|1.||Gasparre, Giuseppe: 8 articles (06/2015 - 04/2008)|
|2.||Porcelli, Anna Maria: 5 articles (06/2015 - 03/2010)|
|3.||Iommarini, Luisa: 4 articles (06/2015 - 01/2013)|
|4.||Kurelac, Ivana: 4 articles (06/2015 - 01/2013)|
|5.||Carelli, Valerio: 4 articles (03/2014 - 03/2010)|
|6.||Ceccarelli, Claudio: 4 articles (01/2013 - 03/2010)|
|7.||Munnich, Arnold: 4 articles (04/2007 - 01/2003)|
|8.||Lemire, Bernard D: 3 articles (09/2015 - 02/2004)|
|9.||Calvaruso, Maria Antonietta: 3 articles (06/2014 - 01/2013)|
|10.||Ghelli, Anna: 3 articles (03/2014 - 03/2010)|
11/01/2008 - "Mechanistic studies indicate that furospongolide inhibits HIF-1 activity primarily by suppressing tumor cell respiration via the blockade of NADH-ubiquinone oxidoreductase (complex I)-mediated mitochondrial electron transfer."
06/01/2015 - "In fact, recent findings show that the shift from glycolysis to re-established oxidative metabolism is required for certain steps of tumor progression, suggesting that mitochondrial function and, in particular, respiratory complex I are crucial for metabolic and hypoxic adaptation. "
01/01/2015 - "Anti-cancer analogues ME-143 and ME-344 exert toxicity by directly inhibiting mitochondrial NADH: ubiquinone oxidoreductase (Complex I)."
11/01/2014 - "SERPINB3 may also contribute to tumor cell resistance to anti-neoplastic drugs through its binding to the respiratory Complex I, protecting cells from the pro-oxidant action of chemotherapeutic agents. "
06/01/2014 - "The m.3571insC mutation in the MTND1 gene of respiratory complex I (CI) is commonly detected in oncocytic tumors, in which it causes a severe CI dysfunction leading to an energetic impairment when present above 83% mutant load. "
|2.||Stomach Neoplasms (Stomach Cancer)
11/01/2012 - "In conclusion, human gastric cancer is associated with decreased respiratory capacity, deficiency of the respiratory complex I of mitochondria, and improved coupling of succinate oxidation to phosphorylation in tumor tissue and adjacent atrophic mucosa. "
01/01/2015 - "Annonaceous acetogenin mimic AA005 reportedly inhibits mammalian mitochondrial NADH-ubiquinone reductase (Complex I) and induces gastric cancer cell death. "
07/01/2014 - "Rotenone, a mitochondrial respiratory complex I inhibitor, ameliorates lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice."
01/01/2015 - "It was estimated, that under the conditions of acute acetaminophen-induced hepatitis of rats kept on a low-protein diet during 4 weeks a significant decrease of the NADH:ubiquinone reductase and succinate dehydrogenase activity with simultaneous increase of the ratio between redox forms of the nicotinamide coenzymes (NAD+/NADH) is observed compared to the same indices in the liver cells of animals with experimental hepatitis kept on the ration balanced by all nutrients. "
|4.||Body Weight (Weight, Body)
12/01/2012 - "Prophylactic administration of O(3)-O(2) mixture to 3 month-old rats, at an intrarectal dose of 0.6 mg O(3) kg(-1) body weight twice/week for 3 months then once/week until the age of 15 months, normalized reduced glutathione content, adenosine triphosphate/adenosine diphosphate ratio, mitochondrial superoxide dismutase (SOD) and complex IV (cytochrome-c oxidase) activities, improved glutathione redox index (GSHRI), complex I (NADH-ubiquinone oxidoreductase) and mitochondrial nitric oxide synthase (mtNOS) activities, and attenuated the rise in malondialdehyde (MDA) and mitochondrial protein carbonyl levels. "
06/01/1983 - "It was shown that the contents of vitamin E and ubiquinone as well as the activities of succinate- and NADH-ubiquinone reductase, succinate- and NADH-dehydrogenases in liver mitochondria are increased and the levels of ATP, adenine nucleotides and phosphate potential in the livers of vitamin E-deficient rats are elevated 3 hours after alpha-tocopherol injection (5 micrograms per 1 g of body weight). "
05/01/2008 - "RESULTS; We have made the following novel observations: 1) BBR dose-dependently inhibited respiration in L6 myotubes and muscle mitochondria, through a specific effect on respiratory complex I, similar to that observed with metformin and rosiglitazone; 2) activation of AMPK by BBR did not rely on the activity of either LKB1 or CAMKKbeta, consistent with major regulation at the level of the AMPK phosphatase; and 3) a novel BBR derivative, dhBBR, was identified that displayed improved in vivo efficacy in terms of counteracting increased adiposity, tissue triglyceride accumulation, and insulin resistance in high-fat-fed rodents. "
|1.||Electron Transport Complex IV (Cytochrome c Oxidase)
|3.||Adenosine Triphosphate (ATP)
|4.||Succinic Acid (Succinate)
|5.||Glutathione (Reduced Glutathione)
|7.||Calcium-Calmodulin-Dependent Protein Kinase Kinase
|8.||Mitochondrial Proteins (Mitochondrial Protein)
|9.||Nitric Oxide Synthase (NO Synthase)
|1.||Protein-Restricted Diet (Diet, Protein Restricted)
|2.||Drug Therapy (Chemotherapy)