HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Neural Cell Adhesion Molecule L1 (L1 Cell Adhesion Molecule)

A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.
Also Known As:
L1 Cell Adhesion Molecule; CALL Protein; CamL1 Gene Product; Cell Adhesion Molecule L1; Cell Surface Glycoprotein L1; F11 Glycoprotein; L1CAM; NGF-Inducible Glycoprotein; NILE Glycoprotein; NILE Protein; Nerve Growth Factor-Inducible Large External Glycoprotein; Neural Adhesion Molecule L1; Glycoprotein, NGF-Inducible; Glycoprotein, NILE; NGF Inducible Glycoprotein; Nerve Growth Factor Inducible Large External Glycoprotein
Networked: 271 relevant articles (2 outcomes, 36 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Altevogt, Peter: 34 articles (03/2015 - 07/2003)
2. Schachner, Melitta: 18 articles (06/2015 - 09/2002)
3. Schirmer, Uwe: 11 articles (11/2014 - 01/2010)
4. Moldenhauer, Gerhard: 10 articles (03/2015 - 01/2006)
5. Schäfer, Heiner: 10 articles (07/2014 - 01/2009)
6. Sebens, Susanne: 9 articles (01/2015 - 01/2010)
7. Kiefel, Helena: 9 articles (01/2014 - 06/2009)
8. Pfeifer, Marco: 9 articles (01/2013 - 01/2010)
9. Zeimet, Alain G: 7 articles (11/2014 - 04/2010)
10. Müller-Holzner, Elisabeth: 7 articles (11/2014 - 04/2010)

Related Diseases

1. Neoplasm Metastasis (Metastasis)
2. Ovarian Neoplasms (Ovarian Cancer)
3. T-Cell Lymphoma (Lymphoma, T Cell)
4. Neoplasms (Cancer)
5. Carcinoma (Carcinomatosis)

Related Drugs and Biologics

1. Neural Cell Adhesion Molecule L1 (L1 Cell Adhesion Molecule)
2. Messenger RNA (mRNA)
3. Immunoglobulins (Immunoglobulin)
4. Antibodies
5. beta Catenin
6. Cell Adhesion Molecules
7. Transforming Growth Factors (Transforming Growth Factor)
8. Extracellular Matrix Proteins
9. Digoxin (Digitek)
10. tumor-associated antigen GA733

Related Therapies and Procedures

1. Radioimmunotherapy
2. Heterologous Transplantation (Xenotransplantation)
3. Therapeutics
4. Lasers (Laser)
5. Drug Therapy (Chemotherapy)