20-alpha-Hydroxysteroid Dehydrogenase

An enzymes that catalyzes the reversible reduction-oxidation reaction of 20-alpha-hydroxysteroids, such as from PROGESTERONE to 20-ALPHA-DIHYDROPROGESTERONE.

Also Known As:

17 beta, 20 alpha-Hydroxysteroid Dehydrogenase; 20 alpha-Hydroxysteroid Dehydrogenase; 20-alpha-HSD; NADPH-Dependent 20 alpha-Hydroxysteroid Oxidoreductase; 17 beta, 20 alpha Hydroxysteroid Dehydrogenase; 20 alpha HSD; 20 alpha Hydroxysteroid Dehydrogenase; NADPH Dependent 20 alpha Hydroxysteroid Oxidoreductase

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Alcohol Oxidoreductases: 56
      - Carbohydrate Dehydrogenases
        Sugar Alcohol Dehydrogenases
        Aldo-Keto Reductases: 299
        20-alpha-Hydroxysteroid Dehydrogenase: 10
        20 alpha-dihydroprogesterone dehydrogenase
      - NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases
        Aldo-Keto Reductases: 299
        20-alpha-Hydroxysteroid Dehydrogenase: 10
        20 alpha-dihydroprogesterone dehydrogenase
        20-Hydroxysteroid Dehydrogenases
        20-alpha-Hydroxysteroid Dehydrogenase: 10
        20 alpha-dihydroprogesterone dehydrogenase

Experts

1.	Beyenburg, Stefan: 1 article (04/2003)
2.	Bidlingmaier, Frank: 1 article (04/2003)
3.	Casarosa, Elena: 1 article (04/2003)
4.	Clusmann, Hans: 1 article (04/2003)
5.	Elger, Christian E: 1 article (04/2003)
6.	Ludwig, Michael: 1 article (04/2003)
7.	Luisi, Stefano: 1 article (04/2003)
8.	Steckelbroeck, Stephan: 1 article (04/2003)
9.	Stoffel-Wagner, Birgit: 1 article (04/2003)
10.	Watzka, Matthias: 1 article (04/2003)

Related Diseases

1.	Temporal Lobe Epilepsy 04/01/2003 - "The aim of the present study was to investigate the mRNA expression of 5 alpha-reductase 1 as well as 3 alpha-HSD 1, 2, 3 and 20 alpha-HSD in brain tissue from patients with pharmacoresistant temporal lobe epilepsy (TLE). "
2.	Neoplasms (Cancer) 06/01/1994 - "Thus, 20 alpha-HSD activity was found in neoplastic tissues at a considerable high rate and the activity seemed to be higher in pathologically malignant tumors." 06/01/1994 - "Comparing with the activity of normal tissues examined, the corresponding tumor tissues showed significantly higher 20 alpha-HSD activities. " 06/01/1994 - "Among these tumors, mixed tumor types demonstrated the higher 20 alpha-HSD activity than epithelial and non-epithelial types, and malignant tumors of each tissue type showed slightly but not significantly higher 20 alpha-HSD activities comparing with the corresponding benign ones. " 06/01/1994 - "Forty-eight of 57 tumor samples were shown to possess 20 alpha-HSD activity. " 06/01/1994 - "20 alpha-hydroxysteroid dehydrogenase activity in canine spontaneous neoplasms."
3.	Lymphoma (Lymphomas) 03/01/1985 - "The subset of T-cell involved was influenced by the genotype since lymphomas arising after the transfer of CBA and BALB/c spleens were TdT positive and 20 alpha-hydroxysteroid dehydrogenase positive, respectively. " 03/01/1985 - "Such lymphomas arise from at least two subsets of T-cells, one terminal deoxynucleotidyl transferase (TdT) positive and the other 20 alpha-hydroxysteroid dehydrogenase positive. " 02/15/1982 - "The T-cell enzyme markers, terminal deoxy-nucleotidyltransferase (TDT) and 20 alpha hydroxysteroid dehydrogenase (20 alpha SDH), were used to classify lymphomas induced by the Moloney leukemia virus (M-MuLV). "
4.	Osteosarcoma (Osteogenic Sarcoma) 07/01/1996 - "Effects of 20 alpha-hydroxysteroid dehydrogenase and its inhibitors on canine osteosarcoma cell growth in vitro." 07/01/1996 - "From these results, POS osteosarcoma cells have 20 alpha-HSD, which might play an important role in tumor cell growth against the cell toxicity of progesterone."
5.	Hemolysis 10/15/1980 - "20 alpha-hydroxysteroid dehydrogenase was found in the supernatant after hemolysis of human erythrocytes, and the enzyme was isolated from the membrane-free hemolysate on a DEAE-cellulose column. "

Related Drugs and Biologics

1.	Cholestenone 5 alpha-Reductase (5 alpha-Reductase)
2.	Messenger RNA (mRNA)
3.	Enzymes
4.	3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)
5.	NADP (NADPH)
6.	Proteins (Proteins, Gene)
7.	Progesterone
8.	Nucleotidyltransferases
9.	Mixed Function Oxygenases (Monooxygenases)
10.	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)