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Electron Transport Complex I (NADH-CoQ Reductase)

A flavoprotein and iron sulfur-containing oxidoreductase complex that catalyzes the conversion of UBIQUINONE to ubiquinol. In MITOCHONDRIA the complex also couples its reaction to the transport of PROTONS across the internal mitochondrial membrane. The NADH DEHYDROGENASE component of the complex can be isolated and is listed as EC 1.6.99.3.
Also Known As:
NADH-CoQ Reductase; NADH Dehydrogenase (Ubiquinone); NADH-Coenzyme Q Reductase; Bacterial Electron Transport Complex I; Complex I Dehydrogenase; Mitochondrial Electron Transport Complex I; NADH DH I; NADH Dehydrogenase Complex 1; NADH Dehydrogenase I; NADH Q1 Oxidoreductase; NADH-Ubiquinone Oxidoreductase; NADH-Ubiquinone Reductase; Respiratory Complex I; Rotenone-Sensitive Mitochondrial NADH-Ubiquinone Oxidoreductase; Ubiquinone Reductase; Dehydrogenase, Complex I; NADH CoQ Reductase; NADH Coenzyme Q Reductase; NADH Ubiquinone Oxidoreductase; NADH Ubiquinone Reductase; Oxidoreductase, NADH Q1; Oxidoreductase, NADH-Ubiquinone; Reductase, NADH-Ubiquinone; Rotenone Sensitive Mitochondrial NADH Ubiquinone Oxidoreductase
Networked: 203 relevant articles (4 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Gasparre, Giuseppe: 8 articles (06/2015 - 04/2008)
2. Porcelli, Anna Maria: 5 articles (06/2015 - 03/2010)
3. Iommarini, Luisa: 4 articles (06/2015 - 01/2013)
4. Kurelac, Ivana: 4 articles (06/2015 - 01/2013)
5. Carelli, Valerio: 4 articles (03/2014 - 03/2010)
6. Ceccarelli, Claudio: 4 articles (01/2013 - 03/2010)
7. Munnich, Arnold: 4 articles (04/2007 - 01/2003)
8. Lemire, Bernard D: 3 articles (09/2015 - 02/2004)
9. Calvaruso, Maria Antonietta: 3 articles (06/2014 - 01/2013)
10. Ghelli, Anna: 3 articles (03/2014 - 03/2010)

Related Diseases

1. Neoplasms (Cancer)
2. Stomach Neoplasms (Stomach Cancer)
3. Hepatitis
4. Body Weight (Weight, Body)
5. Insulin Resistance

Related Drugs and Biologics

1. Electron Transport Complex IV (Cytochrome c Oxidase)
2. Rotenone
3. Adenosine Triphosphate (ATP)
4. Succinic Acid (Succinate)
5. Glutathione (Reduced Glutathione)
6. Metformin (Glucophage)
7. Calcium-Calmodulin-Dependent Protein Kinase Kinase
8. Mitochondrial Proteins (Mitochondrial Protein)
9. Nitric Oxide Synthase (NO Synthase)
10. Superoxide Dismutase

Related Therapies and Procedures

1. Protein-Restricted Diet (Diet, Protein Restricted)
2. Drug Therapy (Chemotherapy)