HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)

The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
Also Known As:
Vascular Endothelial Growth Factor; VEGF; GD-VEGF; Glioma-Derived Vascular Endothelial Cell Growth Factor; VEGF-A; Vascular Permeability Factor; Vasculotropin; Glioma Derived Vascular Endothelial Cell Growth Factor; Permeability Factor, Vascular; Vascular Endothelial Growth Factor-A
Networked: 46221 relevant articles (2557 outcomes, 7686 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Wang, Wei: 108 articles (05/2022 - 03/2002)
2. Zhang, Wei: 89 articles (02/2022 - 01/2002)
3. Ferrara, Napoleone: 87 articles (01/2020 - 01/2002)
4. Li, Yan: 84 articles (06/2022 - 03/2002)
5. Carmeliet, Peter: 82 articles (01/2021 - 02/2002)
6. Campochiaro, Peter A: 73 articles (01/2022 - 02/2002)
7. Jain, Rakesh K: 73 articles (01/2021 - 03/2002)
8. Rini, Brian I: 71 articles (02/2022 - 04/2004)
9. Zhang, Li: 65 articles (05/2022 - 04/2002)
10. Wang, Yan: 64 articles (03/2022 - 09/2005)

Related Diseases

1. Neoplasms (Cancer)
03/01/2011 - "We found that the ratio of VEGF-A/sFLT-1 was increased not only in murine but also in human MA, and F-gene-deleted recombinant Sendai virus (rSeV/dF)-mediated secretion of human sFLT-1 by DCs augmented not only the activity of DCs themselves, but also dramatically improved the survival of tumor-bearing animals associated with enhanced CTL activity and its infiltration to peritoneal tumors. "
08/01/2014 - "An important question for the pediatric oncology research community, pharmaceutical companies, and regulatory agencies to address in planning for future clinical trials is whether existing data support a role for VEGF pathway targeted agents in contributing to a therapeutic pathway to cure for children with cancer."
12/01/2011 - "Pharmacological targeting of blood vessels, mainly through the VEGF signaling pathway, has proven effective in normalizing tumor vessels. "
08/01/2001 - "Lowered VEGF levels were associated with a marked decrease in the growth of nude mouse xenografted tumor (at 33 days postimplantation, tumor volume: 345.40 +/- 136.31 mm3)(P<0.05 vs control SGC-7901 group: 1534.40 +/- 362.88 mm3), whereas up-regulation of VEGF resulted in increased xenografted tumor size (at 33 days postimplantation, tumor volume: 2350.50 +/- 637.70 mm3) (P<0.05 vs control SGC-7901 group). "
10/01/2008 - "This study found that log(e)(VEGF/platelets) 1-2 days after TACE, but not log(e)(VEGF/platelets) at baseline, was strongly correlated with vascular or nodal invasion and AJCC (American Joint Committee on Cancer)/UICC (International Union Against Cancer) stage, and was significantly greater in men. "
2. Macular Degeneration (Age-Related Maculopathy)
3. Macular Edema
4. Hypoxia (Hypoxemia)
5. Colorectal Neoplasms (Colorectal Cancer)

Related Drugs and Biologics

1. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2. Bevacizumab (Avastin)
3. Monoclonal Antibodies
4. Proteins (Proteins, Gene)
5. Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
6. Retinaldehyde (Retinal)
7. Ranibizumab (Lucentis)
8. ErbB Receptors (EGF Receptor)
9. Messenger RNA (mRNA)
10. Intercellular Signaling Peptides and Proteins (Growth Factors)

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Injections
4. Intravitreal Injections
5. Lasers (Laser)