Cholestenone 5 alpha-Reductase (5 alpha-Reductase)

An oxidoreductase that catalyzes the conversion of 3-oxo-delta4 steroids into their corresponding 5alpha form. It plays an important role in the conversion of TESTOSTERONE into DIHYDROTESTOSTERONE and PROGESTERONE into DIHYDROPROGESTERONE.

Also Known As:

Networked: 284 relevant articles (7 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Schmidt, Lucy J: 3 articles (12/2009 - 11/2004)
2.	Tindall, Donald J: 3 articles (12/2009 - 11/2004)
3.	Hartmann, R W: 3 articles (11/2000 - 05/2000)
4.	Jung, Yunu: 2 articles (01/2019 - 01/2018)
5.	Kang, JongWook: 2 articles (01/2019 - 01/2018)
6.	Kim, Hye-Lin: 2 articles (01/2019 - 01/2018)
7.	Kwak, Hyun Jeong: 2 articles (01/2019 - 01/2018)
8.	Lim, Seona: 2 articles (01/2019 - 01/2018)
9.	Park, Jinbong: 2 articles (01/2019 - 01/2018)
10.	Song, Gahee: 2 articles (01/2019 - 01/2018)

Related Diseases

1.	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 09/01/1991 - "Magnetic resonance imaging of the efficacy of specific inhibition of 5 alpha-reductase in canine spontaneous benign prostatic hyperplasia." 10/01/2022 - "Therapeutic role of Glycyrrhiza Uralensis fisher on benign prostatic hyperplasia through 5 alpha reductase regulation and apoptosis." 03/01/2007 - "Medline searches for the keywords benign prostatic hyperplasia, BPH, alpha blockers, 5 alpha-reductase, and quality of life were performed. " 02/01/2003 - "Heterogeneity of 5 alpha-reductase gene expression in benign prostatic hyperplasia." 01/01/2002 - "Tested for inhibition of human 5 alpha-reductase 1 and 2--a target for the treatment of benign prostatic hyperplasia (BPH)--the title compounds showed some inhibitory activity."
2.	Alopecia (Baldness) 01/01/2009 - "Serenoa repens is one among the many naturally occurring 5 alpha reductase (5aR) inhibitors which has gained popularity as a magical remedy for androgenetic alopecia. " 06/01/2001 - "Recent studies suggest that 5 alpha-reductase type 2 (5 alpha R2) rather than 5 alpha R1 plays a key role in the pathogenesis of male-pattern baldness. " 07/01/2003 - "These results are compatible with the idea that 5 alpha-reductase inhibition is of no therapeutical value in female-pattern baldness." 12/01/2001 - "In the majority of men with male pattern baldness endogenous production of DHT is markedly increased, providing a rationale for therapeutic 5 alpha-reductase inhibition in this disorder." 03/01/1999 - "Recent experimental data enable us to explain some pathogenetic steps suggesting a pivotal role of type 2 5 alpha-reductase in the pathogenesis of androgenetic hair loss. "
3.	Prostatic Neoplasms (Prostate Cancer) 09/01/2012 - "Two randomised trials and negative conclusion of the FDA about inhibitors of 5 alpha-reductase in prevention of prostate cancer need a revision of the indications of these drugs. " 01/01/1997 - "Consequently, the odds ratios may be underestimated and the study, although negative, cannot exclude the previously hypothesized possibility that a positive relationship between intraprostatic 5 alpha-reductase activity and prostate cancer may exist. " 11/01/2002 - "Furthermore, 5 alpha-reductase which catalyze the conversion of T to DHT, has been a target of manipulation in the treatment of prostatic cancer, hence synthetic 5 alpha-reductase activity inhibitors have shown therapeutic promise. " 03/01/1997 - "A polymorphism of the 5 alpha-reductase gene and its association with prostate cancer: a case-control analysis." 01/01/1997 - "5 alpha-reductase activity and prostate cancer: a case-control study using stored sera."
4.	Androgen-Insensitivity Syndrome (Testicular Feminization) 10/01/1990 - "Gonadal histology was investigated by means of conventional microscopy in 6 patients with complete androgen insensitivity syndrome, in 11 with incomplete androgen insensitivity syndrome, and in 3 with 5 alpha-reductase syndrome. " 03/01/1988 - "The activity of 5 alpha-reductase in genital and supra-pubic skin (homogenate or fibroblasts) from subjects with complete or incomplete androgen insensitivity syndrome was low compared with mean activity in samples from normally differentiated male controls. " 03/01/1988 - "Evidence for secondary 5 alpha-reductase deficiency in genital and supra-pubic skin of subjects with androgen insensitivity syndrome." 12/15/1984 - "The prenatal diagnosis of 5 alpha-reductase deficiency or complete androgen insensitivity syndrome (testicular feminization) is thus theoretically possible and obviously prenatal testing would be indicated in the family at high risk." 01/01/2020 - "The study involved 59 patients with DSD (gonadal dysgenesis - GD, androgen insensitivity syndrome - AIS, 5-alpha reductase deficiency, ovotestis), and with the Y chromosome in the karyotype, aged 16-65 years. "
5.	Hyperplasia 01/01/1993 - "Thus, in older prostates with benign hyperplasia the activity of 5 alpha-reductase is almost the same in both compartments. " 10/01/1988 - "They also imply that both the augmentation of 5 alpha-reductase activity in hyperplastic stroma and the condition of benign hyperplasia of the prostate are mutual consequences of a primary increase in Km." 03/01/1990 - "From these data, it seems reasonable to conclude that sufficient levels of LH are essential for the induction of IC tumors or hyperplasia and the maintenance of tumor mass, and that the low production of T in the tumors is due, at least in part, to decreased 17 alpha-hydroxylase and increased 5 alpha-reductase activities under active steroidogenesis." 01/01/1996 - "Finasteride, which has a higher affinity for the type 2 isozyme, is the first 5 alpha-reductase antagonist clinically introduced for treatment of benign prostate hyperplasia. " 08/01/1993 - "Current research knowledge on the basics of benign prostate hyperplasia, several experimental and clinical reports in the ENT literature together with our own experimental results, are leading to a new and hopeful therapeutic opportunity for the future, involving the blocking of 5 alpha reductase as the enzyme which manages the DHT formation from testosterone.(ABSTRACT TRUNCATED AT 250 WORDS)"

Related Drugs and Biologics

1.	Dihydrotestosterone (Androstanolone)
2.	Dutasteride (Avodart)
3.	Testosterone (Sustanon)
4.	Finasteride (Propecia)
5.	Nitrogen
6.	Esters
7.	Adrenal Cortex Hormones (Corticosteroids)
8.	Androgens
9.	Enzymes
10.	Isoenzymes

Related Therapies and Procedures

1.	Skin Transplantation (Skin Grafting)
2.	Therapeutics
3.	Low-Level Light Therapy (LLLT)
4.	Orchiectomy (Orchidectomy)
5.	Castration