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5-alpha-Dihydroprogesterone (5 alpha-Dihydroprogesterone)

A biologically active 5-alpha-reduced metabolite of plasma PROGESTERONE. It is the immediate precursor of 5-alpha-pregnan-3-alpha-ol-20-one (ALLOPREGNANOLONE), a neuroactive steroid that binds with GABA(A) RECEPTOR.
Also Known As:
5 alpha-Dihydroprogesterone; 3,20-Allopregnanedione; 3,20-Allopregnanedione, (5alpha)-Isomer; 3,20-Allopregnanedione, (5beta,13alpha,17alpha)-Isomer; 5 alpha-Pregnane-3,20-dione; 5 beta-Pregnane-3,20-dione; 5-alpha-Pregnane-3,20-dione; 5-alpha-Pregnanedione; 5-beta-Dihydroprogesterone; 5alpha-DHP; 5alpha-Pregnane-3,20-dione; 5beta-DHP; 3,20 Allopregnanedione; 5 alpha Dihydroprogesterone; 5 alpha Pregnane 3,20 dione; 5 alpha Pregnanedione; 5 beta Dihydroprogesterone; 5 beta Pregnane 3,20 dione; 5alpha DHP; 5alpha Pregnane 3,20 dione; 5beta DHP
Networked: 16 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Wiebe, J P: 4 articles (11/2007 - 06/2000)
2. González-Flores, Oscar: 3 articles (01/2009 - 01/2004)
3. Camacho-Arroyo, Ignacio: 2 articles (01/2009 - 12/2004)
4. Pawlak, K J: 2 articles (11/2007 - 11/2005)
5. Etgen, Anne M: 2 articles (12/2004 - 01/2004)
6. García-Juárez, Marcos: 1 article (01/2009)
7. Miranda-Martínez, Alfredo: 1 article (01/2009)
8. Gómora-Arrati, Porfirio: 1 article (01/2009)
9. Lima-Hernández, Francisco Javier: 1 article (01/2009)
10. Guerra-Araiza, Christian: 1 article (01/2009)

Related Diseases

1. Premenstrual Syndrome (Premenstrual Tension)
2. Lordosis
3. Breast Neoplasms (Breast Cancer)
11/01/2007 - "Our previous findings that the progesterone metabolite, 5alpha-pregnane-3,20-dione (5alphaP), exhibits marked mitogenic and metastatic properties, whereas the progesterone metabolites, 4-pregnen-3alpha-ol-20-one (3alphaHP) and 4-pregnen-20alpha-ol-3-one (20alphaHP), oppose these actions, prompted examination of the possible effects of these progesterone metabolites on ER concentration in MCF-7 breast cancer cells. "
10/01/2001 - "Tumorous human breast tissue readily converts progesterone to 5alpha-pregnane-3,20-dione (5alphaP), and this metabolite has been shown to stimulate proliferation and to decrease adhesion of MCF-7 breast cancer cells. "
06/16/2000 - "Recent observations indicate that the progesterone metabolite, 5alpha-pregnane-3,20-dione (5alphaP), which is produced at higher levels in tumorous breast tissue, promotes cell proliferation and detachment, whereas 3alpha-hydroxy-4-pregnen-20-one (3alphaHP), which is produced at higher levels in nontumorous breast tissue, suppresses proliferation and detachment of MCF-7 breast cancer cells. "
06/16/2000 - "Plasma membrane receptors for the cancer-regulating progesterone metabolites, 5alpha-pregnane-3,20-dione and 3alpha-hydroxy-4-pregnen-20-one in MCF-7 breast cancer cells."
11/01/2005 - "Membrane 5alpha-pregnane-3,20-dione (5alphaP) receptors in MCF-7 and MCF-10A breast cancer cells are up-regulated by estradiol and 5alphaP and down-regulated by the progesterone metabolites, 3alpha-dihydroprogesterone and 20alpha-dihydroprogesterone, with associated changes in cell proliferation and detachment."
4. Neoplasms (Cancer)
5. Pregnancy-Induced Hypertension (Hypertension, Pregnancy Induced)

Related Drugs and Biologics

1. Pregnanolone (Allopregnanolone)
2. Pregnenolone
3. pregnenolone sulfate
4. Progesterone
5. Nitric Oxide Synthase (NO Synthase)
6. Neurotransmitter Agents (Neurotransmitter)
7. Antisense Oligonucleotides
8. Mifepristone (RU 486)
9. GABA-A Receptors (GABA(A) Receptor)
10. Pregnanes