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1-Alkyl-2-acetylglycerophosphocholine Esterase (PAF Acetylhydrolase)

A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.
Also Known As:
PAF Acetylhydrolase; Lipoprotein-Associated Phospholipase A(2); Lipoprotein-Associated Phospholipase A2; Lp-PLA(2); Lp-PLA2; PAF 2-Acetylhydrolase; PAF 2-Acylhydrolase; PAF Acetylhydrolase II; Platelet-activating Factor Acetylhydrolase IB; 1 Alkyl 2 acetylglycerophosphocholine Esterase; 2-Acetylhydrolase, PAF; Acetylhydrolase II, PAF; Acetylhydrolase, PAF; Esterase, 1-Alkyl-2-acetylglycerophosphocholine; Factor Hydrolase, Platelet-Activating; Hydrolase, Platelet-Activating Factor; Lipoprotein Associated Phospholipase A2; Lp PLA2; PAF 2 Acetylhydrolase; PAF 2 Acylhydrolase; Phospholipase A2, Lipoprotein-Associated; Platelet Activating Factor Hydrolase; Platelet activating Factor Acetylhydrolase IB; Platelet-Activating Factor Hydrolase
Networked: 595 relevant articles (19 outcomes, 142 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Tselepis, Alexandros D: 21 articles (09/2014 - 12/2002)
2. Koenig, Wolfgang: 18 articles (01/2015 - 10/2004)
3. Ballantyne, Christie M: 17 articles (08/2015 - 02/2004)
4. McConnell, Joseph P: 16 articles (03/2015 - 05/2004)
5. Nelson, Jeanenne J: 16 articles (01/2012 - 01/2005)
6. Wolfert, Robert L: 11 articles (03/2014 - 01/2002)
7. Cushman, Mary: 10 articles (07/2015 - 05/2008)
8. Macphee, Colin H: 10 articles (02/2015 - 06/2002)
9. Zalewski, Andrew: 10 articles (05/2011 - 05/2005)
10. Hoogeveen, Ron C: 8 articles (08/2015 - 02/2004)

Related Diseases

1. Stroke (Strokes)
2. Atherosclerosis
3. Coronary Disease (Coronary Heart Disease)
4. Inflammation
5. Atherosclerotic Plaque (Atheroma)

Related Drugs and Biologics

1. C-Reactive Protein
2. Lipoproteins (Lipoprotein)
3. darapladib
4. Secretory Phospholipases A2
5. Apolipoproteins
6. LDL Cholesterol
7. Triglycerides (Triacylglycerol)
8. atorvastatin (Lipitor)
9. Pravastatin (Pravachol)
10. Lysophosphatidylcholines (Lysophosphatidylcholine)

Related Therapies and Procedures

1. Bariatric Surgery
2. Caloric Restriction
3. Immunomodulation
4. Intensive Care (Surgical Intensive Care)
5. Aftercare (After-Treatment)