Angiopoietins

01/30/2015 - "Elucidating Ang2-dependent mechanisms of vascular destablization is critical for rational design of angiopoietin antagonists that have demonstrated therapeutic efficacy in cancer trials. "
01/01/2022 - "Recent studies have found that angiopoietin-like 4 (ANGPTL4) is abnormally expressed in many tumors, so it can serve as a potential prognostic marker and therapeutic target. "
12/20/2023 - "Therapeutic targeting of angiopoietins in tumor angiogenesis and cancer development."
11/21/2023 - "Attenuating Epithelial-to-Mesenchymal Transition in Cancer through Angiopoietin-Like 4 Inhibition in a 3D Tumor Microenvironment Model."
01/01/2023 - "By performing spatially focused transcriptional profiling, we identified angiopoietin-like 7 (Angptl7) as a tumor-specific factor localized to the perinecrotic zone. "

10/16/2013 - "This study adds to the evidence that angiopoietins are early markers of endothelial dysfunction in sepsis and provide prognostic information regarding outcomes. "
01/01/2020 - "Our findings suggest that angiopoietin dysregulation begins early in sepsis and, if sustained, may promote greater organ injury that can lead to worse clinical outcomes."
01/01/2020 - "However, the relationship of plasma angiopoietins with organ injury and clinical outcomes in children with sepsis remains unknown. "
01/01/2018 - "Angiopoietin-Tie2 axis) would identify young infants with sepsis and predict their clinical outcome. "
01/01/2018 - "Perturbations to the angiopoietin (Ang)/Tie2 axis cause endothelial cell activation and contribute to the pathogenesis of sepsis. "

11/01/2019 - "Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice."
11/01/2017 - "Previous studies including some vivo experiments and large scale clinical trials have indicated that angiopoietin like 4 (ANGPTL4) is involved in atherosclerosis. "
01/01/2021 - "Targeting angiopoietin-like 3 in atherosclerosis: From bench to bedside."
01/01/2019 - "To understand tissue-specific regulation of angiopoietin/angiopoietin-like (ANGPT/ANGPTL) genes (especially the five genes embedded in introns of host genes) and their association with atherosclerosis. "
01/01/2017 - "Angiopoietin-like 2 has auxo-action in atherosclerosis by promoting atherosclerotic calcification."

09/01/2019 - "Previous studies showed altered angiopoietin-like protein-8 (ANGPTL-8) circulating levels in type 2 diabetes mellitus (DM). "
12/01/2023 - "Peripheral sensory neuropathy is associated with circulating angiopoietins in type 2 diabetes patients in Ghana."
09/01/2019 - "The potential role of angiopoietin-like protein-8 in type 2 diabetes mellitus: a possibility for predictive diagnosis and targeted preventive measures?"
01/01/2018 - "To investigate whether angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) are differentially associated with the severity of retinopathy in patients with type 2 diabetes mellitus (T2DM). "
09/01/2018 - "Biphasic changes in angiopoietin-like 8 level after laparoscopic sleeve gastrectomy and type 2 diabetes remission during a 1-year follow-up."

11/28/2016 - "Finally, the accuracy, sensitivity and specificity of circulating angiopoietins for cirrhosis diagnosis were determined by the study of the respective area under the curve of receiver operator characteristics (AUC-ROC). "
09/15/2013 - "In the present study, we investigate the effect of renal I/R on the dynamics of angiopoietin expression and its association with pericytes and fibrosis development. "
11/28/2016 - "Interestingly, the individual performance of each angiopoietin for the diagnosis of cirrhosis reached notable AUC-ROC values (above 0.7, both), but the Ang2/Ang1 ratio was much better (AUC-ROC = 0.810) and displayed outstanding values of sensitivity (71%), specificity (84%) and accuracy (82.1%) at the optimal cut-off (10.33). "
11/28/2016 - "Subsequently, the association of peripheral concentrations of angiopoietins with the stage of fibrosis was analyzed using Spearman correlation test. "
09/15/2013 - "Our findings suggest that angiopoietins and pericytes play an important role in renal microvascular remodeling and development of fibrosis. "