Inorganic Pyrophosphatase (Pyrophosphatase, Inorganic)

An enzyme which catalyzes the hydrolysis of diphosphate (DIPHOSPHATES) into inorganic phosphate. The hydrolysis of pyrophosphate is coupled to the transport of HYDROGEN IONS across a membrane.

Also Known As:

Pyrophosphatase, Inorganic; H(+)-PPase; H+-Pyrophosphatase; Proton-Pumping Inorganic Pyrophosphatase; Proton-Translocating Pyrophosphatase; Pyrophosphate-Energized Inorganic Pyrophosphatase; H+ Pyrophosphatase; Inorganic Pyrophosphatase, Proton-Pumping; Inorganic Pyrophosphatase, Pyrophosphate-Energized; Proton Pumping Inorganic Pyrophosphatase; Proton Translocating Pyrophosphatase; Pyrophosphatase, Proton-Pumping Inorganic; Pyrophosphatase, Proton-Translocating; Pyrophosphatase, Pyrophosphate-Energized Inorganic; Pyrophosphate Energized Inorganic Pyrophosphatase

Networked: 63 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Alston, Charlotte L: 2 articles (12/2021 - 01/2016)
2.	Doudney, Kit: 2 articles (12/2021 - 01/2016)
3.	George, Peter M: 2 articles (12/2021 - 01/2016)
4.	Mayr, Johannes A: 2 articles (12/2021 - 01/2016)
5.	McFarland, Robert: 2 articles (12/2021 - 01/2016)
6.	Taylor, Robert W: 2 articles (12/2021 - 01/2016)
7.	Niu, Haiying: 2 articles (01/2021 - 09/2017)
8.	Wang, Hui: 2 articles (01/2021 - 09/2019)
9.	Luo, Dehong: 2 articles (09/2019 - 04/2018)
10.	Shen, Wenzhi: 2 articles (09/2019 - 09/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Crystallographic and modeling study of the human inorganic pyrophosphatase 1: A potential anti-cancer drug target." 01/01/2023 - "Inorganic pyrophosphatase 1 (PPA1) plays an imperative role in the advancement of malignant tumors, but its function in CRC is ill-defined. " 09/24/2019 - "Inorganic pyrophosphatase (PPA1) promotes tumor progression in several tumor types. " 04/01/2018 - "In different types of cancer in humans, inorganic pyrophosphatase (PPA1) is deregulated, thereby contributing to tumorigenesis by supplying the tumor with an enormous energy source. " 01/01/2022 - "Inorganic pyrophosphatase (PPA1) encoded by PPA1 gene belongs to Soluble Pyrophosphatases (PPase) family and is expressed widely in various tissues of Homo sapiens, as well as significantly in a variety of malignancies. "
2.	Starvation 01/01/1967 - "[Study of inorganic pyrophosphatase activity in rabbit brain in the normal state and in starvation]." 02/01/2011 - "The Arabidopsis thaliana phosphate starvation responsive gene AtPPsPase1 encodes a novel type of inorganic pyrophosphatase." 01/01/2018 - "jejuni, immunoreactivity was found for GroEL and DnaK, structural proteins (MOMP), key enzymatic proteins necessary for the microbial proliferation (adenylate kinase, enolase, inorganic pyrophosphatase and aspartate ammonia-lyase), and antioxidant enzymes (alkyl hydroperoxide reductase-AhpC and DNA protection during starvation protein - DNA protection factor against Fe2+-mediated oxidative stress). "
3.	Hypoxia (Hypoxemia) 01/01/2010 - "Quantitative PCR analysis showed that one vacuolar H(+)-pyrophosphatase (OVP3) was induced by anoxia, particularly in flood-tolerant rice. " 01/01/2010 - "Expression of vacuolar H+-pyrophosphatase (OVP3) is under control of an anoxia-inducible promoter in rice." 06/01/1995 - "The present study was undertaken to determine whether vacuolar H(+)-pyrophosphatase (V-PPase) might replace vacuolar H(+)-ATPase under energy stress due to anoxia or chilling in anoxia-tolerant species such as rice (Oryza sativa L.) and corn (Zea mays L.). " 12/01/2005 - "The effects of exogenous polyamines on the growth, polyamines contents, the activities of H(+)-ATPase and H(+)-PPase of plasma membrane and tonoplast in cucumber seedling roots under root-zone hypoxia stress were studied under hydroponic culture. " 12/01/2005 - "[Effects of exogenous polyamines on the growth and activities of H+-ATPase and H+-PPase in cucumber seedling roots under hypoxia stress]."
4.	Iron Deficiencies 02/01/2021 - "Our previous study showed that sweet potato H+-pyrophosphatase (IbVP1) plays a vital role in mitigating iron deficiency and positively controls fibrous root growth. "
5.	Cardiac Sudden Death (Sudden Cardiac Arrest) 01/01/2016 - "Sudden Cardiac Death Due to Deficiency of the Mitochondrial Inorganic Pyrophosphatase PPA2." 10/18/2023 - "Inorganic pyrophosphatase 2 (PPA2) deficiency is a genetic cause of sudden cardiac death, often triggered by viral infection or alcohol consumption. " 12/01/2021 - "Biallelic hypomorphic variants in PPA2, encoding the mitochondrial inorganic pyrophosphatase 2 protein, have been recently identified in individuals presenting with sudden cardiac death, occasionally triggered by alcohol intake or a viral infection. "

Related Drugs and Biologics

1.	Enzymes
2.	diphosphoric acid (pyrophosphoric acid)
3.	Phosphates (Orthophosphate)
4.	Vacuolar Proton-Translocating ATPases (V-Type ATPase)
5.	Proteins (Proteins, Gene)
6.	Proton-Translocating ATPases (ATPase, H+)
7.	Polyphosphates
8.	Adenosine Triphosphate (ATP)
9.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
10.	Triose-Phosphate Isomerase (Triosephosphate Isomerase)