Integrin beta4

Also known as CD104 antigen, this protein is distinguished from other beta integrins by its relatively long cytoplasmic domain (approximately 1000 amino acids vs. approximately 50). Five alternatively spliced isoforms have been described.

Also Known As:

Networked: 130 relevant articles (1 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ahmed, A R: 5 articles (11/2007 - 02/2001)
2.	Zhao, Jing: 4 articles (04/2010 - 01/2008)
3.	Jones, Jonathan C R: 4 articles (06/2009 - 02/2003)
4.	Miao, Junying: 3 articles (04/2010 - 01/2008)
5.	Zhang, Shangli: 3 articles (04/2010 - 01/2008)
6.	Diaz, Leslie K: 3 articles (09/2005 - 02/2004)
7.	Gilcrease, Michael Z: 3 articles (09/2005 - 02/2004)
8.	Zhou, Xiao: 3 articles (09/2005 - 02/2004)
9.	Liu, Chi: 2 articles (08/2010 - 06/2010)
10.	Xiang, Yang: 2 articles (08/2010 - 06/2010)

Related Diseases

1.	Epidermolysis bullosa with pyloric atresia 10/01/1999 - "In a patient who improved from severe to mild PA-JEB, a search for mutations in the integrin beta4 gene (IGTB4) detected heterozygosity for a novel base substitution 3986-19T-->A in the putative branchpoint sequence of intron 31, and a point mutation 3802+1G-->A in the donor splice site of intron 30 previously associated with severe PA-JEB. " 10/01/2003 - "In this study we examined two unrelated patients affected with the lethal variant of junctional epidermolysis bullosa with pyloric atresia (PA-JEB) who were found to carry mutations in the integrin beta4 subunit gene (ITGB4). " 09/01/2020 - "Compound Heterozygous Mutations with a Novel Variant in Integrin Beta4 Cause Epidermolysis Bullosa with Pyloric Atresia and Urologic Abnormalities." 10/01/2004 - "These findings provide new insight into the pathogenic effects of mutations affecting different functional domains of the beta4 integrin molecule and their prognostic implications in PA-JEB patients." 04/01/1998 - "Compound heterozygosity for missense (L156P) and nonsense (R554X) mutations in the beta4 integrin gene (ITGB4) underlies mild, nonlethal phenotype of epidermolysis bullosa with pyloric atresia."
2.	Neoplasms (Cancer) 08/01/2006 - "A study by Guo et al. published recently in Cell indicates that the signaling function of beta4 integrin actively contributes to the initiation, growth, and invasion of ErbB2-induced mammary tumors in transgenic mice by promoting the activation of c-Jun and STAT3. " 10/17/2023 - "Integrin beta 4 (ITGB4) is a vital factor for numerous cancers. " 01/01/2021 - "A Pan-Cancer Analysis of the Oncogenic Role of Integrin Beta4 (ITGB4) in Human Tumors." 01/01/2020 - "Integrin beta 4 (ITGB4) overexpression in cancer cells contributes to cancer progression. " 01/01/2016 - "Integrin beta4 (ITGB4, also known as CD104) is associated with progression of many human cancers. "
3.	Bullous Pemphigoid (Pemphigoid) 09/01/2007 - "The binding of BP180 with either integrin alpha6, integrin beta4, or bullous pemphigoid antigen-1 (BPAG1/BP230) is critical for this attachment in skin. " 03/24/1997 - "The localization of bullous pemphigoid antigen 180 (BP180) in hemidesmosomes is mediated by its cytoplasmic domain and seems to be regulated by the beta4 integrin subunit." 11/01/2007 - "Relative risk for cancer in mucous membrane pemphigoid associated with antibodies to the beta4 integrin subunit." 12/01/2001 - "Cicatricial pemphigoid with circulating autoantibodies to beta4 integrin, bullous pemphigoid 180 and bullous pemphigoid 230." 07/01/2006 - "Previous studies have shown that sera of patients with MMP bind to human integrin beta4, while sera of patients with oral pemphigoid bind to the integrin alpha6 component of the heterodimer. "
4.	Neoplasm Metastasis (Metastasis) 10/01/2009 - "In this study, we showed that expression of the beta4 integrin in MDA-MB-435 cancer cells (MDA-MB-435/beta4) leads to a dramatic increase in expression of a metastasis-promoting factor, S100A4, as determined by affymetrix gene chip microarray, quantitative real-time PCR, and Western blot analysis. " 01/15/2008 - "These data support the inhibitory effect of apigenin on HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and integrin beta 4 function." 09/01/2004 - "Furthermore, loss of adhesion expressed by low E-cadherin and integrin beta4 correlated with the presence of nodal metastases at the time of diagnosis." 09/24/2009 - "These data begin to integrate ezrin and beta4 integrin expression into a model of action for the mechanism of osteosarcoma metastases." 09/24/2009 - "Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin."
5.	Benign Mucous Membrane Pemphigoid (Cicatricial Pemphigoid) 02/01/2001 - "Identification of ocular cicatricial pemphigoid antibody binding site(s) in human beta4 integrin." 09/01/1999 - "The role of antibody to human beta4 integrin in conjunctival basement membrane separation: possible in vitro model for ocular cicatricial pemphigoid." 09/01/1999 - "To demonstrate the specific binding of autoantibodies present in the sera of patients with ocular cicatricial pemphigoid (OCP) to human beta4 integrin present in the normal human conjunctiva (NHC) and to study the role of OCP autoantibodies and antibody to human beta4 integrin in the pathogenesis of subepithelial lesion formation in OCP. " 12/01/2001 - "Cicatricial pemphigoid with circulating autoantibodies to beta4 integrin, bullous pemphigoid 180 and bullous pemphigoid 230." 11/01/2007 - "The incidence of cancer was studied in 79 patients with MMP and/or ocular cicatricial pemphigoid (OCP) who had antibodies to human beta4 integrin subunit. "

Related Drugs and Biologics

1.	Matrix Metalloproteinases (MMPs)
2.	Integrin alpha6
3.	Autoantibodies
4.	Small Interfering RNA (siRNA)
5.	Antibodies
6.	Monoclonal Antibodies
7.	Cadherins (E-Cadherin)
8.	matrigel
9.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)
10.	Acridine Orange

Related Therapies and Procedures

1.	Therapeutics
2.	Prostatectomy (Retropubic Prostatectomy)
3.	Lasers (Laser)
4.	Gingivectomy