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1-Alkyl-2-acetylglycerophosphocholine Esterase (PAF Acetylhydrolase)

A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.
Also Known As:
PAF Acetylhydrolase; Lipoprotein-Associated Phospholipase A(2); Lipoprotein-Associated Phospholipase A2; Lp-PLA(2); Lp-PLA2; PAF 2-Acetylhydrolase; PAF 2-Acylhydrolase; PAF Acetylhydrolase II; Platelet-activating Factor Acetylhydrolase IB; 1 Alkyl 2 acetylglycerophosphocholine Esterase; 2-Acetylhydrolase, PAF; Acetylhydrolase II, PAF; Acetylhydrolase, PAF; Esterase, 1-Alkyl-2-acetylglycerophosphocholine; Factor Hydrolase, Platelet-Activating; Hydrolase, Platelet-Activating Factor; Lipoprotein Associated Phospholipase A2; Lp PLA2; PAF 2 Acetylhydrolase; PAF 2 Acylhydrolase; Phospholipase A2, Lipoprotein-Associated; Platelet Activating Factor Hydrolase; Platelet activating Factor Acetylhydrolase IB; Platelet-Activating Factor Hydrolase
Networked: 991 relevant articles (42 outcomes, 270 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Ballantyne, Christie M: 24 articles (08/2022 - 02/2004)
2. Koenig, Wolfgang: 22 articles (01/2020 - 10/2004)
3. Tselepis, Alexandros D: 21 articles (09/2014 - 12/2002)
4. McConnell, Joseph P: 17 articles (03/2015 - 05/2004)
5. Nelson, Jeanenne J: 16 articles (01/2012 - 01/2005)
6. Lee, Jong Ho: 15 articles (01/2020 - 09/2006)
7. Cushman, Mary: 14 articles (01/2018 - 05/2008)
8. Macphee, Colin H: 12 articles (01/2022 - 06/2002)
9. Wolfert, Robert L: 12 articles (03/2014 - 01/2002)
10. Kim, Minjoo: 10 articles (01/2020 - 01/2014)

Related Diseases

1. Atherosclerosis
2. Coronary Disease (Coronary Heart Disease)
3. Stroke (Strokes)
4. Inflammation (Inflammations)
5. Cardiovascular Diseases (Cardiovascular Disease)

Related Drugs and Biologics

1. C-Reactive Protein
2. 1-Alkyl-2-acetylglycerophosphocholine Esterase (PAF Acetylhydrolase)
3. darapladib
4. oxidized low density lipoprotein
5. Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)
6. Atorvastatin (Lipitor)
7. Lipids
8. Apolipoproteins
9. LDL Cholesterol
10. Triglycerides (Triacylglycerol)

Related Therapies and Procedures

1. Therapeutics
2. Hormone Replacement Therapy (Therapy, Hormone Replacement)
3. Coronary Artery Bypass (Coronary Artery Bypass Surgery)
4. Bariatric Surgery
5. Caloric Restriction