Eukaryotic Initiation Factor-4F (EIF4F)

A trimeric peptide initiation factor complex that associates with the 5' MRNA cap structure of RNA (RNA CAPS) and plays an essential role in MRNA TRANSLATION. It is composed of EUKARYOTIC INITIATION FACTOR-4A; EUKARYOTIC INITIATION FACTOR-4E; and EUKARYOTIC INITIATION FACTOR-4G.

Also Known As:

EIF4F; EIF-(iso)4F; EIF4F Translation Initiation Complex; Eukaryotic Initiation Factor-(iso)4F; Protein Initiation Factor EIF-4F; EIF 4F; Eukaryotic Initiation Factor 4F; Initiation Factor-4F, Eukaryotic; Peptide Initiation Factor EIF 4F; Protein Initiation Factor EIF 4F; EIF-4F; Peptide Initiation Factor EIF-4F

Networked: 149 relevant articles (3 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nucleoproteins: 1870
    - RNA-Binding Proteins: 3262
      - RNA Cap-Binding Proteins: 60
        Eukaryotic Initiation Factor-4F: 149
        S cerevisiae TIF1 protein
        S cerevisiae TIF2 protein
        S cerevisiae TIF4632 protein
  - Ribosomal Proteins: 1138
    - Peptide Initiation Factors: 1364
      - Eukaryotic Initiation Factors: 22
        Eukaryotic Initiation Factor-4F: 149
        Eukaryotic Initiation Factor-4E: 979
        Eukaryotic Initiation Factor-4G: 165
        Eukaryotic Initiation Factor-4A: 32
        S cerevisiae TIF1 protein
        S cerevisiae TIF2 protein
        S cerevisiae TIF4632 protein

Experts

1.	Pelletier, Jerry: 12 articles (01/2020 - 10/2009)
2.	Vagner, Stéphan: 7 articles (02/2022 - 06/2011)
3.	Bitterman, Peter B: 7 articles (01/2019 - 06/2004)
4.	Sonenberg, Nahum: 7 articles (12/2018 - 06/2004)
5.	Kratzke, Robert A: 6 articles (01/2020 - 03/2011)
6.	Patel, Manish R: 6 articles (01/2020 - 03/2011)
7.	Polunovsky, Vitaly A: 6 articles (01/2017 - 06/2004)
8.	Robert, Caroline: 5 articles (02/2022 - 09/2014)
9.	Jacobson, Blake A: 5 articles (01/2020 - 01/2013)
10.	Walsh, Derek: 5 articles (01/2011 - 03/2004)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "Using both genetic and pharmacologic methods, we demonstrate that dissociation of the eIF4F complex reverses the proliferation program, resulting in decreased tumor growth and improved survival in preclinical models. " 01/01/2019 - "Although eIF4F is important in cancer and for brain function, there is not always a clear path to use the results of studies performed in cancer models to inform one of the roles that the same translation factors have in neuronal signaling. " 08/11/2023 - "These findings have significant implications for evaluating cancer cell vulnerability to eIF4F inhibition and developing treatments that target cancer cells with dependency on the translation initiation mechanism." 08/11/2023 - "Translation initiation is primarily governed by eIF4F, employing a "cap-dependent" mechanism, but eIF4F dysregulation may lead to a "cap-independent" mechanism in stressed cancer cells. " 08/11/2023 - "Computational inference of eIF4F complex function and structure in human cancers."
2.	Melanoma (Melanoma, Malignant) 01/01/2023 - "This suggests that different tumorigenic contexts differentially regulate the subcellular localization of mRNA translation, with specific localization of eIF4F potentially associated with melanoma cell chemoresistance." 01/01/2023 - "In contrast, the spatial patterns of eIF4F complexes at the single cell level could distinguish melanoma cells harboring different oncogenic driver mutations. " 01/01/2023 - "By using an image-based spot feature analysis pipeline as well as supervised machine learning, we identify five distinct spatial patterns of the eIF4F translation initiation complex in human melanoma cells. " 01/01/2023 - "Spatial patterns of the cap-binding complex eIF4F in human melanoma cells." 02/01/2016 - "We further showed that suppression of the eIF4F complex assembly profoundly inhibited the promoting effect of Cul1 on melanoma cell proliferation, while enhancement of the eIF4F complex activity reversed the inhibitory effect of Cul1 depletion on melanoma cell proliferation, indicating that Cul1 contributes to melanoma cell proliferation by activating cap‑dependent translation. "
3.	Infections 02/01/2014 - "In this study, we found that decreasing the abundance or activity of eIF4F from the start of infection inhibits HCMV replication. " 02/01/2014 - "However, during the late stage of infection the translation efficiency of viral mRNAs does not correlate with the abundance or activity of the host eIF4F complex. " 02/01/2014 - "Together, our data show that the translation of host eIF4F-dependent mRNAs remains dependent on eIF4F activity during HCMV infection. " 02/01/2014 - "A global analysis of the translation efficiency of HCMV mRNAs during the late stage of infection found that eIF4F disruption had a minimal impact on the association of HCMV mRNAs with polysomes but significantly diminished the translation efficiency of eIF4F-dependent host transcripts. " 02/01/2014 - "In contrast, eIF4F inhibition decreased the translation of representative host eIF4F-dependent mRNAs during the late stage of infection. "
4.	Mesothelioma 01/01/2018 - "These data indicate that inhibition of the eIF4F complex by 4EGI-1 or similar translation inhibitors could be a strategy for treating mesothelioma. " 08/01/2014 - "In this study, disrupting the eIF4F complex by antagonizing the eIF4E-mRNA-cap interaction is assessed as a therapy for mesothelioma. " 01/01/2013 - "4EASO is a novel drug that causes apoptosis and selectively reduces eIF4E levels, eIF4F complex formation, and proliferation of mesothelioma cells. " 08/04/2009 - "Activated 4E-BP1 represses tumourigenesis and IGF-I-mediated activation of the eIF4F complex in mesothelioma." 08/01/2014 - "Mesothelioma cells were treated with 4Ei-1, a membrane permeable prodrug that when converted to the active drug, 7-benzyl guanosine monophosphate (7Bn-GMP) displaces capped mRNAs from the eIF4F complex. "
5.	Lymphoma (Lymphomas) 04/19/2012 - "We find elevated Myc levels are associated with deregulated eIF4F activity in the prelymphomatous stage of the Eμ-Myc lymphoma model. " 03/01/2011 - "Expression of components of the eIF-4F complex and unphosphorylated and phosphorylated 4E-BP1 was confirmed using Western immunoblotting on lysates of frozen lymphoma samples and reactive tissues. " 04/20/2015 - "These studies demonstrate that the eIF4F complex is deregulated in aggressive lymphoma and that dual mTOR therapy has therapeutic potential in these patients." 06/14/2011 - "Myc-driven lymphomas contain PKCβII and phosphorylated eIF6; eIF6 is phosphorylated by tumor-derived PKCβII, but not by the eIF4F activator mTORC1. " 01/01/2021 - "Targeting eIF4F translation initiation complex with SBI-756 sensitises B lymphoma cells to venetoclax."

Related Drugs and Biologics

1.	Eukaryotic Initiation Factor-4F (EIF4F)
2.	Eukaryotic Initiation Factor-4E
3.	Proteins (Proteins, Gene)
4.	Eukaryotic Initiation Factor-4G (Eukaryotic Initiation Factor 4G)
5.	salubrinal
6.	4- ((3Z)- 3- ((5- (4- nitrophenyl)furan- 2- yl)methylidene)- 2- oxo- 5- phenylpyrrol- 1- yl)benzoic acid
7.	Peptide Initiation Factors (Initiation Factor)
8.	RNA Cap-Binding Proteins (Cap Binding Protein)
9.	Phosphotransferases (Kinase)
10.	Proteome

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Radiotherapy
4.	Drug Therapy (Chemotherapy)