Adenosine A2B Receptor

A subclass of adenosine A2 receptors found in the CECUM, the COLON, the BLADDER, and a variety of other tissues. It is generally considered to be a low affinity receptor for ADENOSINE that couples to the GS, STIMULATORY G-PROTEIN.

Also Known As:

Networked: 99 relevant articles (6 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Eltzschig, Holger K: 10 articles (04/2022 - 09/2003)
2.	Xia, Yang: 7 articles (01/2021 - 12/2013)
3.	Müller, Christa E: 5 articles (06/2022 - 08/2011)
4.	Kellems, Rodney E: 5 articles (01/2021 - 06/2014)
5.	Blackburn, Michael R: 5 articles (08/2016 - 12/2013)
6.	Brust, Peter: 4 articles (04/2022 - 01/2020)
7.	Deuther-Conrad, Winnie: 4 articles (04/2022 - 01/2020)
8.	Liu, Hong: 4 articles (01/2021 - 01/2016)
9.	Zhang, Yujin: 4 articles (01/2021 - 06/2014)
10.	Linden, Joel: 4 articles (01/2020 - 02/2011)

Related Diseases

1.	Obesity 04/05/2022 - "Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity." 01/01/2020 - "Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity." 11/03/2022 - "Preliminary Evidence of the Potent and Selective Adenosine A2B Receptor Antagonist PSB-603 in Reducing Obesity and Some of Its Associated Metabolic Disorders in Mice." 01/01/2020 - "Here, we show that the enigmatic adenosine A2B receptor (A2B) is abundantly expressed in skeletal muscle (SKM) as well as brown adipose tissue (BAT) and might be targeted to counteract age-related muscle atrophy (sarcopenia) as well as obesity. "
2.	Hypoxia (Hypoxemia) 01/01/2021 - "Recent studies revealed that signaling through the erythrocyte adenosine A2B receptor (ADORA2B) promotes O2 release to counteract hypoxia at high altitude. " 11/01/2006 - "Initial studies confirmed previous findings indicating selective induction of human adenosine A2B receptor (A2BR) by hypoxia. " 11/01/2006 - "HIF-dependent induction of adenosine A2B receptor in hypoxia." 11/01/2010 - "Hypoxia-inducible adenosine A2B receptor modulates proliferation of colon carcinoma cells." 01/01/2021 - "Sevoflurane induced the expression of hypoxia-inducible factor 1α and adenosine A2B receptor in the intestine, liver, and lung. "
3.	Reperfusion Injury 10/01/2010 - "This study tests the hypothesis that the adenosine A(2B) receptor exacerbates the proinflammatory response to lung ischemia-reperfusion injury. " 08/01/2016 - "Attenuation of Pulmonary Ischemia-Reperfusion Injury by Adenosine A2B Receptor Antagonism." 11/15/2012 - "In vivo hypoxic preconditioning protects from warm liver ischemia-reperfusion injury through the adenosine A2B receptor." 10/01/2010 - "Tissue-derived proinflammatory effect of adenosine A2B receptor in lung ischemia-reperfusion injury." 03/01/2013 - "We tested whether protection against reperfusion injury by ischemic postconditioning (IPost), soluble guanylyl cyclase (sGC) activation and inhibition, adenosine A(2B) receptor (A(2B)AR) agonist, phosphodiesterase type-5 (PDE-5) inhibitor, or mitochondria-targeted S-nitrosothiol (MitoSNO) was affected by a cardiomyocyte-specific ablation of the PKGI gene in the mouse (CMG-KO). "
4.	Ischemia 10/01/2010 - "Adenosine A(2B) receptor knockout → adenosine A(2B) receptor knockout (donor → recipient) and wild-type → adenosine A(2B) receptor knockout, but not adenosine A(2B) receptor knockout → wild-type, chimeras showed significantly improved lung function after ischemia-reperfusion. " 01/01/2014 - "Adenosine A2B receptor modulates intestinal barrier function under hypoxic and ischemia/reperfusion conditions." 10/01/2010 - "Adenosine A(2B) receptor may provide a therapeutic target for prevention of ischemia-reperfusion-related graft dysfunction in lung transplant recipients." 10/01/2010 - "An in vivo left lung hilar clamp model of ischemia-reperfusion was used in wild-type C57BL6 and adenosine A(2B) receptor knockout mice, and in chimeras created by bone marrow transplantation between wild-type and adenosine A(2B) receptor knockout mice. " 01/01/2018 - "The selective antagonists of the adenosine A2B receptor subtype may thus represent a new class of neuroprotective drugs in ischemia."
5.	Colitis 09/01/2008 - "Blockade of adenosine A2B receptors ameliorates murine colitis." 04/15/2009 - "Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis."

Related Drugs and Biologics

1.	S-Nitrosothiols
2.	Phosphoric Diester Hydrolases (Phosphodiesterases)
3.	Sevoflurane (Ultane)
4.	Soluble Guanylyl Cyclase
5.	psb-603
6.	Therapeutic Uses
7.	Glucose (Dextrose)
8.	Netrin Receptors
9.	Netrins
10.	neogenin

Related Therapies and Procedures

1.	Ischemic Postconditioning
2.	Therapeutics
3.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
4.	Lasers (Laser)
5.	Immunotherapy