Integrin beta Chains

Integrin beta chains combine with integrin alpha chains to form heterodimeric cell surface receptors. Integrins have traditionally been classified into functional groups based on the identity of one of three beta chains present in the heterodimer. The beta chain is necessary and sufficient for integrin-dependent signaling. Its short cytoplasmic tail contains sequences critical for inside-out signaling.

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Networked: 15 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Celiksoy, Mehmet Halil: 1 article (10/2021)
2.	Gezdirici, Alper: 1 article (10/2021)
3.	Gungor, Songul: 1 article (10/2021)
4.	Köker, Mustafa Yavuz: 1 article (10/2021)
5.	Malbora, Baris: 1 article (10/2021)
6.	Ozsoy, Sevil: 1 article (10/2021)
7.	Chung, Joo-Ho: 1 article (06/2013)
8.	Eun, Young Gyu: 1 article (06/2013)
9.	Kim, Su Kang: 1 article (06/2013)
10.	Kwon, Kee Hwan: 1 article (06/2013)

Related Diseases

1.	Myocardial Infarction 02/25/2003 - "This study aimed to elucidate the role of the beta-integrins in cardiac remodeling after myocardial infarction (MI). "
2.	Papillary Thyroid Cancer 06/01/2013 - "Association study of integrins beta 1 and beta 2 gene polymorphism and papillary thyroid cancer."
3.	Neoplasms (Cancer) 04/15/2012 - "This allows viral entry through alpha-v-beta integrins frequently highly expressed in advanced tumors. " 08/01/2008 - "Analysis of the tumor cell line obtained from this patient demonstrated intact expression of alpha and beta integrins but poor production of vascular endothelial growth factor, and also the ability to inhibit solid tumor formation of third-party melanoma tumors, suggesting a strong antiangiogenic activity. " 08/01/1997 - "Thalidomide may impede cell migration in primates by down-regulating integrin beta-chains: potential therapeutic utility in solid malignancies, proliferative retinopathy, inflammatory disorders, neointimal hyperplasia, and osteoporosis."
4.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 08/01/2009 - "We used two variants of a mouse acute lymphocytic leukemia cell line (L1210), a suspension (L1210-S) and an adherent (L1210-A) variant that were characterized by nonactivated and activated integrins (beta(1), beta(2) and beta(3)), respectively. "
5.	Myocardial Ischemia (Ischemic Heart Diseases) 06/01/2004 - "Neutrophil beta-integrins (CD11b/CD18), tumor necrosis factor alpha (TNF-alpha), and interleukin (IL)-6 were measured as indicators of the inflammatory response to myocardial ischemia-reperfusion injury. "

Related Drugs and Biologics

1.	Integrins
2.	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
3.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
4.	Coxsackie and Adenovirus Receptor-Like Membrane Protein
5.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
6.	Semaphorins (Semaphorin)
7.	Selectins
8.	E-Selectin
9.	Cadherins (E-Cadherin)
10.	Cell Adhesion Molecules