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Phosphatidylinositol Diacylglycerol-Lyase

A phosphorus-oxygen lyase found primarily in BACTERIA. The enzyme catalyzes the cleavage of a phosphoester linkage in 1-phosphatidyl-1D-myo-inositol to form 1D-myo-inositol 1,2-cyclic phosphate and diacylglycerol. The enzyme was formerly classified as a phosphoric diester hydrolase (EC 3.1.4.10) and is often referred to as a TYPE C PHOSPHOLIPASES. However it is now known that a cyclic phosphate is the final product of this enzyme and that water does not enter into the reaction.
Also Known As:
Monophosphatidylinositol Phosphodiesterase; 1 Phosphatidylinositol Phosphodiesterase; Diacylglycerol-Lyase, Phosphatidylinositol; Phosphatidylinositol Diacylglycerol Lyase; Phosphodiesterase, 1-Phosphatidylinositol; Phosphodiesterase, Monophosphatidylinositol; 1-Phosphatidylinositol Phosphodiesterase
Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Kreiswirth, Barry N: 1 article (05/2007)
2. McGavin, Martin J: 1 article (05/2007)
3. Deleo, Frank R: 1 article (05/2007)
4. Hammer, Carl H: 1 article (05/2007)
5. Whitney, Adeline R: 1 article (05/2007)
6. Burlak, Christopher: 1 article (05/2007)
7. Robinson, Mary-Ann: 1 article (05/2007)

Related Diseases

1. Infection

Related Drugs and Biologics

1. Virulence Factors (Pathogenicity Factors)
2. N-Acetylmuramoyl-L-alanine Amidase (Autolysin)
3. Ferritins (Ferritin)
4. Antibodies