4-Quinolones (4 Quinolones)

QUINOLONES containing a 4-oxo (a carbonyl in the para position to the nitrogen). They inhibit the A subunit of DNA GYRASE and are used as antimicrobials. Second generation 4-quinolones are also substituted with a 1-piperazinyl group at the 7-position and a fluorine at the 6-position.

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Networked: 66 relevant articles (4 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Feng, Lian-Shun: 2 articles (01/2018 - 12/2017)
2.	Zhang, Shu: 2 articles (01/2018 - 12/2017)
3.	Chawla-Sarkar, Mamta: 1 article (01/2021)
4.	Dutta, Shanta: 1 article (01/2021)
5.	Joshi, Mamata: 1 article (01/2021)
6.	Kanyalkar, Meena: 1 article (01/2021)
7.	Malbari, Khushboo: 1 article (01/2021)
8.	Rai, Swita: 1 article (01/2021)
9.	Saha, Priyanka: 1 article (01/2021)
10.	Chen, Ting: 1 article (01/2020)

Related Diseases

1.	Infections 05/01/1989 - "These studies indicate good chemotherapeutic potential for the new generation fluorinated 4-quinolones in infections induced by the staphylococci, streptococci, Enterobacteriaceae and P. " 01/01/1985 - "Clinical studies on a possible role for some of the more recently synthesised 4-quinolones in the management of patients with respiratory infection are indicated." 01/01/1991 - "The 4-quinolones are also unusual because even for serious infections they can be given orally. " 05/01/1989 - "A number of new fluorinated 4-quinolones were compared in acute systemic mouse-infection models with various Gram-positive cocci (streptococci and staphylococci), Enterobacteriaceae and Pseudomonas aeruginosa. " 05/01/1989 - "Comparative chemotherapeutic activity of new fluorinated 4-quinolones and standard agents against a variety of bacteria in a mouse infection model."
2.	Sepsis (Septicemia) 07/01/1989 - "Although short courses of 4-quinolones are effective in routine infections, longer courses are necessary for chronic, deep-seated sepsis. "
3.	Salmonella Infections (Salmonellosis) 11/01/1985 - "The infection resolved completely with ciprofloxacin therapy--a new 4-quinolone antibiotic which may have an important role in the treatment of systemic salmonella infections."
4.	Lipoid Nephrosis (Glomerulonephritis, Minimal Change) 02/01/1997 - "Pefloxacin, a fluorinated 4-quinolone, has recently been advocated as a first-line treatment for minimal-change nephropathy (MCN) or focal segmental glomerulosclerosis (FSGS). "
5.	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 02/01/1997 - "Pefloxacin, a fluorinated 4-quinolone, has recently been advocated as a first-line treatment for minimal-change nephropathy (MCN) or focal segmental glomerulosclerosis (FSGS). "

Related Drugs and Biologics

1.	Ciprofloxacin (Cipro)
2.	Anti-Bacterial Agents (Antibiotics)
3.	Pefloxacin
4.	Enoxacin (AT 2266)
5.	Colchicine
6.	Norfloxacin
7.	Fluoroquinolones
8.	Quinolones
9.	Ofloxacin (Ofloxacine)
10.	sarafloxacin

Related Therapies and Procedures

1.	Therapeutics
2.	Transurethral Resection of Prostate (TURP)
3.	Drug Therapy (Chemotherapy)
4.	Immunomodulation