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Phosphodiesterase I (5' Exonuclease)

A phosphoric diester hydrolase that removes 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated OLIGONUCLEOTIDES. It has low activity towards POLYNUCLEOTIDES and the presence of 3'-phosphate terminus on the substrate may inhibit hydrolysis.
Also Known As:
5' Exonuclease; 5'-Exonuclease; 5'-Nucleotidephosphodiesterase; Alkaline Phosphodiesterase; Alkaline Phosphodiesterase I; Oligonucleate 5'-Nucleotidohydrolase; Orthophosphoric Diester Phosphohydrolase; 5' Nucleotidephosphodiesterase; Diester Phosphohydrolase, Orthophosphoric; Oligonucleate 5' Nucleotidohydrolase; Phosphodiesterase I, Alkaline; Phosphodiesterase, Alkaline; Phosphohydrolase, Orthophosphoric Diester
Networked: 48 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Posadas-Romero, Carlos: 4 articles (02/2015 - 01/2012)
2. Vargas-Alarcón, Gilberto: 4 articles (02/2015 - 01/2012)
3. Medina-Urrutia, Aida: 3 articles (02/2015 - 01/2013)
4. Villarreal-Molina, Teresa: 3 articles (02/2015 - 01/2013)
5. Pérez-Hernández, Nonanzit: 2 articles (02/2015 - 01/2012)
6. Cardoso-Saldaña, Guillermo: 2 articles (02/2015 - 09/2014)
7. Posadas-Sánchez, Rosalinda: 2 articles (02/2015 - 01/2013)
8. Rodríguez-Pérez, José Manuel: 2 articles (02/2015 - 01/2012)
9. Alvarez-León, Edith: 2 articles (09/2014 - 01/2013)
10. Kimura-Hayama, Eric: 2 articles (09/2014 - 01/2013)

Related Diseases

1. Infection
2. Leukemia
3. Fatty Liver
4. Coronary Artery Disease (Coronary Atherosclerosis)
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. DNA (Deoxyribonucleic Acid)
2. PPAR alpha
3. Lipoproteins (Lipoprotein)
4. DNA Polymerase II
5. fludarabine monophosphate (Fludara)
6. 5'-Nucleotidase (5' Nucleotidase)
7. nucleotide pyrophosphatase
8. Hormones
9. Adenosine Triphosphatases (ATPase)
10. Messenger RNA (mRNA)

Related Therapies and Procedures

1. Ligation