Cholecystokinin A Receptor

A subtype of cholecystokinin receptor found primarily in the PANCREAS; STOMACH; INTESTINE; and GALLBLADDER. It plays a role in regulating digestive functions such as gallbladder contraction, pancreatic enzyme secretion and absorption in the GASTROINTESTINAL TRACT.

Also Known As:

Networked: 123 relevant articles (1 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Funakoshi, Akihiro: 7 articles (08/2006 - 07/2002)
2.	Miyasaka, Kyoko: 7 articles (08/2006 - 07/2002)
3.	Kanai, Setsuko: 4 articles (08/2006 - 07/2002)
4.	Ohta, Minoru: 4 articles (08/2006 - 07/2002)
5.	Rehfeld, J F: 3 articles (10/2009 - 06/2000)
6.	Samuel, Isaac: 3 articles (11/2004 - 11/2003)
7.	Zaheer, Asgar: 3 articles (11/2004 - 11/2003)
8.	Zaheer, Smita: 3 articles (11/2004 - 11/2003)
9.	Yoshida, Yuki: 3 articles (05/2004 - 10/2003)
10.	D'Amato, M: 3 articles (11/2002 - 03/2001)

Related Diseases

1.	Chronic Pancreatitis 10/01/1998 - "Although blockade of the CCK-A receptor could be considered to exacerbate chronic pancreatitis due to possible inhibition of the trophic action of CCK, our results suggest that CCK-A receptor antagonists may not be detrimental to chronic pancreatitis." 07/01/2002 - "The therapeutic efficacy of a CCK-A receptor antagonist, loxiglumide, in patients with painful acute attacks of chronic pancreatitis was evaluated. " 10/01/1998 - "Effect of FK480, a CCK-A receptor antagonist, on spontaneously developed chronic pancreatitis in WBN/Kob rats." 07/01/2002 - "Clinical evaluation of oral administration of a cholecystokinin-A receptor antagonist (loxiglumide) to patients with acute, painful attacks of chronic pancreatitis: a multicenter dose-response study in Japan."
2.	Pancreatitis 03/01/1997 - "The present studies were undertaken to evaluate the involvement of endogenous CCK and the CCK-A receptors in the development of severe acute pancreatitis induced in Otsuka Long-Evans Tokushima Fatty (OLETF) rats that have a selective defect in the CCK-A receptor. " 03/01/2000 - "The CCK-A receptor antagonist might be therapeutically useful in acute pancreatitis by stopping the vicious circle." 03/01/1998 - "These observations indicate that the absence of the CCK-A receptor did not modify the acute phase of pancreatitis but significantly retarded regeneration of the pancreatic tissue." 10/01/1995 - "Changes in gene expression of cholecystokinin-A receptor after induction of pancreatitis by pancreatic duct occlusion in rats." 01/01/2004 - "CCK-A receptor induction and P38 and NF-kappaB activation in acute pancreatitis."
3.	Gallstones (Gallstone) 11/29/2020 - "An Update on the Lithogenic Mechanisms of Cholecystokinin a Receptor (CCKAR), an Important Gallstone Gene for Lith13." 11/01/2002 - "The genetic variations of cholecystokinin A receptor (CCK-AR) in patients having gallstones and the molecular mechanisms of this polymorhpism were examined. " 05/01/1999 - "The down-regulation of gene expression of CCK-A receptor plays an important role in gallbladder hypomotility in patients with gallstone." 05/01/1999 - "To investigate the expression of CCK-A receptor and its relation with gallbladder hypomotility in patients with gallstone. " 05/01/1999 - "[Correlation between gene expression of CCK-A receptor and gallbladder emptying in gallstone patients]."
4.	Schizophrenia (Dementia Praecox) 04/01/2007 - "Association study between the cholecystokinin A receptor gene and schizophrenia in the Japanese population." 07/01/2015 - "Cholecystokinin A receptor (CCK-AR) gene polymorphism is being increasingly reported in schizophrenia. " 10/01/2014 - "To find the risk loci on cholecystokinin A receptor gene (CCKAR) - a schizophrenia candidate gene by using the deep sequencing and then analyze the variations. " 10/01/2014 - "[Deep sequencing for cholecystokinin a receptor gene to get loci associated with schizophrenia]." 10/01/2009 - "An intron 1 polymorphism in the cholecystokinin-A receptor gene associated with schizophrenia in males."
5.	Anorexia 10/01/2007 - "The present study assessed the dose-dependency of this response and the effect of two selective CCK(1) receptor antagonists, with different abilities to cross the blood-brain barrier (BBB), on PEG-CCK(9)-induced anorexia. " 03/05/2008 - "Jejunal LA infusion also reduced food intake in CCK-A receptor-deficient OLETF rats, suggesting that CCK signaling pathway is not critical for intestinal LCFA-induced anorexia. " 03/17/1994 - "The present study compared the patterns of c-fos protein-like immunoreactivity (FLI) induced in rat brain by CCK and the indirect 5HT agonist dexfenfluramine (DFEN), as well as the ability for devazepide, a CCK-A receptor antagonist, to antagonize both anorexia and FLI induced by these agents. " 05/01/2000 - "To test the possibility that cholecystokinin (CCK) mediates anorexia induced by IL-1 beta and LPS, mice trained to poke their noses in a hole to obtain a food reward according to a fixed ratio (1 reward per 20 actions) were pretreated with the CCK-A receptor antagonist L364,718 (at 1 mg/kg) or with the CCK-B receptor antagonist L365,260 (50 microg/kg) before being injected with LPS (100 microg/kg) or IL-1 beta (20 microg/kg). " 03/01/1999 - "Devazepide, a CCK(A) receptor antagonist, appeared to interact with tropisetron in the anorectic responses to IMB, blunting the usual remediation of IMB anorexia by tropisetron. "

Related Drugs and Biologics

1.	loxiglumide
2.	Cholecystokinin (Pancreozymin)
3.	Messenger RNA (mRNA)
4.	Cholecystokinin B Receptor
5.	Cholecystokinin A Receptor
6.	Devazepide
7.	Gastrins
8.	FR 120480
9.	Proteins (Proteins, Gene)
10.	8-sulfocholecystokinin octapeptide

Related Therapies and Procedures

1.	Ligation
2.	Injections
3.	Oral Administration
4.	Therapeutics
5.	Electroacupuncture