Carboxypeptidase H (Carboxypeptidase E)

A ZINC-containing exopeptidase primarily found in SECRETORY VESICLES of endocrine and neuroendocrine cells. It catalyzes the cleavage of C-terminal ARGININE or LYSINE residues from polypeptides and is active in processing precursors of PEPTIDE HORMONES and other bioactive peptides.

Also Known As:

Carboxypeptidase E; Enkephalin Convertase; Enkephalin-Forming Carboxypeptidase; Enkephalin-Synthesizing Carboxypeptidase; Carboxypeptidase, Enkephalin-Forming; Carboxypeptidase, Enkephalin-Synthesizing; Convertase, Enkephalin; Enkephalin Forming Carboxypeptidase; Enkephalin Synthesizing Carboxypeptidase

Networked: 107 relevant articles (1 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957

Experts

1.	Loh, Y Peng: 16 articles (03/2022 - 12/2005)
2.	Cawley, Niamh X: 7 articles (03/2019 - 12/2005)
3.	Murthy, Saravana R K: 6 articles (01/2020 - 11/2010)
4.	Lou, Hong: 5 articles (01/2021 - 03/2011)
5.	Pacak, Karel: 5 articles (01/2020 - 11/2010)
6.	Yang, Xuyu: 4 articles (03/2022 - 07/2016)
7.	Gengin, M T: 4 articles (09/2009 - 01/2000)
8.	Sun, Jing: 3 articles (01/2020 - 06/2015)
9.	Wang, Hongyue: 3 articles (01/2020 - 06/2015)
10.	Zhang, Guirong: 3 articles (01/2020 - 06/2015)

Related Diseases

1.	Adenocarcinoma 01/01/2022 - "This study evaluates the efficacy of carboxypeptidase E (CPE) mRNA including its splice isoforms, CPE-ΔN, as a biomarker for predicting recurrence in adenocarcinoma patients. "
2.	Neoplasms (Cancer) 12/01/2013 - "Carboxypeptidase E promotes cancer cell survival, but inhibits migration and invasion." 04/01/2012 - "New roles of carboxypeptidase E in endocrine and neural function and cancer." 01/01/2021 - "Previous studies have indicated that carboxypeptidase E (CPE) plays a role in promoting tumorigenesis in many cancer types. " 01/01/2021 - "Previous studies have indicated that carboxypeptidase E (CPE) plays a role in promoting tumorigenesis in many cancer types. " 11/01/2022 - "Here we review the role of the carboxypeptidase E (CPE) gene which has been shown to be important in driving growth, survival and metastasis in many cancer types. "
3.	Carcinogenesis 01/01/2021 - "Previous studies have indicated that carboxypeptidase E (CPE) plays a role in promoting tumorigenesis in many cancer types. " 01/01/2021 - "Previous studies have indicated that carboxypeptidase E (CPE) plays a role in promoting tumorigenesis in many cancer types. " 01/01/2016 - "Elevated carboxypeptidase E (CPE) levels play crucial roles in tumorigenesis and metastasis. "
4.	Neoplasm Metastasis (Metastasis) 12/01/2016 - "The current study aimed to evaluate the potential of N-terminal truncated carboxypeptidase E (CPEΔN) to predict the recurrence and metastasis of lung adenocarcinoma. " 11/01/2022 - "Here we review the role of the carboxypeptidase E (CPE) gene which has been shown to be important in driving growth, survival and metastasis in many cancer types. " 11/01/2022 - "Carboxypeptidase E and its splice variants: Key regulators of growth and metastasis in multiple cancer types." 01/01/2019 - "Carboxypeptidase E (CPE) is known to be highly expressed in some cancer types, and its N-terminal truncated form, CPE-ΔN, is implicated in tumor metastasis and poor prognosis. " 01/01/2016 - "Silencing of carboxypeptidase E inhibits cell proliferation, tumorigenicity, and metastasis of osteosarcoma cells."
5.	Ischemia 01/01/2022 - "To observe the effect of carboxypeptidase E (CPE) on the ischemia and hypoxia (I/H) injury of primary cardiomyocytes. " 12/01/2001 - "The ischemia-induced changes in carboxypeptidase E expression suggest that this enzyme may play a role in modulating the brain's response to ischemia." 02/01/2009 - "Pro-protein convertase-2/carboxypeptidase-E mediated neuropeptide processing of RGC-5 cell after in vitro ischemia." 01/01/2009 - "Pro-protein convertase-2/carboxypeptidase-E mediated neuropeptide processing of RGC-5 cell after in vitro ischemia." 12/01/2001 - "After 15 minutes of transient global ischemia followed by 8 hours of reperfusion, increased levels of carboxypeptidase E messenger RNA and protein were observed in the hippocampal CA1 and CA3 regions and in the cortex, as detected by Northern and Western blot analyses and in situ hybridization. "

Related Drugs and Biologics

1.	Protein Isoforms (Isoforms)
2.	Biomarkers (Surrogate Marker)
3.	Messenger RNA (mRNA)
4.	Enzymes
5.	Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)
6.	Neuropeptides
7.	Opioid Analgesics (Opioids)
8.	delta Opioid Receptors (delta Opioid Receptor)
9.	Methionine Enkephalin
10.	proenkephalin

Related Therapies and Procedures

1.	Pneumonectomy (Lung Volume Reduction)
2.	Aftercare (After-Treatment)
3.	Adrenalectomy