TIE-1 Receptor (Receptor, TIE 1)

A TIE receptor found predominantly on ENDOTHELIAL CELLS. It is considered essential for vascular development and can form a heterodimer with the TIE-2 RECEPTOR. The TIE-1 receptor may play a role in regulating BLOOD VESSEL stability and maturation.

Also Known As:

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Alitalo, Riitta: 1 article (04/2007)
2.	Kivivuori, Sanna-Maria: 1 article (04/2007)
3.	Porkka, Kimmo: 1 article (04/2007)
4.	Saarinen-Pihkala, Ulla: 1 article (04/2007)
5.	Siitonen, Sanna: 1 article (04/2007)
6.	Vettenranta, Kim: 1 article (04/2007)
7.	Blumenthal, Rosalyn D: 1 article (04/2002)
8.	Craig, Russell: 1 article (04/2002)
9.	Goldenberg, David M: 1 article (04/2002)
10.	Osorio, Louis: 1 article (04/2002)

Related Diseases

1.	Vascular Remodeling 11/01/2000 - "Unlike VEGF, angiopoietin (Ang)-1 and -2, their receptor tie-2, and the associated receptor tie-1 exert their functions at later stages of vascular development, i.e., during vascular remodeling and maturation. "
2.	Neoplasms (Cancer) 04/01/2002 - "In Calu-3, PlGF mRNA increased 8-fold at week 5. PlGF was detected in hypoxic areas at week 2. Vascular expression of orphan receptor Tie-1 increased in all four of the tumors by week 2 (LoVo, GW-39, and Calu-3, P < 0.05). "
3.	Leukemia 04/01/2007 - "Activation of vascular endothelial growth factor receptor 3 (VEGFR-3) and Tie1 tyrosine kinase receptor are known to promote leukemia cell survival. " 04/01/2007 - "Expression of vascular endothelial growth factor receptor 3 and Tie1 tyrosine kinase receptor on acute leukemia cells."

Related Drugs and Biologics

1.	TIE-2 Receptor (Receptor, TIE 2)
2.	Angiopoietins
3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4.	Vascular Endothelial Growth Factor Receptor-3 (Flt 4)
5.	Messenger RNA (mRNA)