|1.||Rich, Alexander: 5 articles (01/2013 - 02/2004)|
|2.||Lowenhaupt, Ky: 4 articles (01/2007 - 02/2004)|
|3.||Bacolla, Albino: 3 articles (01/2012 - 09/2006)|
|4.||Vasquez, Karen M: 3 articles (03/2011 - 02/2006)|
|5.||Wang, Guliang: 3 articles (03/2011 - 02/2006)|
|6.||Kim, Kyeong Kyu: 3 articles (01/2007 - 02/2004)|
|7.||Kim, Yang-Gyun: 3 articles (01/2007 - 02/2004)|
|8.||Vasudevaraju, P: 2 articles (04/2012 - 06/2008)|
|9.||Merghoub, Taha: 2 articles (01/2012 - 10/2011)|
|10.||Dai, Peihong: 2 articles (01/2012 - 10/2011)|
05/01/2009 - "Here we present a first human genome map of most stable Z-DNA segments obtained with A549 tumor cells. "
01/15/2013 - "We now report here that overexpression of ADAM-12 in triple-negative MDA-MB-231 breast cancer cells and breast cancer tumors is likely due to a marked loss of this Z-DNA-mediated transcriptional suppression function. "
01/01/1996 - "This study is the first to show that the Z-DNA inducing abilities of the polyamine analogues in synthetic polynucleotides in vitro correlates inversely with their effects on CDDP cytotoxicity in human tumor cells in culture."
12/26/2006 - "These results suggest that SWNTs might have the intriguing potential to modulate human telomeric DNA structures in vivo, like biologically relevant B-A and B-Z DNA transitions, which is of great interest for drug design and cancer therapy."
02/12/2003 - "2001, 8, 761] found that an ubiquitous RNA editing enzyme, adenosine deaminase 1 (ADAR1), and tumor-associated protein DML-1 specifically bind to Z-form DNA. "
|2.||Alzheimer Disease (Alzheimer's Disease)
06/01/2008 - "Recently, our laboratory discovered the presence of Z-DNA in the hippocampal region of severely affected Alzheimer's disease (AD) brain samples. "
10/14/2010 - "Alzheimer's disease amyloid beta converting left-handed Z-DNA back to right-handed B-form."
04/01/2012 - "Previous studies from our laboratory have shown that there is a conformational change in the genomic DNA of Parkinson's disease (PD) (B to altered B-DNA) and Alzheimer's disease brain (B to Z-DNA). "
|3.||Parkinson Disease (Parkinson's Disease)
|4.||Systemic Lupus Erythematosus (Libman-Sacks Disease)
05/01/1986 - "Since altered DNA conformations, such as Z-DNA, are more immunogenic, these results suggest that the induction or stabilization of Z-DNA by these drugs might be important in the pathogenesis of at least some cases of systemic lupus erythematosus."
01/01/1985 - "Potential Z-DNA-forming elements in serum DNA from human systemic lupus erythematosus."
02/01/1983 - "Naturally occurring antibodies to left-handed Z-DNA have been shown to be present in the sera of human patients with systemic lupus erythematosus (SLE). "
02/01/1983 - "Z-DNA-specific antibodies in human systemic lupus erythematosus."
10/01/1984 - "Left-handed "Z" DNA antibodies in rheumatoid arthritis and systemic lupus erythematosus."
02/10/2004 - "Evidence that vaccinia virulence factor E3L binds to Z-DNA in vivo: Implications for development of a therapy for poxvirus infection."
01/01/2012 - "The myxoma virus ortholog of vaccinia E3 (M029) lacks the N-terminal Z-DNA/RNA binding domain, which might contribute to the immunostimulating properties of myxoma virus."
10/01/2011 - "Furthermore, our results reveal that the N-terminal Z-DNA/RNA binding domain of vaccinia virulence factor E3, which is missing in the orthologous M029 protein expressed by myxoma virus, plays an inhibitory role in poxvirus sensing and innate cytokine production by murine pDCs."
01/01/2007 - "Notably the Z alpha domain of vaccinia E3L acquires ability to convert B-DNA to Z-DNA by mutating amino acid residues in this region. "
01/01/2012 - "Using vaccinia gene deletion mutants, we show that the Z-DNA/RNA binding domain at the N-terminus of the vaccinia immunomodulatory E3 protein is an antagonist of the innate immune response of human pDCs to poxvirus infection and TLR agonists. "
|1.||DNA (Deoxyribonucleic Acid)
|4.||RNA (Ribonucleic Acid)
|5.||Immunoglobulin G (IgG)
|6.||Carrier Proteins (Binding Protein)
|7.||Double-Stranded RNA (RNA, Double Stranded)