|1.||David, Sascha: 5 articles (06/2012 - 01/2008)|
|2.||Lip, G Y H: 5 articles (10/2005 - 07/2003)|
|3.||Kümpers, Philipp: 4 articles (05/2012 - 01/2008)|
|4.||Haller, Hermann: 4 articles (05/2012 - 01/2008)|
|5.||Lieb, Wolfgang: 3 articles (04/2015 - 12/2013)|
|6.||Wallaschofski, Henri: 3 articles (04/2015 - 12/2013)|
|7.||Lorbeer, Roberto: 3 articles (04/2015 - 12/2013)|
|8.||Völzke, Henry: 3 articles (04/2015 - 12/2013)|
|9.||Vasan, Ramachandran S: 3 articles (04/2015 - 12/2013)|
|10.||Nauck, Matthias: 3 articles (04/2015 - 12/2013)|
02/01/2006 - "Many studies showed that disrupting the ANGPT/TEK receptor pathway could inhibit the growth of a number of murine tumors and human tumors. "
06/07/2005 - "Previous studies with intrabodies had demonstrated that the Tie-2 receptor pathway was essential for tumor growth. "
07/01/2015 - "Considering that germ cells (the cell population from which NGCO originates) constitutively express Tie2 receptor, it can be speculated that Tie2-driven deletion of Trp53 may have played a role in the development of these tumors. "
05/01/2012 - "We have generated MEDI3617, a human anti-Ang2 monoclonal antibody that neutralizes Ang2 by preventing its binding to the Tie2 receptor in vitro, and inhibits angiogenesis and tumor growth in vivo. "
04/01/2011 - "Expression of its receptor, TIE2, defines a highly proangiogenic subpopulation of myeloid cells in circulation and tumors called TIE2-expressing monocytes/macrophages (TEMs). "
|3.||Colorectal Neoplasms (Colorectal Cancer)
01/01/2014 - "To study the expression of angiogenin-2 (Ang-2) and its receptor Tie-2 in colorectal cancer and discuss the possible mechanisms behind this process. "
12/01/2009 - "THE AIM OF THE STUDY was to compare the angiopoietin-1(Ang-1), angiopoietin-2 (Ang-2) and Tie-2 receptor (rec. Tie-2) concentrations in the serum of colorectal cancer patients with concentrations of these factors in the serum of healthy people. "
08/01/2003 - "Vascular endothelial growth factor and soluble Tie-2 receptor in colorectal cancer: associations with disease recurrence."
02/19/2013 - "This phase 2 study evaluated trebananib (AMG 386), an investigational peptide-Fc fusion protein that neutralises the interaction between angiopoietins-1/2 and the Tie2 receptor, plus FOLFIRI as second-line treatment for patients with metastatic colorectal cancer. "
|4.||Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
05/01/2010 - "The purpose of this study was to elucidate whether the soluble domain of the Tie2 receptor (sTie2)predicts outcome in patients with acute myeloid leukemia(AML) undergoing allogeneic hematopoietic stem cell transplantation(HSCT). "
02/01/2002 - "The expression of both the TEK receptor and its ligand in acute myeloid leukemia (AML) and CML patients might, therefore, suggest an involvement of these genes in the pathogenesis of myeloproliferative disorders."
09/01/2006 - "Expression of angiopoietins and their receptor Tie2 in the bone marrow of patients with acute myeloid leukemia."
03/01/2009 - "The aim of the present study is to the assess the impact of the circulating levels of angiopoietin-1 (Angi-1), Angiopoietin-2 (Angi-2), soluble Tie2 receptor (sTie2), and calculated Angi-2/sTie2 ratio on overall survival in 71 acute myeloid leukemia patients and 19 normal controls. "
|5.||Psoriasis (Pustulosis Palmaris et Plantaris)
04/01/2009 - "One previous psoriasis model demonstrated that overexpression of the angiopoietin receptor Tie2 in endothelial cells and keratinocytes led to the development of a psoriasiform phenotype; however, the etiological significance of overexpression in each cell type alone was unclear. "
05/01/2001 - "In this study we examined the potential role of angiopoietins and the Tie2 receptor in vascular changes of psoriasis. "
04/01/2011 - "In mice engineered to overexpress the angiopoietin receptor Tie2 in KCs, skin spontaneously develops the characteristic clinical, histological and immune cell phenotypes of psoriasis which can be reversed with either transgene repression or ciclosporin administration, suggesting key roles for both KCs and T cells in mediating the skin disease in this murine model. "
03/01/2005 - "Recently, a role for the angiopoietin signaling system in psoriasis has been suggested by studies that demonstrate an up-regulation of the tyrosine kinase receptor Tie2 (also known as Tek) as well as angiopoietin-1 and angiopoietin-2 in human psoriatic lesions. "
|6.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
|7.||Protein-Tyrosine Kinases (Tyrosine Kinase)
|9.||Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
|1.||Hematopoietic Stem Cell Transplantation
|4.||Drug Therapy (Chemotherapy)