|1.||Roman, Richard J: 9 articles (10/2015 - 02/2005)|
|2.||Falck, John R: 8 articles (10/2015 - 07/2004)|
|3.||Fan, Fan: 3 articles (10/2015 - 05/2012)|
|4.||Capdevila, Jorge H: 3 articles (07/2015 - 09/2007)|
|5.||Hardwick, James P: 3 articles (01/2015 - 06/2008)|
|6.||Guo, Meng: 3 articles (04/2006 - 02/2005)|
|7.||Edwards, Paul A: 3 articles (04/2006 - 02/2005)|
|8.||Scicli, A Guillermo: 3 articles (04/2006 - 02/2005)|
|9.||Muroya, Yoshikazu: 2 articles (10/2015 - 10/2012)|
|10.||Garrett, Michael R: 2 articles (10/2015 - 12/2008)|
|1.||Hypertension (High Blood Pressure)
07/01/2014 - "In mice, Cyp4a deficiency results in salt-sensitive hypertension through activation of ENaC. "
08/01/2008 - "Cyp4a deficiency causes hypertension in male mice, and a loss-of-function variant (T8590C) of CYP4A11 is associated with hypertension in white individuals. "
08/01/2004 - "These results suggest that increased CYP4A and COX-2 protein levels and decreased CYP2C11 and CYP2C23 protein levels occur in association with microalbuminuria during the onset of obesity-related hypertension and type 2 diabetes."
05/15/2012 - "This study examined whether substitution of chromosome 5 containing the CYP4A genes from Brown Norway rat onto the Dahl S salt-sensitive (SS) genetic background upregulates the renal production of 20-HETE and attenuates the development of hypertension. "
06/01/1993 - "The present study examined whether long-term induction of renal fatty acid omega-hydroxylase with clofibrate would alter the development of hypertension in Dahl SS/Jr rats. "
02/01/2005 - "TOH-omega-hydroxylase activity was undetectable in rat primary lung type II cells, suggesting that expression of activity was associated with transformation of normal type II cells to cancer cells. "
07/01/2012 - "Real-Time PCR, western blot and immunohistochemistry were used to compare the expression of CYP4A/F mRNA and protein levels in human cancer tissue samples versus normal controls. "
01/01/2013 - "A recent observation that the expression of CYP4A/4F genes was markedly elevated in thyroid, breast, colon, and ovarian cancer further highlights the significance of 20-HETE-producing enzymes in the progression of different types of human cancer. "
04/01/2006 - "9L gliosarcoma cell proliferation and tumor growth in rats are suppressed by N-hydroxy-N'-(4-butyl-2-methylphenol) formamidine (HET0016), a selective inhibitor of CYP4A."
07/01/2012 - "The present finding of elevated expression of CYP4A/F enzymes in human cancer tissue suggests that 20-HETE inhibitors and antagonists may be useful in the treatment of cancer."
|3.||Genetic Predisposition to Disease (Genetic Predisposition)
|4.||Cardiovascular Diseases (Cardiovascular Disease)
01/01/2009 - "We finally propose a hypothesis that increased CYP4A expression with a decrease in CYP4F genes may promote the progression of steatosis to steatohepatitis."
07/01/2003 - "Conversely, we assessed dietary steatohepatitis in PPARalpha(-/-) mice that cannot up-regulate Cyp4a. "
01/01/2009 - "Although numerous studies have suggested the role ethanol-inducible CYP2E1 in contributing to increased oxidative stress, Cyp2e1-null mice still develop steatohepatitis with a dramatic increase in CYP4A gene expression. "
01/01/2009 - "In this review and tutorial, we briefly describe how fatty acids are partitioned by fatty acid transport proteins to either anabolic or catabolic pathways regulated by PPARs, and we explore how medium-chain fatty acid (MCFA) CYP4A and long-chain fatty acid (LCFA) CYP4Fomega-hydroxylase genes are regulated in fatty liver. "
01/01/2009 - "This strongly implies that CYP4A fatty acid omega-hydroxylase P450s may play an important role in the development of steatohepatitis. "
|3.||Arachidonic Acid (Vitamin F)
|4.||Alkane 1-Monooxygenase (Alkane 1 Monooxygenase)
|5.||Cytochrome P-450 Enzyme System (Cytochrome P450)
|6.||Cytochrome P-450 CYP2E1 (CYP2E1)
|7.||Hydroxyeicosatetraenoic Acids (HETE)
|8.||Mixed Function Oxygenases (Monooxygenases)
|10.||Ethanol (Ethyl Alcohol)