|1.||Chen, Xiaoyuan: 10 articles (05/2008 - 01/2004)|
|2.||Park, Ryan: 6 articles (01/2006 - 01/2004)|
|3.||Conti, Peter S: 6 articles (01/2006 - 01/2004)|
|4.||Tohme, Michel: 6 articles (01/2006 - 01/2004)|
|5.||Bading, James R: 6 articles (01/2006 - 01/2004)|
|6.||Sheppard, Dean: 5 articles (01/2008 - 01/2002)|
|7.||Hou, Yingping: 5 articles (03/2005 - 08/2004)|
|8.||McCarty, Joseph H: 4 articles (07/2011 - 11/2002)|
|9.||Carreiras, Franck: 4 articles (05/2010 - 01/2002)|
|10.||Nemeth, Jeffrey A: 4 articles (06/2008 - 06/2004)|
09/01/2004 - "Overall, 64Cu-DOTA-E[c(RGDyK)]2 yielded better position emission tomography (PET) images in orthotopic MDA-MB-435 bearing mice than did 64Cu-DOTA-E[c(RGDfK)]2. Both radiotracers had alphav-integrin specific tumor activity accumulation, as demonstrated by significant reduction of uptake with a coinjected blocking dose of c(RGDyK). "
07/01/2011 - "Alpha v integrin was expressed at robust levels in tumor cells representing less differentiated, more invasive components of SCC; by contrast, well-differentiated cells as well as SCC in situ expressed low levels of αv integrin protein."
01/01/2010 - "New RGD cyclopeptides were selected on the basis of their high affinity to alpha(v) integrin receptors overexpressed by tumor cells and their metabolic stability. "
04/01/2009 - "Binding of OPN to its cell membrane receptors integrin alphav and CD44v6 can enhance tumor cell motility, migration, invasion and spread. "
10/01/2007 - "Moreover, in cancer samples that expressed the HOXD11 gene, the expression of alphaV integrin was lower with respect to normal mucosas. "
|2.||Breast Neoplasms (Breast Cancer)
02/01/2000 - "The aim of this study was to show the anti-adhesive potential of an antisense oligodeoxynucleotide (ODN) approach when designed to suppress the cellular function of the alphaV integrin subunit in breast cancer cells. "
01/01/2005 - "Integrin alpha(v)beta3 expression appears to play a key role in the development of BM from breast cancer."
01/01/2005 - "We studied BM from breast cancer in relation to its Integrin alpha(v)beta3 expression. "
01/01/2005 - "Integrin alpha(v)beta3 mediates the attachment of osteoclasts to bone matrix, and it is overexpressed in bone-residing breast cancer cells. "
02/01/2000 - "An antisense oligonucleotide targeting the alphaV integrin gene inhibits adhesion and induces apoptosis in breast cancer cells."
|3.||Neoplasm Metastasis (Metastasis)
01/01/2009 - "The integrin alpha(v)beta3 is overexpressed during tumour spread and metastasis and therefore is an attractive target for monitoring angiogenetic processes. "
09/15/2008 - "They also identify alphaV integrin inhibition as a potential therapeutic approach for preventing metastasis in patients at risk for postradiation recurrences."
11/01/2005 - "bFGF and alphaV integrin expression in effusions was also altered compared to lymph node metastases (p = 0.041 and p = 0.016, respectively). "
01/01/2002 - "To clarify the function of integrin alpha(v)beta3 in the early stage of liver metastasis, we investigated the interactions of metastatic cells with their target organ under the actual blood flow by using positron emission tomography (PET). "
01/01/2002 - "Role of integrin alpha(v)beta3 in the early phase of liver metastasis: PET and IVM analyses."
|4.||Melanoma (Melanoma, Malignant)
04/15/1997 - "Therefore, in the present study, we have analyzed the distribution in lesions of melanocyte origin and in normal tissues of the alpha(v) integrin subunit and of the alpha(v)beta3 complex and their association with histopathological and clinical parameters of malignant melanoma. "
06/01/2006 - "(3) We inserted an RGD sequence into the fiber to extend viral tropism to alphav integrin-expressing cells, and (4) swapped the fiber with the Ad35 fiber (F35) enhancing the tropism to malignant melanoma cells expressing CD46. "
01/01/2006 - "alphav-integrin was seen mostly in aggressive melanomas. "
11/22/2004 - "This suggests that integrin alphav controls melanoma cell survival in 3D-collagen through a pathway involving p53 regulation of MEK1 signaling."
11/22/2004 - "Surprisingly, MEK1 and ERK1/2 activities were restored in integrin alphav-negative melanoma cells by suppression of p53, whereas concomitant block of MEK1 induced apoptosis. "
04/01/2005 - "The aim of this study was to analyze the expression of ADAM15 and its potential ligand, integrin alpha(v)beta3 (CD51/CD61), in lung carcinoma cell lines and tissues. "
11/01/2004 - "The high expressions of integrin alphav and beta5 in ovarian epithelial carcinoma are risk factors for drug resistance and poor disease prognosis."
11/01/2004 - "According to multivariate analysis, the expression of integrin alphav and beta5 and clinical stage were three independent factors correlated with drug resistance and disease prognosis for the patients with ovarian epithelial carcinoma (P = 0.014, 0.030, 0.042 for drug resistance; and P = 0.045, 0.031, 0.001 for prognosis respectively). "
08/01/2003 - "The alphav- and beta1-integrin subunits are frequently expressed in ovarian carcinoma cells in effusions, and the alphav-integrin subunit is a powerful diagnostic marker for carcinoma cells. "
12/01/2001 - "Alphav integrin is, thus, a novel prognostic marker in advanced-stage ovarian carcinoma."
|3.||Small Interfering RNA (siRNA)
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Drug Therapy (Chemotherapy)
|5.||Coronary Balloon Angioplasty (Percutaneous Transluminal Coronary Angioplasty)