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Carboxypeptidases A (Carboxypeptidase A)

Carboxypeptidases that are primarily found the DIGESTIVE SYSTEM that catalyze the release of C-terminal amino acids. Carboxypeptidases A have little or no activity for hydrolysis of C-terminal ASPARTIC ACID; GLUTAMIC ACID; ARGININE; LYSINE; or PROLINE. This enzyme requires ZINC as a cofactor and was formerly listed as EC 3.4.2.1 and EC 3.4.12.2.
Also Known As:
Carboxypeptidase A; Carboxypeptidase A2; Carboxypeptidase A1; Carboxypeptidase A5; PCPA1 Enzyme; PCPA2 Enzyme; Procarboxypeptidase A; Procarboxypeptidase A1; Procarboxypeptidase A2
Networked: 49 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Masamune, Atsushi: 3 articles (10/2015 - 10/2013)
2. Ludwig, Maren: 2 articles (10/2015 - 10/2013)
3. Kakuta, Yoichi: 2 articles (10/2015 - 10/2013)
4. Kume, Kiyoshi: 2 articles (10/2015 - 10/2013)
5. Witt, Heiko: 2 articles (10/2015 - 10/2013)
6. Nakano, Eriko: 2 articles (10/2015 - 10/2013)
7. Shimosegawa, Tooru: 2 articles (10/2015 - 10/2013)
8. Braun, Markus: 2 articles (10/2015 - 10/2013)
9. Sahin-Tóth, Miklós: 2 articles (10/2015 - 10/2013)
10. Paliwal, Sumit: 2 articles (12/2014 - 10/2013)

Related Diseases

1. Neoplasms (Cancer)
2. Pancreatic Neoplasms (Pancreatic Cancer)
04/01/1991 - "When the reactivity of IgG in sera with the purified carboxypeptidase A was measured, the detection rates for lung, ovary, larynx, uterus, and liver cancer were more than 50%, while the rates for stomach and breast cancer were around 30%, and pancreatic cancer, benign diseases, and normal controls were minimally detected."
05/01/2012 - "To determine the serum levels of procarboxypeptidase A (pro-CPA) and carboxypeptidase A (CPA) in patients with acute and chronic pancreatitis and pancreatic cancer. "
07/01/2014 - "An abstract presented in ASCO 2014 by Orlowski et al. introduced the potential use of an elevated serum procarboxypeptidase A (PCPA) and high ratios of PCPA to free carboxypeptidase A (FCPA) in enhancing the diagnostic efficacy of pancreatic cancer either alone or with CA19-9 (Abstract #4118). "
03/01/2008 - "We profiled 18 pancreatic cancer cases and 19 controls and 19 ovarian cancer cases and 20 controls for the following proteins: a disintegrin and metalloprotease 8, CA-125, CA 19-9, carboxypeptidase A1, carcinoembryonic antigen, connective tissue growth factor, epidermal growth factor receptor, epithelial cell adhesion molecule, Her2, galectin-1, insulin-like growth factor 2, interleukin-1alpha, interleukin-7, mesothelin, macrophage migration inhibitory factor, osteopontin, secretory leukocyte peptidase inhibitor, tumor necrosis factor alpha, vascular endothelial growth factor, and chitinase 3-like 1. Probes for CA-125 were present in 3 of the multiplex panels. "
3. Reperfusion Injury
4. Cystic Fibrosis (Mucoviscidosis)
5. Flushing

Related Drugs and Biologics

1. Carboxypeptidases A (Carboxypeptidase A)
2. Phenylalanine (L-Phenylalanine)
3. FCPA
4. Trypsin
5. Enzymes
6. Serine Proteases (Serine Protease)
7. Ethylene Glycol (Monoethylene Glycol)
8. Chymotrypsin
9. CD13 Antigens (Alanine Aminopeptidase)
10. Insulin-Like Growth Factor I (IGF-1)