A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.
Also Known As:
Methemoglobin Reductase; NADH Cytochrome B5 Reductase; NADH Methemoglobin Reductase; NADH-Cytochrome B5 Reductase; NADH-Ferrihemoglobin Reductase; B5 Reductase, NADH-Cytochrome; Methemoglobin Reductase, NADH; NADH Ferrihemoglobin Reductase; Reductase, Methemoglobin; Reductase, NADH Methemoglobin; Reductase, NADH-Ferrihemoglobin