HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

5-alpha-Dihydroprogesterone (5 alpha-Dihydroprogesterone)

A biologically active 5-alpha-reduced metabolite of plasma PROGESTERONE. It is the immediate precursor of 5-alpha-pregnan-3-alpha-ol-20-one (ALLOPREGNANOLONE), a neuroactive steroid that binds with GABA(A) RECEPTOR.
Also Known As:
5 alpha-Dihydroprogesterone; 3,20-Allopregnanedione; 3,20-Allopregnanedione, (5alpha)-Isomer; 3,20-Allopregnanedione, (5beta,13alpha,17alpha)-Isomer; 5 alpha-Pregnane-3,20-dione; 5 beta-Pregnane-3,20-dione; 5-alpha-Pregnane-3,20-dione; 5-alpha-Pregnanedione; 5-beta-Dihydroprogesterone; 5alpha-DHP; 5alpha-Pregnane-3,20-dione; 5beta-DHP; 3,20 Allopregnanedione; 5 alpha Dihydroprogesterone; 5 alpha Pregnane 3,20 dione; 5 alpha Pregnanedione; 5 beta Dihydroprogesterone; 5 beta Pregnane 3,20 dione; 5alpha DHP; 5alpha Pregnane 3,20 dione; 5beta DHP
Networked: 17 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Wiebe, J P: 4 articles (11/2007 - 06/2000)
2. González-Flores, Oscar: 3 articles (01/2009 - 01/2004)
3. Camacho-Arroyo, Ignacio: 2 articles (01/2009 - 12/2004)
4. Pawlak, K J: 2 articles (11/2007 - 11/2005)
5. Etgen, Anne M: 2 articles (12/2004 - 01/2004)
6. Armengual-Villegas, Alejandra: 1 article (01/2009)
7. García-Juárez, Marcos: 1 article (01/2009)
8. Guerra-Araiza, Christian: 1 article (01/2009)
9. Gómora-Arrati, Porfirio: 1 article (01/2009)
10. Lima-Hernández, Francisco Javier: 1 article (01/2009)

Related Diseases

1. Premenstrual Syndrome (Premenstrual Tension)
2. Lordosis
3. Breast Neoplasms (Breast Cancer)
10/01/2001 - "Tumorous human breast tissue readily converts progesterone to 5alpha-pregnane-3,20-dione (5alphaP), and this metabolite has been shown to stimulate proliferation and to decrease adhesion of MCF-7 breast cancer cells. "
06/16/2000 - "Plasma membrane receptors for the cancer-regulating progesterone metabolites, 5alpha-pregnane-3,20-dione and 3alpha-hydroxy-4-pregnen-20-one in MCF-7 breast cancer cells."
11/01/2007 - "Our previous findings that the progesterone metabolite, 5alpha-pregnane-3,20-dione (5alphaP), exhibits marked mitogenic and metastatic properties, whereas the progesterone metabolites, 4-pregnen-3alpha-ol-20-one (3alphaHP) and 4-pregnen-20alpha-ol-3-one (20alphaHP), oppose these actions, prompted examination of the possible effects of these progesterone metabolites on ER concentration in MCF-7 breast cancer cells. "
06/16/2000 - "Recent observations indicate that the progesterone metabolite, 5alpha-pregnane-3,20-dione (5alphaP), which is produced at higher levels in tumorous breast tissue, promotes cell proliferation and detachment, whereas 3alpha-hydroxy-4-pregnen-20-one (3alphaHP), which is produced at higher levels in nontumorous breast tissue, suppresses proliferation and detachment of MCF-7 breast cancer cells. "
11/01/2005 - "Membrane 5alpha-pregnane-3,20-dione (5alphaP) receptors in MCF-7 and MCF-10A breast cancer cells are up-regulated by estradiol and 5alphaP and down-regulated by the progesterone metabolites, 3alpha-dihydroprogesterone and 20alpha-dihydroprogesterone, with associated changes in cell proliferation and detachment."
4. Neoplasms (Cancer)
5. Pregnancy-Induced Hypertension (Hypertension, Pregnancy Induced)

Related Drugs and Biologics

1. Pregnanolone (Allopregnanolone)
2. Steroids
3. Pregnenolone
4. pregnenolone sulfate
5. Progesterone
6. 3-hydroxypregn-4-en-20-one
7. Progestins (Progestagens)
8. Nitric Oxide Synthase (NO Synthase)
9. Antisense Oligonucleotides
10. Mifepristone (RU 486)