Adenosine A1 Receptor

A subtype of ADENOSINE RECEPTOR that is found expressed in a variety of tissues including the BRAIN and DORSAL HORN NEURONS. The receptor is generally considered to be coupled to the GI, INHIBITORY G-PROTEIN which causes down regulation of CYCLIC AMP.

Also Known As:

Networked: 535 relevant articles (38 outcomes, 69 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Li, Tianfu: 7 articles (03/2022 - 05/2007)
2.	May, Lauren T: 7 articles (01/2022 - 09/2015)
3.	Boison, Detlev: 6 articles (03/2022 - 07/2003)
4.	Christopoulos, Arthur: 6 articles (01/2022 - 09/2015)
5.	White, Paul J: 6 articles (01/2022 - 09/2010)
6.	Voors, Adriaan A: 6 articles (11/2019 - 05/2011)
7.	Mirnajafi-Zadeh, Javad: 6 articles (02/2013 - 01/2006)
8.	Scammells, Peter J: 5 articles (01/2022 - 09/2010)
9.	Jacobson, Kenneth A: 5 articles (10/2021 - 08/2015)
10.	Ponikowski, Piotr: 5 articles (01/2017 - 05/2011)

Related Diseases

1.	Ischemia 03/01/1997 - "Protection against global ischemia in the rabbit isolated heart 24 hours after transient adenosine A1 receptor activation." 04/01/1998 - "Pretreatment with either multiple episodes of ischemia or continuous infusion of a selective adenosine A1 receptor agonist, 2-chloro-N6-cyclopentyladenosine (CCPA), resulted in attenuation of the protective effects of preconditioning, implying downregulation of the receptors involved in triggering classic preconditioning. " 08/01/2008 - "These results indicate that D1R activation presynaptically depresses excitatory synaptic transmission in striatal neurons after ischemia through activation of PKA and adenosine A1 receptors and thus demonstrate a novel mechanism of D1R-mediated protection against ischemia." 01/01/2015 - "As the adenosine A1 receptor activation confers protection against ischemia/reperfusion (I/R)-induced ventricular arrhythmias, we hypothesized that CBD may have antiarrhythmic effect through the activation of adenosine A1 receptor. " 12/01/1998 - "Overexpressing the adenosine A1 receptor also led to increased protection against ischemia-induced myocyte injury as well as an enhanced preconditioning effect. "
2.	Hypoxia (Hypoxemia) 01/01/2001 - "These results confirm the important role of adenosine A1 receptor agonist in protection against acute and chronic epileptogenic effect of hypoxia. " 03/01/2016 - "This study demonstrates that tonic activation of adenosine A1 receptors (A1 R) plays an important role in the reoxygenation recovery of the metabolic alterations caused by transient hypoxia in rat hippocampal slices. " 11/01/2008 - "This study examined the effect of SF on ventilatory long-term facilitation (LTF, a persistent augmentation of respiratory activity after episodic hypoxia) and the hypoxic ventilatory response (HVR), and investigated the role of adenosine A1 receptors in these SF effects in conscious adult male Sprague-Dawley rats. " 09/01/2018 - "Activating adenosine A1 receptor accelerates PC12 cell injury via ADORA1/PKC/KATP pathway after intermittent hypoxia exposure." 09/28/2006 - "Respiratory and body temperature modulation by adenosine A1 receptors in the anteroventral preoptic region during normoxia and hypoxia."
3.	Seizures (Absence Seizure) 05/01/2008 - "In this study, the role of adenosine A1 receptors of piriform cortex on CA1 hippocampal kindled seizures was studied in rats. " 06/22/2007 - "In this study, the effect of amygdala kindled seizures on adenosine A1 receptor-mediated neuromodulation in piriform cortex pyramidal neurons was tested at 24 h and 1 month after kindling. " 12/01/2006 - "In this study, the role of adenosine A1 receptors of the hippocampal CA1 region in entorhinal cortex-kindled seizures was investigated in rats. " 08/01/2017 - "Activation of adenosine A1 receptors (A1R) has been proven to prevent the spatial spread of seizures. " 04/01/2015 - "Our findings indicate that the activation of adenosine A1 receptors is an important mechanism to control the development of seizures in zebrafish. "
4.	Infarction (Infarctions) 12/01/1995 - "The purpose of this study was to compare the cardioprotective effects of ischemic preconditioning and an adenosine A1 receptor agonist on recovery of function and infarct size in isolated rabbit hearts. " 09/01/1999 - "1. Cardioprotection by adenosine A1 receptor activation limits infarct size and improves post-ischaemic mechanical function. " 01/01/1997 - "Stimulation of adenosine A1 receptors is known to reduce infarct size in the rabbit heart. " 04/01/1993 - "This finding confirms a genuine anti-infarct effect of adenosine A1 receptor stimulation when given prior to the onset of ischaemia. " 12/01/2000 - "We designed a three-center experimental study using a blinded, randomized treatment protocol to test the hypothesis that adenosine A1 receptor activation during early reperfusion can attenuate lethal reperfusion injury, thereby reducing infarct size. "
5.	Neuralgia (Stump Neuralgia) 01/01/2021 - "Lack of efficacy of a partial adenosine A1 receptor agonist in neuropathic pain models in mice." 09/01/2015 - "A Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain Model." 05/09/2005 - "Adenosine A1 receptor partial agonists behave as full agonists with regard to the anti-hyperalgesic effect in neuropathic pain, but the anti-nociceptive effect is diminished." 05/09/2005 - "The objective of this investigation was to characterise the pharmacokinetic-pharmacodynamic correlation of adenosine A1 receptor partial agonists in the chronic constriction injury model of neuropathic pain. " 05/09/2005 - "Pharmacokinetic/pharmacodynamic modelling of the anti-hyperalgesic and anti-nociceptive effect of adenosine A1 receptor partial agonists in neuropathic pain."

Related Drugs and Biologics

1.	Adenosine (Adenocard)
2.	Sarin
3.	N(6)-cyclopentyladenosine
4.	1,3-dipropyl-8-cyclopentylxanthine
5.	Adenosine A2A Receptor (Adenosine A2A Receptors)
6.	neladenoson bialanate
7.	N-(1-methyl-2-phenylethyl)adenosine (S-PIA)
8.	GTP-Binding Proteins (G-Protein)
9.	Pentylenetetrazole (Metrazol)
10.	Anticonvulsants (Antiepileptic Drugs)

Related Therapies and Procedures

1.	Electroacupuncture
2.	Acupuncture Points (Acupuncture Point)
3.	Controlled Hypotension
4.	Aftercare (After-Treatment)
5.	Topical Administration