Muscarinic M5 Receptor

A specific subtype of muscarinic receptor found in a variety of locations including the SALIVARY GLANDS and the SUBSTANTIA NIGRA and VENTRAL TEGMENTAL AREA of the BRAIN.

Also Known As:

Receptor, Muscarinic M5; M5 Muscarinic Receptor; Receptors, Muscarinic M5; M5 Receptor, Muscarinic; M5 Receptors, Muscarinic; M5, Muscarinic Receptor; M5, Muscarinic Receptors; Muscarinic M5 Receptors; Muscarinic Receptor, M5; Receptor M5, Muscarinic; Receptor, M5 Muscarinic; Receptors M5, Muscarinic; Muscarinic Receptor M5; Muscarinic Receptors M5

Networked: 10 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - G-Protein-Coupled Receptors: 4701
        Muscarinic Receptors: 2434
        Muscarinic M5 Receptor: 10
      - Neurotransmitter Receptors: 562
        Cholinergic Receptors: 3880
        Muscarinic Receptors: 2434
        Muscarinic M5 Receptor: 10

Experts

1.	Amthor, Franklin R: 1 article (01/2015)
2.	Gavrikov, Konstantin E: 1 article (01/2015)
3.	Keyser, Kent T: 1 article (01/2015)
4.	Long, Ye: 1 article (01/2015)
5.	Strang, Christianne E: 1 article (01/2015)
6.	Aronsson, Patrik: 1 article (01/2014)
7.	Johnsson, Martin: 1 article (01/2014)
8.	Tayem, Yasin: 1 article (01/2014)
9.	Tobin, Gunnar: 1 article (01/2014)
10.	Vesela, Renata: 1 article (01/2014)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 12/01/2004 - "Decreased amphetamine-induced locomotion and improved latent inhibition in mice mutant for the M5 muscarinic receptor gene found in the human 15q schizophrenia region."
2.	Melanoma (Melanoma, Malignant) 07/19/1996 - "Identification and molecular characterization of a m5 muscarinic receptor in A2058 human melanoma cells. " 02/15/1994 - "Compounds were tested for the inhibition of calcium influx and arachidonic acid release and inhibition of proliferation and colony formation in soft agar using the malignant CHO line transfected with the m5 muscarinic receptor and the A2058 human melanoma cell line. "
3.	Astrocytoma (Pilocytic Astrocytoma) 02/22/1996 - "Reverse transcription-polymerase chain reaction (RT-PCR) experiments indicated the presence of m2, m3 and to a lesser degree, m5 muscarinic receptor mRNA in both astrocytes and astrocytoma cells. " 11/15/2000 - "In the present paper, we showed that in 123-1N1 human astrocytoma cells, which express the G-protein-coupled M2, M3, and M5 muscarinic receptors, PKC zeta is activated by carbachol in a concentration-dependent manner, resulting in the translocation of PKC zeta from the cytoplasm to granules in the perinuclear region. "
4.	Ganglion Cysts (Ganglion) 01/01/2015 - "Specifically, the expression patterns of m1, m4, and m5 muscarinic receptors overlapped with those of non-α7 and α7 nicotinic receptors in presumptive amacrine and ganglion cells. "
5.	Substance-Related Disorders (Drug Abuse) 12/01/2009 - "The M5 muscarinic receptor as possible target for treatment of drug abuse."

Related Drugs and Biologics

1.	Amphetamine (Amfetamine)
2.	GTP-Binding Proteins (G-Protein)
3.	Nitric Oxide Synthase (NO Synthase)
4.	Arachidonic Acid (Vitamin F)
5.	Messenger RNA (mRNA)
6.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
7.	Nitric Oxide (Nitrogen Monoxide)
8.	Cyclophosphamide (Cytoxan)
9.	Carbachol (Carbastat)
10.	Calcium