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Cytochrome-B(5) Reductase (Methemoglobin Reductase)

A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.
Also Known As:
Methemoglobin Reductase; NADH Cytochrome B5 Reductase; NADH Methemoglobin Reductase; NADH-Cytochrome B5 Reductase; NADH-Ferrihemoglobin Reductase; B5 Reductase, NADH-Cytochrome; Methemoglobin Reductase, NADH; NADH Ferrihemoglobin Reductase; Reductase, Methemoglobin; Reductase, NADH Methemoglobin; Reductase, NADH-Ferrihemoglobin
Networked: 114 relevant articles (2 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Alhomida, A S: 4 articles (03/2002 - 07/2000)
2. Siddiqi, N J: 4 articles (03/2002 - 07/2000)
3. Srivastava, S: 4 articles (03/2002 - 07/2000)
4. Warang, Prashant: 3 articles (12/2015 - 05/2008)
5. Colah, Roshan B: 3 articles (03/2011 - 01/2002)
6. Ghosh, Kanjaksha: 3 articles (03/2011 - 01/2002)
7. Kedar, Prabhakar S: 3 articles (03/2011 - 01/2002)
8. Pandey, V C: 3 articles (03/2002 - 05/2001)
9. Ketsa, O V: 2 articles (07/2016 - 11/2013)
10. Marchenko, M M: 2 articles (07/2016 - 11/2013)

Related Diseases

1. Parasitemia
2. Sarcoma (Soft Tissue Sarcoma)
3. Congenital Methemoglobinemia
4. Methemoglobinemia
5. Cyanosis

Related Drugs and Biologics

1. Cytochromes b5 (Cytochrome b5)
2. NADPH-Ferrihemoprotein Reductase (Cytochrome P450 Reductase)
3. Methemoglobin
4. NADP (NADPH)
5. Cytochrome P-450 Enzyme System (Cytochrome P450)
6. artemotil (arteether)
7. Enzymes
8. NAD (NADH)
9. Oxidoreductases (Dehydrogenase)
10. Hemoglobins (Hemoglobin)

Related Therapies and Procedures

1. Transplantation
2. Contraindications