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Iridoids

A type of MONOTERPENES, derived from geraniol. They have the general form of cyclopentanopyran, but in some cases, one of the rings is broken as in the case of secoiridoid. They are different from the similarly named iridals (TRITERPENES).
Also Known As:
Iridoid Aglycones; Aglycones, Iridoid; Derivatives, Iridoid; Iridoid; Iridoid Derivatives; Secoiridoids
Networked: 254 relevant articles (21 outcomes, 43 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Li, Lin: 12 articles (01/2021 - 11/2005)
2. Zhang, Lan: 10 articles (01/2021 - 05/2010)
3. Zhang, Li: 9 articles (01/2021 - 11/2005)
4. Kucharska, Alicja Z: 7 articles (03/2022 - 11/2016)
5. Segura-Carretero, Antonio: 7 articles (12/2019 - 10/2008)
6. Sozański, Tomasz: 6 articles (10/2021 - 11/2016)
7. Szeląg, Adam: 6 articles (10/2021 - 11/2016)
8. Oliveras-Ferraros, Cristina: 6 articles (02/2013 - 10/2008)
9. Matuszewska, Agnieszka: 5 articles (10/2021 - 11/2018)
10. Piórecki, Narcyz: 5 articles (10/2021 - 11/2016)

Related Diseases

1. Inflammation (Inflammations)
2. Brain Ischemia (Cerebral Ischemia)
3. Chronic Obstructive Pulmonary Disease (COPD)
4. Neoplasms (Cancer)
5. Body Weight (Weight, Body)
01/01/2020 - "In the present study, we evaluated the protective effect of Fructus Gardeniae iridoid glycoside extracts (IGEs) against IAV by cytopathogenic effect(CPE), MTT and a plaque formation assay in vitro and examined the reduction in the pulmonary index (PI), restoration of body weight, reduction in mortality and increases in survival time in vivo. "
06/01/1989 - "The iridoid content was as high as 2% of the intact body weight, and a large portion was found in the cornicle secretion. "
07/01/2007 - "Based upon these facts, we prepared Corni Fructus fractions and evaluated which fraction contained the effective components against diabetes, using one iridoid glycoside and three polyphenol fractions, which were expected to possess stronger activities than Corni Fructus, administered orally at a dose of 20 mg/kg body weight/d for 10 d, respectively. "
10/01/2015 - "(1) Compared to normal group in both experiments, the diazepam-treated group exhibited obvious withdrawal symptoms of tail-erection, irritability, teeth chattering, etc; the body weight of them after withdrawal had a period of significant loss (P < 0.05 or P < 0.01); and the ratios of tail-erection and seizure in two experiments were improved significantly when mice were induced by mixer noise ringtone (experiment I) or PTZ (experiment II) (P < 0.05 or P < 0.01).(2) In experiment I and II, there were no significant differences between mice that received ethanolic extract or iridoid-rich fraction and normal group in terms of natural withdrawal symptoms and withdrawal-induced body weight change (P > 0.05); in audiogenic tail-erection test, it found that the significant difference compared with normal group was just in ethanolic extract 900 mg/kg dose group on week 8 (P < 0.05); in PTZ-induced convulsion test, mice in iridoid-rich fraction groups had a slightly tail-erection and seizure, all results of them were with no significant difference compare to normal mice (P > 0.05), while significant lower than diazepam group (P < 0.01). "
02/15/2023 - "This study aimed to determine the effect of two different doses (10 mg and 50 mg per kg of body weight, respectively) of iridoid and anthocyanin-rich resin-purified Cornelian cherry extract on the markers that are important in the progress of inflammation, cell proliferation and adhesion, immune system cell infiltration, and atherosclerotic lesion development in a cholesterol-rich diet rabbit model. "

Related Drugs and Biologics

1. Glycosides
2. Flavonoids
3. Alkaloids
4. catalpol
5. geniposide
6. Antioxidants
7. genipin
8. huanglian-jie-du decoction
9. loganin
10. Proteins (Proteins, Gene)

Related Therapies and Procedures

1. Oral Administration
2. Therapeutics
3. Chinese Traditional Medicine (Traditional Chinese Medicine)
4. Chemoprevention
5. Traditional Medicine (Folk Remedies)