Agents."
10/01/2016 - "Substituted Tetrahydroisoquinolines as Microtubule-destabilizing Agents in Triple Negative Human Breast Cancer Cells."
04/25/2014 - "Synthesis and Pharmacological Evolution of Tetrahydroisoquinolines as Anti Breast Cancer Agents."
01/01/2023 - "Synthesis and biological evaluation of atropisomeric tetrahydroisoquinolines overcoming docetaxel resistance in triple-negative human breast cancer cells."