Bradykinin B1 Receptor

A subtype of BRADYKININ RECEPTOR that is induced in response to INFLAMMATION. It may play a role in chronic inflammation and has a high specificity for KININS lacking the C-terminal ARGININE such as des-Arg(10)-kallidin and des-Arg(9)-bradykinin. The receptor is coupled to G-PROTEIN, GQ-G11 ALPHA FAMILY and G-PROTEIN, GI-GO ALPHA FAMILY signaling proteins.

Also Known As:

Networked: 76 relevant articles (4 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sirois, Pierre: 8 articles (09/2011 - 12/2002)
2.	Gabra, Bichoy H: 6 articles (02/2006 - 12/2002)
3.	Bénard, François: 5 articles (01/2017 - 03/2015)
4.	Lin, Kuo-Shyan: 5 articles (01/2017 - 03/2015)
5.	Pan, Jinhe: 5 articles (01/2017 - 03/2015)
6.	Colpo, Nadine: 4 articles (01/2017 - 03/2015)
7.	Amouroux, Guillaume: 4 articles (01/2016 - 03/2015)
8.	Liu, Zhibo: 4 articles (01/2016 - 03/2015)
9.	Zhang, Zhengxing: 4 articles (01/2016 - 03/2015)
10.	Chen, Jian Jeffrey: 4 articles (08/2010 - 01/2007)

Related Diseases

1.	Hyperalgesia 02/01/2006 - "We discuss the efficacy of selective antagonists of the inducible bradykinin B1 receptor (BKB1-R) subtype against hyperalgesia assessed by various nociceptive tests. " 01/01/2015 - "The bradykinin B1 receptor antagonist BI113823 reverses inflammatory hyperalgesia by desensitization of peripheral and spinal neurons." 05/02/2005 - "Hyperalgesia in non-obese diabetic (NOD) mice: a role for the inducible bradykinin B1 receptor." 04/15/2005 - "Absence of diabetic hyperalgesia in bradykinin B1 receptor-knockout mice." 12/01/2004 - "Pathways for the bradykinin B1 receptor-mediated diabetic hyperalgesia in mice."
2.	Inflammation (Inflammations) 01/01/2015 - "The up-regulation of the bradykinin B1 receptor in response to inflammation makes it an attractive target for drug development. " 05/03/2007 - "The bradykinin B1 receptor is induced following tissue injury and/or inflammation. " 12/18/2000 - "The bradykinin B1 receptor is thought to be induced by tissue injury and inflammation. " 02/15/1998 - "Bradykinin B1 receptor (BKB1R) is involved in a variety of pathophysiological processes, particularly those related to inflammation. " 06/01/1996 - "Bradykinin B1 receptors have been identified in a limited number of human tissues and may have implications in pathological states of chronic inflammation. "
3.	Pain (Aches) 08/01/2010 - "The bradykinin B1 receptor has been shown to mediate pain response and is rapidly induced upon injury. " 01/01/2007 - "Targeting the bradykinin B1 receptor to reduce pain." 11/01/2005 - "With a mouse model of bone cancer pain we demonstrate that pharmacologic blockade of the bradykinin B1 receptor is effective in reducing bone cancer pain-related behaviors, suggesting that B1 antagonists might be useful in attenuating bone cancer pain in humans." 08/01/2000 - "Bradykinin B1 receptors also produce inflammation and pain. " 11/01/2005 - "In our model of bone cancer, which involves the injection and confinement of 2472 sarcoma cells to the mouse femur, pharmacologic blockade of the bradykinin B1 receptor is effective in reducing pain-related behaviors at both early and advanced stages of bone cancer. "
4.	Sarcoma (Soft Tissue Sarcoma) 11/01/2005 - "In our model of bone cancer, which involves the injection and confinement of 2472 sarcoma cells to the mouse femur, pharmacologic blockade of the bradykinin B1 receptor is effective in reducing pain-related behaviors at both early and advanced stages of bone cancer. "
5.	Insulin Resistance 01/01/2017 - "Antagonizing bradykinin type 1 receptor (B1R) improved body and tissue fat mass and reversed vascular and adipose tissue inflammation in a rat model of insulin resistance. " 01/01/2017 - "Bradykinin type 1 receptor antagonism could represent a promising therapeutic tool in combination with TZD for the treatment of T2D, obesity and insulin resistance."

Related Drugs and Biologics

1.	Streptozocin (Streptozotocin)
2.	Bradykinin B2 Receptor
3.	Bradykinin
4.	icatibant
5.	Bradykinin Receptors (Bradykinin Receptor)
6.	Dexamethasone (Maxidex)
7.	Bradykinin Receptor Antagonists
8.	Lipopolysaccharides
9.	Angiotensin II
10.	R 715

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)
2.	Intra-Articular Injections