|1.||Mizutani, Shigehiko: 11 articles (11/2013 - 11/2002)|
|2.||Llorens-Cortes, Catherine: 7 articles (08/2014 - 05/2004)|
|3.||Mizutani, S: 5 articles (03/2015 - 01/2000)|
|4.||Marc, Yannick: 5 articles (08/2014 - 05/2008)|
|5.||Larrinaga, Gorka: 5 articles (01/2014 - 02/2007)|
|6.||Nomura, Seiji: 5 articles (09/2008 - 11/2002)|
|7.||Ramírez-Expósito, María Jesús: 4 articles (09/2014 - 10/2011)|
|8.||López, José I: 4 articles (01/2014 - 02/2007)|
|9.||Perez, Itxaro: 4 articles (01/2014 - 11/2011)|
|10.||Sanz, Begoña: 4 articles (01/2014 - 11/2011)|
03/01/1996 - "In conclusion this study demonstrates for the first time that increased villous trophoblastic angiotensinase A activity indicates an increased likelihood of the presence of pre-eclampsia and the severity of hypertensive disorders in pregnancy."
03/01/1996 - "Enhanced villous trophoblastic angiotensinase A activity was significantly associated with an increased frequency of pre-eclampsia in pregnant women (cumulative odds ratio x 0(1) 6.37; P < 0.001) and showed significant correlations with the severity of gestational hypertensive disorders, represented by systolic (r = 0.31; P < 0.05) and diastolic (r = 0.34; P < 0.05 blood pressure and by concomitant proteinuria (r = 044; P < 0.01). "
03/01/1996 - "Histochemical evaluation of placental angiotensinase A in pre-eclampsia: enzyme activity in villous trophoblast indicates an enhanced likelihood of gestational proteinuric hypertension."
01/01/1987 - "Serum aminopeptidase A (AAP) activity was measured in normal pregnancy and pre-eclampsia. "
01/01/1987 - "Serum aminopeptidase A (AAP) in normal pregnancy and pregnancy complicated by pre-eclampsia."
|2.||Premature Obstetric Labor (Premature Labor)
11/01/2013 - "The authors conclude that both aminopeptidase A and placental leucine aminopeptidase could be potentially safe and effective drugs for patients and their babies in the treatment of preeclampsia and preterm labor."
01/01/2011 - "Placental leucine aminopeptidase- and aminopeptidase A- deficient mice offer insight concerning the mechanisms underlying preterm labor and preeclampsia."
03/01/2015 - " changes of the balance between fetal angiotensin II (A-II) and vasopressin (AVP) andA-II and AVP degrading enzymes, between aminopeptidase A (APA) and placental leucine aminopeptidase( P-LAP) - in the placenta and maternal blood due to fetal stress such as hypoxia - are the provable causes of preeclampsia or preterm labor.Induction"
|3.||Hypertension (High Blood Pressure)
06/01/2005 - "Association study: the aminopeptidase a gene and essential hypertension."
08/01/2014 - "A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors."
01/01/2014 - "Here we review new insights into the predominant role of brain Ang III in the control of BP, underlining the fact that brain aminopeptidase A (APA), the enzyme generating brain Ang III, may therefore be an interesting candidate target for the treatment of hypertension. "
01/01/2014 - "[Orally active aminopeptidase A inhibitors reduce blood pressure: a new strategy for treating hypertension]."
08/30/2013 - "Structural insights into central hypertension regulation by human aminopeptidase A."
11/12/2010 - "Aminopeptidase A (APA; EC 184.108.40.206) is a transmembrane metalloprotease with several functions in tumor angiogenesis. "
07/01/2010 - "Here we exploited a peptide ligand of aminopeptidase A (APA), discovered by phage display technology for delivery of liposomal DXR to perivascular tumor cells. "
02/01/2004 - "We show that a membrane-associated protease, aminopeptidase A (APA), is upregulated and enzymatically active in blood vessels of human tumors. "
02/01/2007 - "Aminopeptidase B activity of the particulate fraction in tumors decreases (t = 2,399 vs. n = 13,536 UP/mg protein; P < 0.001) compared with nontumor tissues, and aspartyl-aminopeptidase activity decreases significantly in CCRCC (t = 137 vs. n = 223 UP/mg protein; P < 0.05). "
10/01/1978 - "When cultured mouse fibroblast strain C3H2K and rat fibroblast strain 3Y1 cells were transformed by SV40 or by a ts A mutant and maintained at permissive temperature, aminopeptidase A activity was drastically decreased, and the ratio of aminopeptidase A to aminopeptidase B was reduced to the levels of tumor cells. "
|5.||Breast Neoplasms (Breast Cancer)
10/01/2011 - "We observed an increase in aminopeptidase N (APN) and aminopeptidase B (APB) activities in women with breast cancer; however, a decrease in aspartyl-aminopeptidase (AspAP) activity in premenopausal women. "
03/01/2006 - "Aminopeptidase N (APN), aminopeptidase B (APB) and aminopeptidase A (aspartyl- and glutamyl-aminopeptidase, APA) activities are measured in the pineal gland of rats with breast cancer induced by N-methyl nitrosourea (NMU). "
05/01/2012 - "The aim of this study was to investigate the putative changes in serum angiotensinase activities (aminopeptidase N, APN; aminopeptidase B, APB; aminopeptidase A, APA; aspartyl aminopeptidase, ASAP) involved in the renin-angiotensin system (RAS) in women with breast cancer treated or not with a neoadjuvant therapy of paclitaxel and anthracycline and in healthy women volunteers. "
|2.||CD13 Antigens (Alanine Aminopeptidase)
|4.||Glutamyl Aminopeptidase (Aspartyl Aminopeptidase)
|2.||Surgical Instruments (Clip)