|1.||Fogh, Jens: 5 articles (01/2015 - 09/2004)|
|2.||Saftig, Paul: 5 articles (01/2013 - 09/2004)|
|3.||Hopwood, J J: 5 articles (01/2008 - 05/2001)|
|4.||Zwierz, Krzysztof: 4 articles (08/2009 - 05/2006)|
|5.||Beccari, T: 4 articles (06/2009 - 12/2000)|
|6.||Liu, Yin: 4 articles (12/2008 - 12/2003)|
|7.||Nilssen, Øivind: 3 articles (01/2015 - 07/2004)|
|8.||Malm, Dag: 3 articles (01/2013 - 04/2004)|
|9.||Andersson, Claes: 3 articles (01/2010 - 09/2004)|
|10.||D'Hooge, Rudi: 3 articles (11/2008 - 07/2005)|
04/01/1992 - "Comparison with the standard leukocyte alpha-mannosidase assay showed this serum or plasma assay to be equally effective in diagnosing alpha-mannosidosis."
03/16/2002 - "The R227W allele segregated with the alpha-mannosidosis genotype in the guinea pig colony and introduction of R227W into the wild-type sequence eliminated the production of recombinant alpha-mannosidase activity in heterologous expression studies. "
01/01/2009 - "A comprehensive homology modeling study of all the wild-type and inherited mutations of lysosomal alpha-mannosidase in four different species, human, cow, cat and guinea pig, reveals a significant correlation between the severity of the genotype and the phenotype in alpha-mannosidosis. "
01/01/2015 - "Alpha-mannosidosis is caused by mutations in MAN2B1, leading to loss of lysosomal alpha-mannosidase activity. "
09/01/2014 - "Alpha-mannosidosis (OMIM 248500) is a rare, autosomal recessive, multisystemic, progressive lysosomal storage disorder caused by a deficiency of alpha-mannosidase. "
|4.||Mannosidase Deficiency Diseases (Mannosidosis)
03/01/1988 - "Immunoprecipitation studies using antibody specific for the lymphocyte type of lysosomal alpha-D-mannosidase confirmed that the increased activity in the cocultured mannosidosis cells resulted from the acquisition of the lymphocyte enzyme. "
01/01/1983 - "In a previous study, we compared the alpha-mannosidase from mannosidosis tissues to that from normal one and we characterized the mutant. "
05/01/1980 - "The prenatal diagnosis of affected fetuses in two families at risk for mannosidosis gave us the opportunity to study the residual alpha-mannosidase activity. "
04/01/2009 - "Mannosidosis is an extremely rare genetic disease occurring due to deficiency of the lysosomal enzyme, alpha-mannosidase. "
08/01/2006 - "A murine mannosidosis model, LAMAN-deficient mice, was examined on a behavioral task battery that included test for neuromotor, exploratory and neurocognitive (spatial learning and memory) abilities, and multivariate statistical analyses were used to identify behavioral and neurocognitive domains that are most heavily affected by LAMAN deficiency. "
01/01/2010 - "Studies toward new anti-cancer strategies based on alpha-mannosidase inhibition."
01/10/2004 - "In our study, the effect of 6A8 alpha-mannosidase (MAN 6A8), recently discovered in our laboratory, on malignant behaviors of tumor cells was examined. "
08/01/2007 - "To study the effect of human alpha-mannosidase Man2c1 transgene on tumor growth and metastasis in mice. "
08/01/2007 - "[Effects of human alpha-mannosidase Man2c1 transgene on growth and metastasis of transplanted tumor in mice]."
04/01/2010 - "Methods for performing the assay using several concentrations of the known alpha-mannosidase inhibitor swainsonine are also presented, demonstrating a potential for use of the assay as a simple method for high-throughput screening of inhibitors potentially useful in cancer treatment."
|3.||Hexosaminidase A (Hex A)
|1.||Enzyme Replacement Therapy