11-beta-Hydroxysteroid Dehydrogenase Type 1

Subscribe to Selected New Research on 11-beta-Hydroxysteroid Dehydrogenase Type 1

182 relevant articles (10 outcomes, 17 trials/studies) found for this Bio-Agent

Description: A low-affinity 11 beta-hydroxysteroid dehydrogenase found in a variety of tissues, most notably in LIVER; LUNG; ADIPOSE TISSUE; vascular tissue; OVARY; and the CENTRAL NERVOUS SYSTEM. The enzyme acts reversibly and can use either NAD or NADP as cofactors.

Also Known As:

11 beta-Hydroxysteroid Dehydrogenase Type 1; 11beta-HSD1; 11beta-HSD1 Reductase; 11beta-Hydroxysteroid Dehydrogenase Type 1; 11beta HSD1 Reductase; 11beta Hydroxysteroid Dehydrogenase Type 1

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1

Enzymes: 24340

Oxidoreductases: 6825

Alcohol Oxidoreductases

Hydroxysteroid Dehydrogenases: 6

11-beta-Hydroxysteroid Dehydrogenases: 219

11-beta-Hydroxysteroid Dehydrogenase Type 1: 182

human HSD11B1 protein

Experts

1.	Walker, Brian R: 11 articles (04/2008 - 07/2003)
2.	Stewart, Paul M: 7 articles (10/2008 - 04/2002)
3.	Seckl, Jonathan R: 7 articles (04/2008 - 07/2003)
4.	Tomlinson, Jeremy W: 5 articles (10/2008 - 04/2002)
5.	Morton, Nicholas M: 4 articles (01/2008 - 05/2004)
6.	Walker, B R: 4 articles (09/2007 - 01/2000)
7.	Wake, Deborah J: 4 articles (09/2006 - 08/2003)
8.	Stewart, P M: 3 articles (09/2004 - 12/2002)
9.	Masuzaki, Hiroaki: 2 articles (12/2006 - 12/2003)
10.	Andrew, Ruth: 2 articles (11/2006 - 03/2005)

Related Diseases

1.	Syndrome 12/01/2005 - "Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome." 03/26/2008 - "In this study, we examined the effects of multiple humoral factors related to the metabolic syndrome on the transcriptional activity of 11beta-HSD1 gene in hepatocytes in vitro" 09/01/2008 - "Up-regulation of 11beta-HSD1 in adipose tissue and liver is of pathogenic importance in metabolic syndrome" 08/01/2008 - "Thus, 11 beta-hydroxysteroid dehydrogenase type 1 is a promising drug target for treating the metabolic syndrome and type 2 diabetes" 07/24/2008 - "Evidence suggests that selective inhibition of 11beta-HSD1 could treat diabetes and metabolic syndrome" Get all the results and reference details, order at left...
2.	Body Weight (Weight, Body) 06/01/2003 - "We observed an inverse relationship between hepatic 11beta-HSD1 expression and body weight in ob/ob mice and lean littermates" 04/01/2008 - "The reduced body weight and improved metabolic control in mice with high fat diet-induced obesity upon daily CBX administration highlights the potential value of selective 11beta-HSD1 inhibition as a new route for the treatment of type 2 diabetes and obesity." 09/01/2006 - "11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue and prospective changes in body weight and insulin resistance." 05/01/2007 - "Rats fed a high-sucrose, high-fat diet were treated or not with a specific 11beta-HSD1 inhibitor (compound A, 3 mg/kg.d) for 3 wk. Compound A did not alter food intake or body weight gain but specifically reduced mesenteric adipose weight (-18%) and adipocyte size, without significantly affecting those of epididymal or retroperitoneal depots" 06/01/2003 - "In addition, leptin treatment of STZ-treated ob/ob mice caused marked increases in hepatic 11beta-HSD1 levels associated with decreased body weight and a significant reduction in hyperglycemia due to pancreatic beta-cell damage" Get all the results and reference details, order at left...
3.	Obesity 05/01/2007 - "This study aimed to assess in a rat model of diet-induced obesity the effects of pharmacological 11beta-HSD1 inhibition on the morphology and expression of key genes of lipid metabolism in intraabdominal adipose depots" 01/01/2004 - "The aim of this study was to determine whether up-regulation of human adipose 11beta-HSD1 in obesity can also be found at the gene expression level" 02/01/2001 - "The main results of our study are the exclusion of a common association of 11beta-HSD1 mutations to obesity and the identification of two novel allelic variants for the gene 11beta-HSD1 in the Italian population, not previously described in any database." 06/01/2008 - "A large variety of 11beta-HSD1 inhibitor classes are under investigation by the pharmaceutical industry to treat type 2 diabetes and obesity." 05/01/2008 - "Blocking adipogenesis with a novel and specific 11beta-HSD1 inhibitor may represent a novel approach to treat obesity in patients with MS." Get all the results and reference details, order at left...
4.	Hypertension (High Blood Pressure) 09/01/1997 - "In the present study we measured the activity of hepatic and kidney 11beta-HSD1 in Dahl-S and R rats before and after the development of hypertension" 06/01/2008 - "Possible pathogenetic role of 11 beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) gene polymorphisms in arterial hypertension]" 07/01/2003 - "Taken together, our findings suggest that overexpression of 11beta-HSD1 in fat is sufficient to cause salt-sensitive hypertension mediated by an activated RAS" 11/01/2004 - "11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) is a candidate gene for hypertension, diabetes, and obesity through altered glucocorticoid production" 03/01/2008 - "More recently, the pathophysiological role of 11beta-HSD1 has been explored and studies suggest that increased 11beta-HSD1 activity within target tissues may promote insulin resistance, obesity, hypertension and dyslipidemia" Get all the results and reference details, order at left...
5.	Metabolic Diseases (Metabolic Disease) 09/01/2006 - "Taken together, it appears that inhibitors against 11beta-HSD1 constitute a promising avenue for novel treatment strategies against the underlying causes of cardiovascular and other metabolic diseases." 09/01/2007 - "Trials in humans though will be the ultimate test to determine if inhibition of 11beta-HSD1 offers a new tool in the treatment of metabolic disease." 06/01/2004 - "Down-regulation of adipose 11beta-hydroxysteroid dehydrogenase type 1 by high-fat feeding in mice: a potential adaptive mechanism counteracting metabolic disease." 04/01/2008 - "11beta-HSD1 has been studied as a potential treatment for metabolic disease such as diabetes and obesity" 04/01/2008 - "11beta-HSD1, inflammation, metabolic disease and age-related cognitive (dys)function." Get all the results and reference details, order at left...
55 Diseases and 182 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Hydrocortisone (Cortisol)
2.	Glucocorticoids
3.	Glucose (Dextrose)
4.	Insulin (Novolin)
5.	11-beta-Hydroxysteroid Dehydrogenase Type 2 (11 beta-Hydroxysteroid Dehydrogenase Type 2)
6.	Leptin
7.	Cholesterol
8.	Triglycerides (Triacylglycerol)
9.	Sodium
10.	Hormones
63 Drugs and Important Bio-Agents and 117 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Highly Active Antiretroviral Therapy (HAART)
1 Therapies and Procedures and 1 more articles analyzed in the Research Interface, order at left...

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