CDC2-CDC28 Kinases (CDC2 CDC28 Kinases)

A family of cell cycle-dependent kinases that are related in structure to CDC28 PROTEIN KINASE, S CEREVISIAE and the CDC2 PROTEIN KINASE found in mammalian species.

Also Known As:

CDC2 CDC28 Kinases; CDC2+-CDC28-related Protein Kinase; CDC2-Related Kinase; CDC28-Related Kinases; CDC2 Related Kinase; CDC2 Related Kinases; CDC2+ CDC28 related Protein Kinase; CDC28 Related Kinases; CDC2-Related Kinases

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bièche, Ivan: 1 article (10/2017)
2.	Gusscott, Samuel: 1 article (10/2017)
3.	Hasan, Mohammad R: 1 article (10/2017)
4.	Kennecke, Hagen F: 1 article (10/2017)
5.	Pasiliao, Clarissa C: 1 article (10/2017)
6.	Rahman, Mahbuba: 1 article (10/2017)
7.	Ren, Jianhua: 1 article (10/2017)
8.	Schaeffer, David F: 1 article (10/2017)
9.	Tai, Isabella T: 1 article (10/2017)
10.	Vacher, Sophie: 1 article (10/2017)

Related Diseases

1.	Neoplasms (Cancer) 03/15/1995 - "In particular, two of the kinases, cdk3 and PISSLRE and PITALRE, the cdc2-related kinases recently cloned by us, map to regions previously shown to exhibit loss of heterozygosity in breast and other tumors." 12/01/1991 - "Here we consider the intriguing possibility that phosphorylation by cdc2-related kinases may be the molecular mechanism linking cholinesterases with tumor cell proliferation. "
2.	Colorectal Neoplasms (Colorectal Cancer) 10/01/2017 - "Cyclin-dependent kinase 10 (CDK10), a CDC2-related kinase, is highly expressed in colorectal cancer. "
3.	Malaria 10/24/1996 - "Pfmap-1, a gene encoding a novel protein kinase, has been identified in the human malaria parasite Plasmodium falciparum, using the polymerase chain reaction with degenerate oligodeoxyribonucleotides designed to hybridise to conserved regions of cdc2-related kinases. "
4.	Alzheimer Disease (Alzheimer's Disease) 01/01/1995 - "This 33-kd Cdc2-related kinase is present in intracellular neurofibrillary tangles in neurons of elderly humans and in Alzheimer's disease, and it is associated with paired helical filaments (PHF) from Alzheimer's disease brains. " 01/01/1995 - "By virtue of its physical association with PHF, the 33-kd Cdc2-related kinase may play a role in transforming normal Tau proteins to PHF-Tau characteristic of Alzheimer's disease." 01/01/1995 - "Unlike the antibodies to the carboxyl and amino termini of p34Cdc2, antibodies to an abundant brain Cdc2-related kinase PSSLARE/Cdk5 did not immunolabel Alzheimer's disease neurofibrillary lesions. "

Related Drugs and Biologics

1.	Cyclin-Dependent Kinases (cdk Proteins)
2.	tau Proteins (tau Protein)
3.	Protein Kinases (Protein Kinase)
4.	Phosphotransferases (Kinase)
5.	Oligodeoxyribonucleotides
6.	Cholinesterases (Cholinesterase)
7.	Antibodies