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DNA-(Apurinic or Apyrimidinic Site) Lyase (AP Endonuclease)

A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.
Also Known As:
AP Endonuclease; AP Lyase; Apurine-Apyrimidine Endonuclease; Apurinic Endonuclease; Apurine Apyrimidine Endonuclease; DNA Endonuclease, Apurinic; Endonuclease, AP; Endonuclease, Apurine-Apyrimidine; Endonuclease, Apurinic; Endonuclease, Apurinic DNA; Apurinic DNA Endonuclease; DNA Lyase (Apurinic or Apyrimidinic); Endodeoxyribonuclease (Apurinic or Apyrimidinic)
Networked: 80 relevant articles (3 outcomes, 7 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Wang, Dong: 4 articles (12/2011 - 06/2004)
2. Silber, John R: 3 articles (06/2015 - 09/2002)
3. Mitra, Sankar: 3 articles (01/2013 - 03/2008)
4. Bohr, Vilhelm A: 2 articles (10/2015 - 01/2007)
5. Madhusudan, Srinivasan: 2 articles (12/2014 - 08/2010)
6. Yang, Xiaoming: 2 articles (10/2014 - 06/2005)
7. Ramotar, Dindial: 2 articles (10/2014 - 06/2005)
8. Tell, Gianluca: 2 articles (03/2014 - 11/2010)
9. Bhakat, Kishor K: 2 articles (01/2013 - 03/2008)
10. Wilson, David M: 2 articles (04/2012 - 01/2007)

Related Diseases

1. Neoplasms (Cancer)
2. Carcinoma (Carcinomatosis)
3. Myocardial Ischemia (Ischemic Heart Diseases)
4. Colorectal Neoplasms (Colorectal Cancer)
5. Xeroderma Pigmentosum (Kaposi's Disease)

Related Drugs and Biologics

1. DNA Glycosylases (DNA Glycosylase)
2. 8-hydroxyguanine
3. Carotenoids (Carotene)
4. A-Form DNA (A-DNA)
5. DNA (Deoxyribonucleic Acid)
6. Enzymes
7. Uracil-DNA Glycosidase
8. RNA (Ribonucleic Acid)
9. Methyl Methanesulfonate
10. Exonucleases (3' 5' Exonuclease)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Radiotherapy