Non-Sedating Histamine H1 Antagonists (Histamine H1 Antagonists, Non Sedating)

A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.

Also Known As:

Networked: 215 relevant articles (42 outcomes, 32 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Maurer, Marcus: 5 articles (01/2019 - 10/2008)
2.	Godse, Kiran: 3 articles (11/2021 - 11/2015)
3.	Baum, Sharon: 3 articles (11/2020 - 05/2011)
4.	Tashiro, Manabu: 3 articles (02/2015 - 08/2004)
5.	Yanai, Kazuhiko: 3 articles (02/2015 - 08/2004)
6.	Kaliner, Michael A: 3 articles (11/2009 - 04/2005)
7.	Berger, William E: 3 articles (01/2005 - 01/2003)
8.	Chen, Xiang: 2 articles (03/2022 - 07/2017)
9.	Li, Jie: 2 articles (03/2022 - 07/2017)
10.	Patil, Anant D: 2 articles (11/2021 - 11/2020)

Related Diseases

1.	Allergic Rhinitis 01/01/2000 - "Overall, therefore, the data indicate that FPANS is superior to second-generation antihistamines in the management of allergic rhinitis." 03/01/2005 - "This is despite the fact that the second-generation antihistamines are largely free of the undesirable side effects associated with their predecessors and the fact that they have been shown to be effective in relieving allergic rhinitis symptoms in children in a number of large-scale clinical trials. " 07/01/1993 - "The purpose of the study was to evaluate the efficacy of both as second generation antihistamines used in the treatment of allergic rhinitis. " 01/01/2014 - "Reasons for prescribing second generation antihistamines to treat allergic rhinitis in real-life conditions and patient response." 06/01/2009 - "Costs of second-generation antihistamines in the treatment of allergic rhinitis: US perspective."
2.	Urticaria (Hives) 01/01/2022 - "The second-generation antihistamines at licensed doses are first-line treatment in urticaria and up-dosing is recommended as second-line treatment. " 01/01/2018 - "Physicians who follow a urticaria guideline showed higher rates of using second generation antihistamines as their first-line treatment of CSU (p = 0.001) and more frequently observed higher efficacy of these drugs (or had more confidence that it would work, p < 0.019) as compared to those who do not follow the guidelines. " 10/01/2011 - "Nonsedative, second-generation antihistamines are recommended as first-line treatment for urticaria. " 01/01/2001 - "A review of the literature reveals that there are few studies which document the efficacy of second-generation antihistamines in the treatment of acute urticaria, a biologic entity that usually resolves within 3 weeks. " 01/01/2013 - "More studies with other second-generation antihistamines are required in order to improve the treatment of patients with severe, recalcitrant urticaria."
3.	Chronic Urticaria 02/01/2014 - "Second-generation antihistamines are unquestionably the first-line treatment for chronic urticaria and can be used at higher than licensed doses if normal doses fail to control the disease. " 03/01/2023 - "Oral second-generation antihistamines (sgAH) constitute the first-line treatment for chronic spontaneous urticaria (CSU), a debilitating dermatological condition. " 12/01/2011 - "There was a universal agreement among the articles reviewed, that low-sedating, second-generation antihistamines should be prescribed as a first-line treatment of chronic urticaria. " 08/19/2023 - "Non-sedating H1 -antihistamines (nsAH) are the most commonly used treatment for chronic spontaneous urticaria (CSU). " 03/01/2023 - "Efficacy and Safety of Up-dosed Second-generation Antihistamines in Uncontrolled Chronic Spontaneous Urticaria: A Review."
4.	Seasonal Allergic Rhinitis (Hay Fever) 05/01/2006 - "The aim of this study is to assess the clinical efficacy and cost-quality of 7 major second-generation antihistamines in early treatment for Japanese cedar pollinosis (JCP). " 12/01/2001 - "Second generation antihistamines have been employed in the treatment of seasonal allergic rhinitis for many years. " 12/01/2001 - "Second generation antihistamines in the treatment of seasonal allergic rhinitis due to Parietaria and cypress pollen." 01/01/2009 - "It is well known that starting treatment for cedar pollinosis therapy with second-generation antihistamines before the initial day of pollen scattering can relieve nasal symptom severity during the pollen season. " 01/01/1996 - "The efficacy of the second generation antihistamine ebastine has been investigated in the treatment and prevention of seasonal allergic rhinitis (SAR). "
5.	Hypersensitivity (Allergy) 01/01/2005 - "Due to their minimal adverse effects and efficient symptom reduction oral second generation antihistamines are particularly useful for the treatment of less severe intermittent forms of nasal allergy." 08/01/2004 - "Currently available oral second-generation antihistamines do not provide adequate symptom relief for many allergy patients. " 01/01/2005 - "Oral second generation antihistamines are readily absorbed and reduce allergy symptoms for approximately 24 hours, allowing convenient once daily medication. " 07/01/2003 - "PAR patients were found to have higher mean levels of allergy-related outpatient payments (US dollars 568 vs. US dollars 471) and higher mean costs for second-generation antihistamines (US dollars 552 vs. US dollars 162). " 01/01/2001 - "Second generation antihistamines are recognised as being highly effective treatments for allergy-based disease and are among the most frequently prescribed and safest drugs in the world. "

Related Drugs and Biologics

1.	Histamine Antagonists (Antihistamines)
2.	ebastine (Kestin)
3.	Loratadine (Alavert)
4.	mizolastine (Zolim)
5.	Cetirizine (Zyrtec)
6.	fexofenadine (Allegra)
7.	montelukast (Singulair)
8.	Adrenal Cortex Hormones (Corticosteroids)
9.	Histamine (Histamine Dihydrochloride)
10.	Astemizole

Related Therapies and Procedures

1.	Therapeutics
2.	Off-Label Use
3.	Drug Therapy (Chemotherapy)
4.	Tobacco Use Cessation Devices
5.	Condoms (Condom)