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alpha-Mannosidase (LAMAN)

An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.
Also Known As:
LAMAN; alpha-D-Mannosidase; Neutral alpha-Mannosidase; alpha Mannosidase B; alpha-D-Mannoside Mannohydrolase; Lysosomal alpha Mannosidase; Mannohydrolase, alpha-D-Mannoside; Mannosidase B, alpha; Neutral alpha Mannosidase; alpha D Mannosidase; alpha D Mannoside Mannohydrolase; alpha Mannosidase; alpha-Mannosidase, Lysosomal; alpha-Mannosidase, Neutral; Lysosomal alpha-Mannosidase
Networked: 293 relevant articles (5 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Fogh, Jens: 8 articles (11/2018 - 09/2004)
2. Saftig, Paul: 7 articles (10/2017 - 09/2004)
3. Borgwardt, Line: 6 articles (06/2020 - 09/2014)
4. Andersson, Claes: 5 articles (10/2017 - 09/2004)
5. D'Hooge, Rudi: 5 articles (10/2017 - 07/2005)
6. Liu, Yin: 5 articles (12/2008 - 12/2003)
7. Hopwood, J J: 5 articles (01/2008 - 05/2001)
8. Cattaneo, Federica: 4 articles (06/2020 - 01/2018)
9. Guffon, Nathalie: 4 articles (06/2020 - 01/2018)
10. Lüllmann-Rauch, Renate: 4 articles (11/2015 - 09/2004)

Related Diseases

1. alpha-Mannosidosis
2. Herpes Zoster
3. Gingivitis
4. Mannosidase Deficiency Diseases (Mannosidosis)
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Glycoproteins (Glycoprotein)
2. beta-Mannosidase
3. Ligands
4. Hexosaminidase A (Hex A)
5. beta-Galactosidase (Lactaid)
6. Glucuronidase
7. Enzymes
8. alpha-L-Fucosidase (Fucosidase)
9. Swainsonine
10. beta-N-Acetylhexosaminidases

Related Therapies and Procedures

1. Enzyme Replacement Therapy
2. Aftercare (After-Treatment)
3. Intravenous Administration
4. Sutures (Suture)