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alpha-Mannosidase (LAMAN)

An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.
Also Known As:
LAMAN; alpha-D-Mannosidase; Neutral alpha-Mannosidase; alpha Mannosidase B; alpha-D-Mannoside Mannohydrolase; Lysosomal alpha Mannosidase; Mannohydrolase, alpha-D-Mannoside; Mannosidase B, alpha; Neutral alpha Mannosidase; alpha D Mannosidase; alpha D Mannoside Mannohydrolase; alpha Mannosidase; alpha-Mannosidase, Lysosomal; alpha-Mannosidase, Neutral; Lysosomal alpha-Mannosidase
Networked: 248 relevant articles (4 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Fogh, Jens: 5 articles (01/2015 - 09/2004)
2. Saftig, Paul: 5 articles (01/2013 - 09/2004)
3. Hopwood, J J: 5 articles (01/2008 - 05/2001)
4. Zwierz, Krzysztof: 4 articles (08/2009 - 05/2006)
5. Beccari, T: 4 articles (06/2009 - 12/2000)
6. Liu, Yin: 4 articles (12/2008 - 12/2003)
7. Nilssen, Øivind: 3 articles (01/2015 - 07/2004)
8. Malm, Dag: 3 articles (01/2013 - 04/2004)
9. Andersson, Claes: 3 articles (01/2010 - 09/2004)
10. D'Hooge, Rudi: 3 articles (11/2008 - 07/2005)

Related Diseases

1. alpha-Mannosidosis
2. Herpes Zoster
3. Gingivitis
4. Mannosidase Deficiency Diseases (Mannosidosis)
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Glycoproteins (Glycoprotein)
2. beta-Mannosidase
3. Hexosaminidase A (Hex A)
4. Glucuronidase
5. beta-Galactosidase (Lactaid)
6. alpha-L-Fucosidase (Fucosidase)
7. Enzymes
8. beta-N-Acetylhexosaminidases
9. Acid Phosphatase
10. Swainsonine

Related Therapies and Procedures

1. Enzyme Replacement Therapy
2. Aftercare (After-Treatment)
3. Sutures (Suture)