Prokaryotic Initiation Factor-3

A prokaryotic initiation factor that plays a role in recycling of ribosomal subunits for a new round of translational initiation. It binds to 16S RIBOSOMAL RNA and stimulates the dissociation of vacant 70S ribosomes. It may also be involved in the preferential binding of initiator tRNA to the 30S initiation complex.

Also Known As:

Initiation Factor IF-3; Peptide Initiation Factor 3; Prokaryotic Peptide Initiation Factor-3; TIF IF3; Translation Initiation Factor 3; IF-3, Initiation Factor; Initiation Factor IF 3; Initiation Factor-3, Prokaryotic; Peptide Initiation Factor IF 3; Prokaryotic Initiation Factor 3; Prokaryotic Peptide Initiation Factor 3; Peptide Initiation Factor IF-3

Networked: 70 relevant articles (0 outcomes, 8 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Ribosomal Proteins: 1138
    - Peptide Initiation Factors: 1364
      - Prokaryotic Initiation Factors
        Prokaryotic Initiation Factor-3: 70
        Myxococcus xanthus Dsg protein

Experts

1.	Liu, Jie: 2 articles (01/2022 - 08/2019)
2.	Zhang, Jian-Ting: 2 articles (01/2022 - 01/2021)
3.	Chen, Juan: 2 articles (01/2021 - 03/2015)
4.	Cai, Xianjun: 2 articles (01/2019 - 01/2018)
5.	Liu, Xishi: 2 articles (01/2019 - 01/2018)
6.	Shen, Minhong: 2 articles (01/2019 - 01/2018)
7.	Jou, Yuh-Shan: 2 articles (03/2018 - 07/2013)
8.	Amako, Yuka: 1 article (12/2022)
9.	Budnik, Bogdan: 1 article (12/2022)
10.	Flaxman, Hope A: 1 article (12/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "Eukaryotic translation initiation factor 3 subunit i (eIF3i) promotes tumor growth by selectively regulating gene translation, but the underlying mechanisms are largely unknown. " 12/01/2022 - "It was reported that eukaryotic translation initiation factor 3 subunit B (EIF3B) is associated with multiple types of cancers, but its role in MM has not been reported. " 01/01/2021 - "Eukaryotic translation initiation factor 3 subunit B (EIF3B) is necessary for tumor growth, which is an alternative therapeutic target for many cancers. " 07/01/2020 - "Eukaryotic translation initiation factor 3 subunit B (EIF3B) is closely linked to the transcription initiation of cancer-associated genes. " 01/01/2019 - "However, METTL3 can also modulate the cancer process by directly promoting the translation of oncogenes via interaction with the translation initiation machinery through recruitment of eukaryotic translation initiation factor 3 subunit h (eIF3h). "
2.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/2020 - "The study aimed to investigate the effect of eukaryotic translation initiation factor 3 subunit B (EIF3B) on cell proliferation, migration, and apoptosis as well as the underlying mechanism in acute myeloid leukemia (AML). " 01/01/2020 - "Knockdown of eukaryotic translation initiation factor 3 subunit B inhibits cell proliferation and migration and promotes apoptosis by downregulating WNT signaling pathway in acute myeloid leukemia." 01/01/2018 - "Knockdown of eukaryotic translation initiation factor 3 subunit D (eIF3D) inhibits proliferation of acute myeloid leukemia cells."
3.	Pancreatic Neoplasms (Pancreatic Cancer) 03/01/2021 - "This study aimed to analyze the relative expression of Eukaryotic Translation Initiation Factor 3 Subunit B (EIF3B) in pancreatic cancer and elucidate its contribution to this disease. " 01/01/2021 - "Eukaryotic Translation Initiation Factor 3 Subunit B Is a Promoter in the Development and Progression of Pancreatic Cancer."
4.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/01/2021 - "Objective: This study was undertaken to investigate eukaryotic translation initiation factor 3 subunit B (EIF3B) expression and its clinical value for indicating disease progression and prognosis in adult Philadelphia chromosome negative acute lymphoblastic leukemia (Ph- ALL) patients. "
5.	Disease Progression 01/01/2021 - "Objective: This study was undertaken to investigate eukaryotic translation initiation factor 3 subunit B (EIF3B) expression and its clinical value for indicating disease progression and prognosis in adult Philadelphia chromosome negative acute lymphoblastic leukemia (Ph- ALL) patients. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	RNA (Ribonucleic Acid)
3.	Messenger RNA (mRNA)
4.	Small Interfering RNA (siRNA)
5.	Nudix Hydrolases
6.	Eukaryotic Initiation Factor-3
7.	Tubulin
8.	Tropomyosin
9.	ErbB Receptors (EGF Receptor)
10.	Septins

Related Therapies and Procedures

1.	Chemoradiotherapy