Eukaryotic Initiation Factors

Peptide initiation factors from eukaryotic organisms. Over twelve factors are involved in PEPTIDE CHAIN INITIATION, TRANSLATIONAL in eukaryotic cells. Many of these factors play a role in controlling the rate of MRNA TRANSLATION.

Also Known As:

Networked: 22 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Benesch, Martin: 2 articles (03/2021 - 01/2021)
2.	Birkl-Toeglhofer, Anna Maria: 2 articles (03/2021 - 01/2021)
3.	Haybaeck, Johannes: 2 articles (03/2021 - 01/2021)
4.	Krassnig, Stefanie: 2 articles (03/2021 - 01/2021)
5.	Raicht, Andrea: 2 articles (03/2021 - 01/2021)
6.	Skofler, Christina: 2 articles (03/2021 - 01/2021)
7.	Garland, Gavin D: 1 article (11/2022)
8.	Harvey, Robert F: 1 article (11/2022)
9.	Rubio, Angela: 1 article (11/2022)
10.	Sfakianos, Aristeidis: 1 article (11/2022)

Related Diseases

1.	Ischemia 02/01/2002 - "Protein synthesis inhibition occurs in neurons immediately on reperfusion after ischemia and involves at least alterations in eukaryotic initiation factors 2 (eIF2) and 4 (eIF4). " 07/01/2006 - "Biochemical study further suggested that translational complex components, including small ribosomal subunit protein 6 (S6), large subunit protein 28 (L28), eukaryotic initiation factors 2alpha, 4E and 3eta, and co-translational chaperone heat-shock cognate protein 70 (HSC70) and co-chaperone Hdj1, were all irreversibly clumped into large abnormal protein aggregates after ischemia. "
2.	Diabetes Complications 02/01/2003 - "Characterization of mice rendered deficient in eukaryotic initiation factors has provided model systems to study the involvement of translation in regulating insulin synthesis and secretion, hepatic function, peripheral insulin resistance, and diabetic complications. "
3.	Insulin Resistance 02/01/2003 - "Characterization of mice rendered deficient in eukaryotic initiation factors has provided model systems to study the involvement of translation in regulating insulin synthesis and secretion, hepatic function, peripheral insulin resistance, and diabetic complications. "
4.	Hepatocellular Carcinoma (Hepatoma) 07/01/2000 - "In this study, using primary human hepatocellular carcinoma (HCC) tissues, we examined gene expression of translation factors, including 2 eukaryotic initiation factors (eIFs-4A1, -4E), 4 elongation factors (eEFs-1 alpha, -1 gamma, -1 delta, and -2) and 10 ribosomal proteins (Rps P1, P2, S10, L35, L5, L39, L9, L6, S3a and S17), whose mRNA expression has never been examined in HCC. "
5.	Neoplasms (Cancer) 11/01/2022 - "It is therefore unsurprising that abnormal expression levels and activities of eukaryotic initiation factors (eIFs), elongation factors (eEFs) or termination factors (eRFs) are associated with poor outcome for patients with a wide range of cancers. " 01/01/2021 - "Malignant tumor development has been shown to be driven by the dysregulation of eukaryotic initiation factors (eIFs) at the translation initiation. " 01/01/2016 - "Role of Eukaryotic Initiation Factors during Cellular Stress and Cancer Progression." 10/01/2023 - "Eukaryotic initiation factors (eIFs) are altered in various cancer entities, including gliomas. " 08/22/2017 - "Among the eukaryotic initiation factors that govern the translational machinery, 4E-BP1 represents a master regulator of protein synthesis that is associated with the development and progression of cancers due to its ability to increase protein expression of oncogenic pathways. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Insulin (Novolin)
3.	Protein Aggregates
4.	Protein Subunits (Protein Subunit)
5.	Messenger RNA (mRNA)
6.	Ribosomal Proteins (Ribosomal Protein)
7.	L 35 (L35)
8.	Eukaryotic Initiation Factor-2 (EIF 2)
9.	R-SNARE Proteins (Vesicle-Associated Membrane Protein)
10.	RNA Helicases (RNA Helicase)

Related Therapies and Procedures

1.	Therapeutics
2.	Resuscitation