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Electron Transport Complex I (NADH-CoQ Reductase)

A flavoprotein and iron sulfur-containing oxidoreductase complex that catalyzes the conversion of UBIQUINONE to ubiquinol. In MITOCHONDRIA the complex also couples its reaction to the transport of PROTONS across the internal mitochondrial membrane. The NADH DEHYDROGENASE component of the complex can be isolated and is listed as EC 1.6.99.3.
Also Known As:
NADH-CoQ Reductase; NADH Dehydrogenase (Ubiquinone); NADH-Coenzyme Q Reductase; Complex I Dehydrogenase; NADH DH I; NADH Dehydrogenase Complex 1; NADH Dehydrogenase I; NADH Q1 Oxidoreductase; NADH-Ubiquinone Oxidoreductase; NADH-Ubiquinone Reductase; Respiratory Complex I; Rotenone-Sensitive Mitochondrial NADH-Ubiquinone Oxidoreductase; Ubiquinone Reductase; Dehydrogenase, Complex I; NADH CoQ Reductase; NADH Coenzyme Q Reductase; NADH Ubiquinone Oxidoreductase; NADH Ubiquinone Reductase; Oxidoreductase, NADH Q1; Oxidoreductase, NADH-Ubiquinone; Reductase, NADH-Ubiquinone; Rotenone Sensitive Mitochondrial NADH Ubiquinone Oxidoreductase
Networked: 370 relevant articles (6 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Gasparre, Giuseppe: 13 articles (01/2022 - 04/2008)
2. Porcelli, Anna Maria: 9 articles (01/2022 - 03/2010)
3. Iommarini, Luisa: 8 articles (01/2022 - 03/2013)
4. Kurelac, Ivana: 7 articles (01/2022 - 01/2013)
5. Hirst, Judy: 5 articles (01/2021 - 03/2008)
6. Carelli, Valerio: 5 articles (01/2017 - 03/2010)
7. Bai, Yidong: 4 articles (01/2022 - 05/2009)
8. De Luise, Monica: 4 articles (01/2022 - 06/2015)
9. Ghelli, Anna: 4 articles (01/2022 - 03/2010)
10. Guy, John: 4 articles (01/2022 - 01/2012)

Related Diseases

1. Mitochondrial Diseases (Mitochondrial Disease)
2. Neoplasms (Cancer)
3. Insulin Resistance
4. Stomach Neoplasms (Stomach Cancer)
5. Body Weight (Weight, Body)
12/01/2012 - "Prophylactic administration of O(3)-O(2) mixture to 3 month-old rats, at an intrarectal dose of 0.6 mg O(3) kg(-1) body weight twice/week for 3 months then once/week until the age of 15 months, normalized reduced glutathione content, adenosine triphosphate/adenosine diphosphate ratio, mitochondrial superoxide dismutase (SOD) and complex IV (cytochrome-c oxidase) activities, improved glutathione redox index (GSHRI), complex I (NADH-ubiquinone oxidoreductase) and mitochondrial nitric oxide synthase (mtNOS) activities, and attenuated the rise in malondialdehyde (MDA) and mitochondrial protein carbonyl levels. "
06/01/1983 - "It was shown that the contents of vitamin E and ubiquinone as well as the activities of succinate- and NADH-ubiquinone reductase, succinate- and NADH-dehydrogenases in liver mitochondria are increased and the levels of ATP, adenine nucleotides and phosphate potential in the livers of vitamin E-deficient rats are elevated 3 hours after alpha-tocopherol injection (5 micrograms per 1 g of body weight). "
10/01/2020 - "Abbreviations: ABC: ATP binding cassette; ACADM: acyl-CoA dehydrogenase medium chain; ACTB: actin, beta; ATG: autophagy related; AUC: area under the curve; Baf: bafilomycin A1; BAT: brown adipose tissue; BODIPY: boron-dipyrromethene; BSA: bovine serum albumin; BW: body weight; CAT: chloramphenicol acetyltransferase; CM: complete medium; CPT1A: carnitine palmitoyltransferase 1a, liver; CQ: chloroquine; CTRL: control; EGFP: enhanced green fluorescent protein; CTSD: cathepsin D; EAT: epididymal adipose tissue; EGFR: epidermal growth factor receptor; EIF4EBP1: eukaryotic translation initiation factor 4E binding protein 1; FA: fatty acid; FBS: fetal bovine serum; GTT: glucose tolerance test; HE: hematoxylin and eosin; HFD: high-fat diet; I/R: ischemia-reperfusion; ITT: insulin tolerance test; KAP: kidney androgen regulated protein; KO: knockout; LAMP1: lysosomal associated membrane protein 1; LD: lipid droplet; LRP2: low density lipoprotein receptor related protein 2; MAP1LC3B: microtubule associated protein 1 light chain 3 beta; MAT: mesenteric adipose tissue; MS: mass spectrometry; MTOR: mechanistic target of rapamycin kinase; MTORC1: MTOR complex 1; NDRG1: N-myc downstream regulated 1; NDUFB5: NADH:ubiquinone oxidoreductase subunit B5; NEFA: non-esterified fatty acid; OA: oleic acid; OCT: optimal cutting temperature; ORO: Oil Red O; PAS: Periodic-acid Schiff; PFA: paraformaldehyde; PIK3C3: phosphatidylinositol 3-kinase catalytic subunit type 3; PPARA: peroxisome proliferator activated receptor alpha; PPARGC1A: PPARG coactivator 1 alpha; PTEC: proximal tubular epithelial cell; RAB7A: RAB7A, member RAS oncogene family; RPS6: ribosomal protein S6; RPS6KB1: ribosomal protein S6 kinase B1; RT: reverse transcription; RUBCN: rubicon autophagy regulator; SAT: subcutaneous adipose tissue; SFC: supercritical fluid chromatography; SQSTM1: sequestosome 1; SREBF1: sterol regulatory element binding transcription factor 1; SV-40: simian virus-40; TFEB: transcription factor EB; TG: triglyceride; TS: tissue specific; TUNEL: terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling; UN: urea nitrogen; UQCRB: ubiquinol-cytochrome c reductase binding protein; UVRAG: UV radiation resistance associated; VPS: vacuolar protein sorting; WAT: white adipose tissue."

Related Drugs and Biologics

1. Electron Transport Complex IV (Cytochrome c Oxidase)
2. Rotenone
3. Enzymes
4. NADH Dehydrogenase
5. Adenosine Triphosphate (ATP)
6. Succinic Acid (Succinate)
7. Metformin (Glucophage)
8. Glutathione (Reduced Glutathione)
9. Mitochondrial Proteins (Mitochondrial Protein)
10. Triglycerides (Triacylglycerol)

Related Therapies and Procedures

1. Anesthesia
2. Therapeutics
3. Drug Therapy (Chemotherapy)
4. Protein-Restricted Diet (Diet, Protein Restricted)
5. Fecal Microbiota Transplantation