|1.||Hershey, John W B: 4 articles (07/2015 - 06/2003)|
|2.||Leibovitch, Serge A: 4 articles (01/2015 - 04/2008)|
|3.||Zhang, Jian-Ting: 3 articles (06/2013 - 05/2004)|
|4.||Shi, Jiaqi: 3 articles (01/2012 - 03/2008)|
|5.||Csibi, Alfredo: 3 articles (02/2009 - 04/2008)|
|6.||Tintignac, Lionel A: 3 articles (02/2009 - 04/2008)|
|7.||Cate, Jamie H D: 2 articles (06/2015 - 12/2011)|
|8.||Leibovitch, Marie P: 2 articles (01/2015 - 04/2008)|
|9.||Obrist, Peter: 2 articles (08/2014 - 08/2004)|
|10.||Bachmann, Felix: 2 articles (08/2014 - 08/2004)|
07/01/2015 - "EIF3 is the largest multi-protein complex, and several studies have revealed the oncogenic roles of its subunits in many human cancers. "
09/15/2015 - "We further show that two, yet uncharacterized, cancer-associated mutations in the eIF3-complex, have the capacity to recover from reduced size phenotype, suggesting a possible role for eIF3 in regulating cancer cell size. "
07/01/2015 - "The involvement of eIF3 in cancer reinforces the view that translational control plays an important role in the regulation of cell proliferation, and provides new targets for the development of therapeutic agents. "
07/01/2015 - "Methods employed to detect altered levels of eIF3 subunits in cancers are critically evaluated in order to conclude rigorously that such subunits may cause malignant transformation. "
07/01/2015 - "Specific individual subunits of eIF3 are elevated or reduced in numerous human tumors, and their ectopic overexpression in immortal cells can result in malignant transformation. "
09/01/1984 - "We have developed a series of in vitro protein synthesis assays to show that eIF3 is active but a CBP complex activity is inactivated after poliovirus infection. "
04/01/1982 - "The results suggest that the association of the CBP with eIF-3 into a functional complex may have been disrupted during the course of poliovirus infection."
07/01/2015 - "New possible targets for antiviral strategies have also been identified following the characterization of other plant translation factors (eIF4A-like helicases, eIF3, eEF1A and eEF1B) that specifically interact with viral RNAs and proteins and regulate various aspects of the infection cycle. "
04/01/2010 - "It has been shown previously that in mammalian cells, interferon-induced protein with tetratricopeptide repeats-1(IFIT1) is rapidly synthesized in response to viral infection, functions as an inhibitor of translation by binding to the eukaryotic initiation factor-3, and consequently assigns resistive activity against viral invasion to cells. "
08/15/2004 - "Modulation of the affinity of eIF3 to bind to HCV mRNA may be a promising target for the treatment of chronic HCV infection."
|3.||Lung Neoplasms (Lung Cancer)
05/06/2004 - "P170, the largest putative subunit of eIF3, has been found elevated in human breast, cervical, esophageal, and lung cancers, suggesting that p170 may have a potential role in malignant transformation and/or cell growth control. "
08/01/2010 - "To explore the dose-dependent and time-dependent effect of docetaxel on the expression of mammalian eukaryotic initiation factor 3 subunit A (eIF3a) in lung cancer cell line. "
06/01/2001 - "We previously identified a 170-kDa protein (p170) highly expressed in lung cancers as the major subunit of the eukaryotic translation initiation factor 3 (eIF3). "
06/01/2001 - "In this paper, we report our findings that a 170-kDa protein (p170) is over-expressed in all types of human lung cancers compared with normal tissues and it is identified as a subunit of translation initiation factor eIF3 by cDNA cloning. "
|4.||Muscular Atrophy (Muscle Atrophy)
06/15/2008 - "We have recently presented evidence that eIF3-f, a regulatory subunit of the eukaryotic translation factor eIF3 is a key target that accounts for MAFbx/Atrogin-1 function in muscle atrophy. "
02/13/2009 - "We recently presented evidence that the subunit eIF3-f of the eukaryotic initiation translation factor eIF3 that interacts with the E3-ligase Atrogin-1/muscle atrophy F-box (MAFbx) for polyubiquitination and proteasome-mediated degradation is a key target that accounts for MAFbx function during muscle atrophy. "
04/23/2008 - "Here, we present evidence that during muscle atrophy MAFbx targets the eukaryotic initiation factor 3 subunit 5 (eIF3-f) for ubiquitination and degradation by the proteasome. "
06/15/2009 - "We conclude that under specific stress conditions, such as robust heat shock, yeast SGs do contain eIF3 and 40S ribosomes and utilize alternative routes for their assembly."
06/15/2009 - "We have analyzed the effect of robust heat shock on distribution of eIF3a/Tif32p/Rpg1p and showed that it results in the formation of eIF3a accumulations containing other eIF3 subunits, known yeast SG components and small but not large ribosomal subunits and eIF2alpha/Sui2p. "
06/15/2009 - "Robust heat shock induces eIF2alpha-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae."
01/01/2013 - "The VSV-induced granules appear to be similar to the stress granules (SGs) generated in cells triggered by heat shock or oxidative stress but do not contain some of the bona fide SG markers, such as eukaryotic initiation factor 3 (eIF3) or eIF4A, or the processing body (PB) markers, such as mRNA-decapping enzyme 1A (DCP1a), and thus may not represent canonical SGs or PBs. "
|1.||Proteins (Proteins, Gene)
|4.||Peptide Initiation Factors (Initiation Factor)
|5.||Messenger RNA (mRNA)
|6.||Prokaryotic Initiation Factor-3
|7.||Eukaryotic Initiation Factor-3
|8.||Proteasome Endopeptidase Complex (Proteasome)
|9.||Staphylococcal Protein A (A, Protein)
|10.||RNA (Ribonucleic Acid)