Angiogenic Proteins

Intercellular signaling peptides and proteins that regulate the proliferation of new blood vessels under normal physiological conditions (ANGIOGENESIS, PHYSIOLOGICAL). Aberrant expression of angiogenic proteins during disease states such as tumorigenesis can also result in PATHOLOGICAL ANGIOGENESIS.

Also Known As:

Angiogenic Peptides; Peptide, Angiogenic; Protein, Angiogenic; Angiogenic Peptide; Angiogenic Protein

Networked: 403 relevant articles (13 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Karumanchi, S Ananth: 13 articles (10/2016 - 06/2005)
2.	Kataoka, Kazunori: 4 articles (01/2017 - 01/2011)
3.	Osada, Kensuke: 4 articles (01/2017 - 01/2011)
4.	Kumar, Vivek A: 3 articles (11/2021 - 01/2016)
5.	Shi, Siyu: 3 articles (11/2021 - 01/2016)
6.	Siddiqui, Zain: 3 articles (11/2021 - 03/2019)
7.	Rajakumar, Augustine: 3 articles (01/2019 - 10/2016)
8.	Banciu, Manuela: 3 articles (01/2018 - 06/2006)
9.	Rana, Sarosh: 3 articles (01/2017 - 01/2012)
10.	Hwang, Hyosook: 3 articles (11/2016 - 07/2015)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "Recently, studies on anti-angiogenic peptides have provided promising results in the field of cancer treatment. " 11/01/2020 - "This translational study highlights the difference in clinical impact between tumor and stromal expression of angiogenic proteins. " 11/01/2020 - "Angiogenic protein expression was measured using a bead-based immunoassay and correlated with tumor stage and overall survival. " 10/01/2019 - "Compared to the conventional preparation method, the coculture model of tumor-endothelial construction on an integrated platform displays high-level angiogenic protein expression. " 06/17/2019 - "Thus, reliably identifying anti-angiogenic peptides is extremely important for understanding their biophysical and biochemical properties that serve as the basis for the discovery of new anti-cancer drugs. "
2.	Ischemia 01/01/2016 - "To investigate therapeutic efficacy, hearts subjected to ischemia received PEGylated nanoliposomes encapsulated with angiogenic peptides. " 10/01/2000 - "Preclinical studies have shown that bFGF, an angiogenic peptide, promotes collateral development in animal models of myocardial and hind limb ischemia. " 03/28/2019 - "Challenges in Translating from Bench to Bed-Side: Pro-Angiogenic Peptides for Ischemia Treatment." 01/01/2016 - "Treatment of hind limb ischemia using angiogenic peptide nanofibers." 03/16/2004 - "Developmental endothelial locus-1 (Del-1), a novel angiogenic protein: its role in ischemia."
3.	Inflammation (Inflammations) 01/01/2020 - "Thrombospondin-4 (TSP4) is a pro-angiogenic protein that has been implicated in tissue remodeling and local vascular inflammation. " 08/01/2017 - "Systemic inflammation accompanied top quartile concentrations of every one of the 6 angiogenic proteins. " 01/01/2012 - "It is hypothesized that augmentation of local wound microenvironment with a stable provisional matrix formed by proteolysis-resistant angiogenic peptide nanofibers (NFs) will create permissive environment for attenuated inflammation, enhanced neovascularization, and improved diabetic wound healing. " 10/10/2019 - "Based on the similar inflammatory and angiogenic protein profile data from cochlear duct lysates, neither inflammation nor disturbed angiogenesis, as potential pathological components in sensorineural hearing losses, seem to be involved in the pathomechanism of the presented functional and morphological changes in PACAP KO mice. " 05/01/2018 - "We conclude that systemic levels of pro-inflammatory and angiogenic proteins are increased in patients with OA and rise further postoperatively, while proteins that restrain inflammation and angiogenesis do not coordinately rise. "
4.	Renal Cell Carcinoma (Grawitz Tumor) 05/03/2023 - "Author Correction: pVHL-mediated regulation of the anti-angiogenic protein thrombospondin-1 decreases migration of Clear Cell Renal Carcinoma Cell Lines." 01/01/2020 - "pVHL-mediated regulation of the anti-angiogenic protein thrombospondin-1 decreases migration of Clear Cell Renal Carcinoma Cell Lines." 07/28/2023 - "Emerging biomarkers such as gene expression profiles and the loss of pro-angiogenic proteins VHL and PBRM-1 show promise for identifying renal cell carcinoma cases likely to respond to ICI. " 07/01/2015 - "Combined Radiofrequency Ablation and Double Anti-Angiogenic Protein Therapy to Increase Coagulation Efficacy: An Experimental Study in a Murine Renal Carcinoma Model." 07/01/2015 - "To evaluate whether suppression of tumor microvasculature by double anti-angiogenic protein (DAAP) treatment could increase the extent of radiofrequency ablation (RFA)-induced coagulation in a murine renal cell carcinoma model. "
5.	Pancreatic Neoplasms (Pancreatic Cancer) 03/01/2016 - "We used the nanomicelles for treating intractable pancreatic cancer in a subcutaneous inoculation mouse model through the delivery of mRNA encoding an anti-angiogenic protein (sFlt-1). " 01/23/2003 - "Expression of vascular endothelial growth factor (VEGF), a key angiogenic protein, has been linked with pancreatic cancer progression. " 12/01/2010 - "Gastrointestinal bleeding during anti-angiogenic peptide vaccination in combination with gemcitabine for advanced pancreatic cancer." 12/01/2010 - "To confirm the feasibility and efficacy of a novel clinical intervention using tumor vessel-specific anti-angiogenic peptide vaccination, we conducted a clinical phase I/II trial using HLA-A2402/A0201-restricted vascular endothelial growth factor receptor type 1 (VEGFR1)-derived peptide vaccination in combination with gemcitabine for advanced pancreatic cancer (http://www.clinical-trials.gov; NCT00683358 and NCT00683085). "

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Proteins (Proteins, Gene)
3.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
4.	Peptides (Polypeptides)
5.	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
6.	Interleukin-2 (IL2)
7.	Phytoestrogens (Phytoestrogen)
8.	HLA-A Antigens (HLA-A)
9.	Gemcitabine
10.	Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1.	Cell Transplantation
2.	Transplantation
3.	Therapeutics
4.	Radiotherapy
5.	Chemoradiotherapy