Vascular Endothelial Growth Factor B

A vascular endothelial growth factor expressed in a variety of tissues. It binds with high specificity to VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 and NEUROPILIN-1.

Also Known As:

VEGF-B; VEGF-Related Factor, VEGF-B; VEGF-Related Protein, VEGF-B; Vascular Endothelial Growth Factor-B; VEGF Related Factor, VEGF B; VEGF Related Protein, VEGF B; VEGF-B VEGF-Related Factor; VEGF-B VEGF-Related Protein

Networked: 270 relevant articles (11 outcomes, 49 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Alitalo, Kari: 15 articles (01/2021 - 02/2005)
2.	Eriksson, Ulf: 13 articles (01/2020 - 09/2003)
3.	Kivelä, Riikka: 11 articles (01/2021 - 07/2006)
4.	Carmeliet, Peter: 11 articles (04/2016 - 09/2003)
5.	Ylä-Herttuala, Seppo: 9 articles (12/2021 - 08/2005)
6.	Li, Xuri: 8 articles (01/2019 - 03/2008)
7.	Shibuya, Masabumi: 8 articles (01/2016 - 09/2008)
8.	Li, Jing: 6 articles (01/2021 - 05/2014)
9.	Liu, Jie: 6 articles (01/2021 - 05/2014)
10.	Qi, Zhi: 6 articles (01/2021 - 05/2014)

Related Diseases

1.	Insulin Resistance 08/29/2014 - "Additionally, recent studies have shown that Vegf-b deficiency protects from high-fat diet (HFD)-induced diabetes and insulin resistance. " 03/01/2016 - "VEGF-B levels were correlated with body mass index, body fat percentage, M values, homeostasis model assessment of insulin resistance and β-cell function indices. " 10/18/2012 - "Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes." 03/01/2016 - "Serum VEGF-B is significantly higher in women with polycystic ovary syndrome and is closely and positively related to insulin resistance. " 03/01/2016 - "Metformin treatment reduces VEGF-B levels and ameliorates insulin resistance."
2.	Diabetic Nephropathies (Diabetic Nephropathy) 01/01/2017 - "Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease." 01/01/2022 - "Serum VEGF-B level is associated with renal function impairment in patients with type 2 diabetes and may be a potential drug target for diabetic kidney disease." 01/16/2023 - "Simultaneous blockade of VEGF-B and IL-17A ameliorated diabetic kidney disease by reducing ectopic lipid deposition and alleviating inflammation response." 01/01/2021 - "VEGF-B antibody and interleukin-22 fusion protein ameliorates diabetic nephropathy through inhibiting lipid accumulation and inflammatory responses."
3.	Neoplasms (Cancer) 11/15/2016 - "To study this, we administered an adeno-associated viral vector expressing VEGF-B or control vector to normal and tumor-bearing mice 1 wk before DOX treatment, using doses mimicking the concentrations used in the clinics. " 01/01/2023 - "Mechanistically, we unveil that VEGF-B binds to FGFR1, induces FGFR1/VEGFR1 complex formation, and suppresses FGF2-induced Erk activation, and inhibits FGF2-driven angiogenesis and tumor growth. " 09/30/2021 - "Furthermore, differences in VEGF-B, FLT1, ERBB2, GRB2, RAC1, CDH1 and HYAL-1 genes expression have been found in different breed dogs (German Shepherd, Yorkshire Terrier) and mixed-breed dogs indicating that a dog's breed could determine a molecular difference, outcome of cancer and should be accounted as a confounding factor in the future gene expression research." 01/01/2021 - "Furthermore, we found that the anti-tumor effect in combination group was dramatically weakened after VEGF-B overexpressed in PaCa cells. " 01/01/2021 - "Therefore, we assumed that a pharmacological inhibitor of VEGF-B should potentiate the anti-tumor effect of RSV on PaCa. "
4.	Type 2 Diabetes Mellitus (MODY) 10/01/2023 - "Vascular endothelial growth factor B (VEGFB) plays a crucial role in glucolipid metabolism and is highly associated with type 2 diabetes mellitus (T2DM). " 10/01/2023 - "Vascular endothelial growth factor B regulates insulin secretion in β cells of type 2 diabetes mellitus mice via PLCγ and the IP3R‑evoked Ca2+/CaMK2 signaling pathway." 01/01/2022 - "Serum VEGF-B levels evaluated in type 2 diabetes patients compared with healthy controls. " 01/01/2022 - "Serum VEGF-B levels were measured in 213 patients with type 2 diabetes and 31 healthy participants. " 01/01/2022 - "Increased Serum VEGF-B Level Is Associated With Renal Function Impairment in Patients With Type 2 Diabetes."
5.	Metabolic Syndrome (Dysmetabolic Syndrome X) 11/01/2022 - "Serum vascular endothelial growth factor b and metabolic syndrome incidence in the population based cohort [email protected] study." 07/15/2020 - "Here, we reported tPep-VEGF-B diminishes obesity and alleviates metabolic syndrome. " 10/18/2012 - "Pharmacological inhibition of VEGF-B signalling by antibody administration to db/db mice enhanced glucose tolerance, preserved pancreatic islet architecture, improved β-cell function and ameliorated dyslipidaemia, key elements of type 2 diabetes and the metabolic syndrome. " 01/01/2018 - "Overall, VEGF-A, VEGF-B and VEGF-C were strongly associated with metabolic syndrome or its components. " 04/12/2016 - "(2016) demonstrate that VEGF-B, by displacing VEGF-A from VEGFR1 and activating VEGFR2, increases adipose tissue vascularity, improves insulin sensitivity, diminishes obesity, and alleviates metabolic syndrome. "

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Vascular Endothelial Growth Factor B
3.	Vascular Endothelial Growth Factor C
4.	Intercellular Signaling Peptides and Proteins (Growth Factors)
5.	Messenger RNA (mRNA)
6.	Proteins (Proteins, Gene)
7.	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)
8.	Lipids
9.	Glucose (Dextrose)
10.	Metformin (Glucophage)

Related Therapies and Procedures

1.	Therapeutics
2.	Herniorrhaphy
3.	Radiotherapy
4.	Aftercare (After-Treatment)
5.	Intravitreal Injections