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Neuropilins

Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. NEUROPILIN-1 and NEUROPILIN-2 differ in their binding specificities, and are distributed complementarily in regions of the developing nervous system. Neuropilins are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial growth factors, and may form hetero- or homodimers. They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION.
Also Known As:
Neuropilin
Networked: 217 relevant articles (3 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Tamagnone, Luca: 8 articles (04/2019 - 04/2007)
2. Klagsbrun, Michael: 7 articles (01/2011 - 01/2002)
3. Demange, Luc: 4 articles (01/2021 - 07/2014)
4. Goel, Hira Lal: 4 articles (01/2019 - 01/2012)
5. Mercurio, Arthur M: 4 articles (01/2019 - 01/2012)
6. Drabkin, Harry A: 4 articles (01/2014 - 05/2005)
7. Roche, Joëlle: 4 articles (12/2013 - 01/2002)
8. Staton, Carolyn A: 4 articles (05/2013 - 10/2010)
9. Nie, Lei: 3 articles (04/2022 - 10/2009)
10. Sadeghi, Mehran M: 3 articles (04/2022 - 10/2009)

Related Diseases

1. Neoplasms (Cancer)
2. Breast Neoplasms (Breast Cancer)
3. Lung Neoplasms (Lung Cancer)
4. Neoplasm Metastasis (Metastasis)
5. Hypoxia (Hypoxemia)
01/01/2022 - "This manuscript describes the use of two chemical modifications, incorporating a neuropilin receptor agonist peptide (iRGD) and a hypoxia-responsive lipid for targeting and release of an encapsulated drug from bovine milk exosomes to triple-negative breast cancer cells. "
11/01/2011 - "Expressions of VEGF-A, hypoxia-inducible factor 1α, stromal cell-derived factor 1α, angiopoietin 1 and 2, MMP-2 and -9, VEGF receptors 1 and 2, neuropilin receptors 1 and 2, and CD133 messenger RNA were not elevated compared to control fat (P = 0.1). "
08/01/2012 - "We assessed relative messenger RNA (mRNA) and immunohistochemical (IHC) expression of Vascular Endothelial Growth Factors (VEGF) A, B, C, their receptors VEGFR1, 2, 3, Neuropilins 1, 2 (NRP1, 2) and Hypoxia-Inducible Factor 1A (HIF1A) in paraffin-embedded localised laryngeal carcinomas. "
12/01/2007 - "In an attempt to elucidate the relationship between biomarkers of tumor hypoxia, glycolysis and angiogenesis, we tested the hypothesis that intratumoral gene expression of the hypoxia response (hypoxia inducible factor [HIF1 alpha and 2 alpha]), glycolysis (lactate dehydrogenase A [LDHA]), glucose metabolism (glucose transporter-1 [Glut-1]) and genes involved in angiogenesis (i.e., VEGFA, VEGFR1-3, and neuropilin [NRP]1) are upregulated in metastatic colorectal cancer (mCRC) patients with high serum lactate dehydrogenase (LDH). "
10/01/2007 - "Abbreviations used: VEGF, Vascular endothelial growth factor; PLGF, placenta growth factor; NRP, neuropilin; HSPGs, heparan sulfate proteoglycans; FGF, fibroblast growth factor; TGF, transforming growth factor; HGF, hepatocyte growth factor; TNF, tumor necrosis factor; ECM, extracellular matrix; RTKs, receptor tyrosine kinases; ERK, extracellular signal kinases; HIF, hypoxia-inducible factor."

Related Drugs and Biologics

1. Semaphorins (Semaphorin)
2. Ligands
3. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4. Proteins (Proteins, Gene)
5. plexin
6. Intercellular Signaling Peptides and Proteins (Growth Factors)
7. Hepatocyte Growth Factor (Growth Factor, Hepatocyte)
8. Angiopoietins
9. Matrix Metalloproteinases (MMPs)
10. Cytokines

Related Therapies and Procedures

1. Therapeutics
2. Cryotherapy (Therapy, Cold)
3. Trabeculectomy (Trabeculoplasty)
4. Light Coagulation